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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.21.000
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.519
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.517
2yaaATPDeath-associated protein kinase 2/0.504
4fv6E57Mitogen-activated protein kinase 12.7.11.240.477
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.476
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.475
3zewSTUEphrin type-B receptor 42.7.10.10.475
4hge15VTyrosine-protein kinase JAK2/0.472
4jia1K3Tyrosine-protein kinase JAK2/0.469
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.466
4hvi19STyrosine-protein kinase JAK32.7.10.20.466
2vu3LZECyclin-dependent kinase 22.7.11.220.465
3lpbNVBTyrosine-protein kinase JAK2/0.465
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.460
3i60E86Mitogen-activated protein kinase 12.7.11.240.458
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.458
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.457
2ijmADPFocal adhesion kinase 12.7.10.20.456
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.456
4aqc88ATyrosine-protein kinase JAK2/0.455
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.455
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.452
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.452
2xvdAS6Ephrin type-B receptor 42.7.10.10.451
4bcmT7ZCyclin-dependent kinase 22.7.11.220.450
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.449
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.448
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.448
4i5cC5ITyrosine-protein kinase JAK1/0.447
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.447
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.445
3my5RFZCyclin-dependent kinase 22.7.11.220.445
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.445
4fv9E71Mitogen-activated protein kinase 12.7.11.240.444
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.443
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.441
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.440