sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3chr | 4BS | Leukotriene A-4 hydrolase | 3.3.2.6 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3chr | 4BS | Leukotriene A-4 hydrolase | 3.3.2.6 | 1.000 | |
| 3fui | 812 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.575 | |
| 3cho | 4BG | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.515 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.514 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.510 | |
| 2r6h | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.505 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.502 | |
| 1exa | 394 | Retinoic acid receptor gamma | / | 0.501 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.496 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.488 | |
| 3qp6 | HL6 | Transcriptional activator, LuxR/UhpA family of regulators | / | 0.487 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 2pnu | ENM | Androgen receptor | / | 0.485 | |
| 1xp6 | AIU | Estrogen receptor | / | 0.484 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.483 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.483 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.482 | |
| 3w8z | HTK | Putative FAD-dependent oxygenase EncM | / | 0.481 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.480 | |
| 5ahk | FAD | Acetolactate synthase II, large subunit | / | 0.480 | |
| 1e1q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.478 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.478 | |
| 3ou6 | SAM | SAM-dependent methyltransferase | / | 0.477 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.476 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.475 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.474 | |
| 2c92 | TP6 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.474 | |
| 2ejz | SAH | Diphthine synthase | / | 0.474 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.474 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.473 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 2clh | F19 | Tryptophan synthase alpha chain | / | 0.471 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.471 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.471 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 5kf2 | ACO | Predicted acetyltransferase | / | 0.470 | |
| 1fcx | 184 | Retinoic acid receptor gamma | / | 0.469 | |
| 3ozs | OZS | Catechol O-methyltransferase | 2.1.1.6 | 0.469 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2ony | TMJ | Phenylethanolamine N-methyltransferase | 2.1.1.28 | 0.468 | |
| 2vxk | COA | Glucosamine 6-phosphate acetyltransferase, putative | / | 0.468 | |
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 3qp8 | HL0 | Transcriptional activator, LuxR/UhpA family of regulators | / | 0.468 | |
| 4uaj | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.468 | |
| 2x20 | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.467 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.467 | |
| 4lb2 | DM5 | Serum albumin | / | 0.467 | |
| 5je2 | SAH | Methyl transferase | / | 0.467 | |
| 3dp9 | BIG | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.466 | |
| 3iis | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.466 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.466 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.465 | |
| 3iex | GMP | Purine nucleoside phosphorylase | / | 0.465 | |
| 3up0 | D7S | aceDAF-12 | / | 0.465 | |
| 4a39 | GEM | Uncharacterized protein | / | 0.465 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.465 | |
| 4gcx | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.465 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1fxu | GU7 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.464 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.464 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.464 | |
| 4rgs | V55 | Repressor protein | / | 0.464 | |
| 1ozq | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.463 | |
| 1qtq | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.463 | |
| 1rgs | CMP | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.463 | |
| 1syn | F89 | Thymidylate synthase | / | 0.463 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.463 | |
| 3hqd | ANP | Kinesin-like protein KIF11 | / | 0.463 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.463 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.463 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.462 | |
| 1nc1 | MTH | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.462 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 2ji9 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.462 | |
| 2y53 | NAP | 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase | / | 0.462 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.462 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.462 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.462 | |
| 4h7z | GUN | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.462 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.462 | |
| 2zsc | BTN | Tamavidin2 | / | 0.461 | |
| 4bue | JQF | Tankyrase-2 | 2.4.2.30 | 0.461 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.461 | |
| 1sqp | MYX | Cytochrome b | / | 0.460 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.460 | |
| 3mhp | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.460 | |
| 3s41 | S41 | Glucokinase | 2.7.1.2 | 0.460 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.460 | |
| 4eh7 | IRG | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.460 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.460 | |
| 1u0w | STL | Chalcone synthase 2 | 2.3.1.74 | 0.459 | |
| 1ycg | FMN | Nitric oxide reductase | 1 | 0.459 | |
| 2jdc | CAO | Probable acetyltransferase | / | 0.459 | |
| 3v1u | HXC | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.459 | |
| 4af3 | VX6 | Aurora kinase B | 2.7.11.1 | 0.459 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 4dch | 4DC | Glucokinase | 2.7.1.2 | 0.459 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.459 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1k9s | FM2 | Purine nucleoside phosphorylase DeoD-type | / | 0.458 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1sqb | AZO | Cytochrome b | / | 0.458 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.458 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.458 | |
| 2onz | TMJ | Phenylethanolamine N-methyltransferase | 2.1.1.28 | 0.458 | |
| 2xk7 | 30E | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.458 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 3sr4 | TT8 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.458 | |
| 4biw | ANP | Sensor histidine kinase CpxA | / | 0.458 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.458 | |
| 4dm8 | REA | Retinoic acid receptor beta | / | 0.458 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.458 | |
| 4v01 | 0LI | Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b | / | 0.458 | |
| 1dtp | APU | Diphtheria toxin | / | 0.457 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 1zz1 | SHH | Histone deacetylase-like amidohydrolase | 3.5.1 | 0.457 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3jzf | JZK | Biotin carboxylase | 6.3.4.14 | 0.457 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.457 | |
| 4xug | F9F | Tryptophan synthase alpha chain | / | 0.457 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.456 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.456 | |
| 3hky | IX6 | Genome polyprotein | 2.7.7.48 | 0.456 | |
| 3i6r | J5Z | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.456 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.456 | |
| 3zrr | PXG | Serine-pyruvate aminotransferase (AgxT) | / | 0.456 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.456 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.456 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.455 | |
| 1kf6 | HQO | Fumarate reductase iron-sulfur subunit | 1.3.5.1 | 0.455 | |
| 1kf6 | HQO | Fumarate reductase subunit C | / | 0.455 | |
| 1kf6 | HQO | Fumarate reductase subunit D | / | 0.455 | |
| 1m9h | NAD | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.455 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.455 | |
| 2c9b | PUG | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.455 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.455 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.455 | |
| 2yhu | WHF | Pteridine reductase | / | 0.455 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.455 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.455 | |
| 3dlg | GWE | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 3n87 | N87 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.455 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.455 | |
| 4jxx | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.455 | |
| 1jjt | BDS | Beta-lactamase | / | 0.454 | |
| 1k8z | IAG | Tryptophan synthase alpha chain | / | 0.454 | |
| 1zos | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.454 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.454 | |
| 2x21 | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.454 | |
| 3abi | NAD | Uncharacterized protein | / | 0.454 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.454 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.454 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.454 | |
| 4kdr | SAH | Ubiquinone biosynthesis O-methyltransferase | / | 0.454 | |
| 5bsr | COA | 4-coumarate--CoA ligase 2 | 6.2.1.12 | 0.454 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.454 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.453 | |
| 2mji | KTR | Fatty acid-binding protein, intestinal | / | 0.453 | |
| 2obf | F83 | Phenylethanolamine N-methyltransferase | 2.1.1.28 | 0.453 | |
| 2pjl | 047 | Steroid hormone receptor ERR1 | / | 0.453 | |
| 2wba | FAD | Trypanothione reductase | 1.8.1.12 | 0.453 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.453 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.453 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 4hlf | 15Z | Tankyrase-2 | 2.4.2.30 | 0.453 | |
| 4ixc | 1JD | Glucokinase | 2.7.1.2 | 0.453 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.452 | |
| 1pr4 | MTP | Purine nucleoside phosphorylase DeoD-type | / | 0.452 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.452 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.452 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.452 | |
| 3acy | 702 | Dehydrosqualene synthase | / | 0.452 | |
| 3e8x | NAP | BH1520 protein | / | 0.452 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.452 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3p9t | TCL | Repressor | / | 0.452 | |
| 3t0k | DCQ | Sulfide-quinone reductase | / | 0.452 | |
| 4afe | GGY | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.452 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4hlh | 20D | Tankyrase-2 | 2.4.2.30 | 0.452 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1fcy | 564 | Retinoic acid receptor gamma | / | 0.451 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.451 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.451 | |
| 2g8n | F83 | Phenylethanolamine N-methyltransferase | 2.1.1.28 | 0.451 | |
| 2qry | TPS | Thiamine-binding periplasmic protein | / | 0.451 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.451 | |
| 3dmj | GWE | Pol protein | / | 0.451 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 3ou7 | SAM | SAM-dependent methyltransferase | / | 0.451 | |
| 3uwo | 0DJ | Thymidylate kinase | 2.7.4.9 | 0.451 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4bus | 32F | Tankyrase-2 | 2.4.2.30 | 0.451 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.450 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.450 | |
| 3jq6 | DX1 | Pteridine reductase, putative | / | 0.450 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 3t9i | 3T9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.450 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.449 | |
| 2ban | 357 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.449 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.449 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.449 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 4e2y | JHZ | Methyltransferase | / | 0.449 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.449 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.449 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.449 | |
| 4phl | PIL | Phosphodiesterase | / | 0.449 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.448 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1wl4 | COA | Acetyl-CoA acetyltransferase, cytosolic | 2.3.1.9 | 0.448 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.448 | |
| 2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.448 | |
| 2wpw | ACO | Orf14 | / | 0.448 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.448 | |
| 3fmz | 2T1 | Retinol-binding protein 4 | / | 0.448 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 3n1t | 5GP | Purine nucleoside phosphoramidase | / | 0.448 | |
| 3nwe | 662 | Catechol O-methyltransferase | 2.1.1.6 | 0.448 | |
| 3qly | 55V | Uncharacterized protein | / | 0.448 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.448 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.448 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.447 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1qip | GNB | Lactoylglutathione lyase | 4.4.1.5 | 0.447 | |
| 1sqq | OST | Cytochrome b | / | 0.447 | |
| 2obx | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | 2.5.1.78 | 0.447 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.447 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.447 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.447 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.447 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.447 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.446 | |
| 1dia | L24 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.446 | |
| 1el4 | CTZ | Obelin | / | 0.446 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.446 | |
| 1swe | BTN | Streptavidin | / | 0.446 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.446 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.446 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.446 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.446 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.446 | |
| 3vhm | NPK | Avidin | / | 0.446 | |
| 4b6s | 2HN | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.446 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4hqv | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.446 | |
| 4z9r | NAD | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.446 | |
| 1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.445 | |
| 1lke | DOG | Bilin-binding protein | / | 0.445 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.445 | |
| 1pke | 2FD | Purine nucleoside phosphorylase DeoD-type | / | 0.445 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.445 | |
| 3bjh | NBB | Odorant binding protein ASP1 | / | 0.445 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.445 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.445 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.445 | |
| 3wtj | TH4 | Acetylcholine-binding protein | / | 0.445 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.445 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.445 | |
| 4egn | TWO | Cytochrome P450 | / | 0.445 | |
| 4h8i | 11W | Glutamate receptor ionotropic, kainate 2 | / | 0.445 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4kzl | 20D | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.445 | |
| 4rtb | SAM | Putative thiazole biosynthesis protein ThiH | / | 0.445 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.445 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1dib | L34 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.444 | |
| 1g60 | SAM | Modification methylase MboII | 2.1.1.72 | 0.444 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.444 | |
| 1kwc | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.444 | |
| 1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.444 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.444 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.444 | |
| 1zaf | 789 | Estrogen receptor beta | / | 0.444 | |
| 2e95 | B75 | Geranylgeranyl pyrophosphate synthase | / | 0.444 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.444 | |
| 2j5s | KTA | Alr4455 protein | / | 0.444 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.444 | |
| 3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.444 | |
| 3l70 | JZV | Cytochrome b | / | 0.444 | |
| 3occ | DIH | Purine nucleoside phosphorylase DeoD-type | / | 0.444 | |
| 3q0g | BCO | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.444 | |
| 4bb2 | STR | Corticosteroid-binding globulin | / | 0.444 | |
| 4bgi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 0.444 | |
| 4jd3 | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.444 | |
| 4jwr | 1MY | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.444 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 4u95 | MIY | Multidrug efflux pump subunit AcrB | / | 0.444 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.444 | |
| 1fxf | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.443 | |
| 1mjh | ATP | Universal stress protein MJ0577 | / | 0.443 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.443 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.443 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.443 | |
| 2op1 | 8PC | Enoyl-ACP reductase | / | 0.443 | |
| 2opb | F21 | Phenylethanolamine N-methyltransferase | 2.1.1.28 | 0.443 | |
| 2trs | IPL | Tryptophan synthase alpha chain | / | 0.443 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 3eku | CY9 | Actin-5C | / | 0.443 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.443 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3i68 | J4Z | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.443 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3up3 | XCA | aceDAF-12 | / | 0.443 | |
| 3vo3 | 0KF | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.443 | |
| 4amj | CVD | Beta-1 adrenergic receptor | / | 0.443 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.443 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.443 | |
| 5aku | 29F | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 1pr6 | XYA | Purine nucleoside phosphorylase DeoD-type | / | 0.442 | |
| 1q1g | MTI | Purine nucleoside phosphorylase | / | 0.442 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.442 | |
| 3d77 | NBB | Pheromone-binding protein ASP1 | / | 0.442 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3qck | NX5 | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.442 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.442 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4jv4 | 1OR | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.442 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.442 | |
| 5doz | NDP | JamJ | / | 0.442 | |
| 5i2h | AGI | O-methyltransferase family 2 | / | 0.442 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.442 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.441 | |
| 1mj3 | HXC | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.441 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.441 | |
| 1v48 | HA1 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1y5x | E89 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.441 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.441 | |
| 2h7j | H7J | Cathepsin S | 3.4.22.27 | 0.441 | |
| 2jj2 | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.441 | |
| 2jj2 | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 2mm3 | CHO | Gastrotropin | / | 0.441 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2y6d | TQJ | Matrilysin | 3.4.24.23 | 0.441 | |
| 3eei | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.441 | |
| 3gey | P34 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.441 | |
| 3w0u | HPW | Lactoylglutathione lyase | 4.4.1.5 | 0.441 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.441 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.441 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 4fj0 | HHF | 17beta-hydroxysteroid dehydrogenase | / | 0.441 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 4iwv | 1J9 | Glucokinase | 2.7.1.2 | 0.441 | |
| 4y1b | NAP | AntE | / | 0.441 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.441 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1ybg | TAV | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
| 1yin | CM3 | Estrogen receptor | / | 0.440 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.440 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 | |
| 2i62 | SAH | Nicotinamide N-methyltransferase | 2.1.1.1 | 0.440 | |
| 2jj1 | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.440 | |
| 2jj1 | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 3bld | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.440 | |
| 3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.440 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.440 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 4aoa | IK2 | Beta-phenylalanine transaminase | 2.6.1 | 0.440 | |
| 4gsu | DWZ | L,D-transpeptidase 2 | 2.3.2 | 0.440 | |
| 4hmh | F94 | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4iei | ADP | Gene 2 protein | / | 0.440 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.440 | |
| 4pl9 | ADP | Ethylene receptor 1 | / | 0.440 | |
| 4qii | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.440 | |
| 4qkn | JMS | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.440 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.440 |