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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3c5uP41Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3c5uP41Mitogen-activated protein kinase 14/1.000
3fknFKNMitogen-activated protein kinase 14/0.565
3fl4FL4Mitogen-activated protein kinase 14/0.556
2gfsPQBMitogen-activated protein kinase 14/0.540
3hub469Mitogen-activated protein kinase 14/0.518
3zsh469Mitogen-activated protein kinase 14/0.517
3ds6A17Mitogen-activated protein kinase 14/0.501
3fkoFKOMitogen-activated protein kinase 14/0.480
3uvqFS8Mitogen-activated protein kinase 14/0.477
4ih8B43Calmodulin-domain protein kinase 1/0.472
3mpaSB2Mitogen-activated protein kinase 14/0.469
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.461
4jy2FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.457
3hp552PMitogen-activated protein kinase 14/0.454
3hng8STVascular endothelial growth factor receptor 12.7.10.10.450
4nka2K7Fibroblast growth factor receptor 1/0.450
3itzP66Mitogen-activated protein kinase 14/0.446
2w4iVGAGlutamate racemase/0.445
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3h0sB38Acetyl-CoA carboxylase/0.444
3d7kD7KBenzaldehyde lyase/0.442
3almFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.441
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3iaeD7KBenzaldehyde lyase/0.440