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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.301.000
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.774
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.645
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.624
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.623
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.587
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.566
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.557
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.538
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.532
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.531
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.526
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.525
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.523
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.520
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.519
3l3lL3LPoly [ADP-ribose] polymerase 12.4.2.300.519
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.512
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.485
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.481
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.480
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.471
5ds309LPoly [ADP-ribose] polymerase 12.4.2.300.470
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.467
4pnmNU1Tankyrase-22.4.2.300.466
4tjy3GNTankyrase-22.4.2.300.454
4bj9UHBTankyrase-22.4.2.300.448
4je5PLPAromatic/aminoadipate aminotransferase 12.6.1.390.443