sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 1.000 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.567 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.541 | |
| 2wkm | PFY | Hepatocyte growth factor receptor | 2.7.10.1 | 0.540 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.538 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.532 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.532 | |
| 4gg5 | 0J3 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.521 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.520 | |
| 3f82 | 353 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.517 | |
| 4aoi | 4K0 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.513 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.509 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.508 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.506 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.505 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.504 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.503 | |
| 2xvv | 9DN | Serum albumin | / | 0.499 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.499 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.499 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.496 | |
| 4af3 | VX6 | Aurora kinase B | 2.7.11.1 | 0.496 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.495 | |
| 2xvw | 9NR | Serum albumin | / | 0.492 | |
| 3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.492 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.492 | |
| 1r0e | DFN | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.490 | |
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 | 0.490 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.489 | |
| 2pun | ACP | Methylthioribose kinase | 2.7.1.100 | 0.488 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.488 | |
| 3zbx | 6XE | Hepatocyte growth factor receptor | 2.7.10.1 | 0.487 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.486 | |
| 3b9l | AZZ | Serum albumin | / | 0.485 | |
| 4b8m | VX6 | Aurora kinase B-A | 2.7.11.1 | 0.485 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.485 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.485 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.485 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.484 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.484 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.484 | |
| 3qly | 55V | Uncharacterized protein | / | 0.484 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.484 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.484 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.483 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.483 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.483 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.482 | |
| 1xws | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.482 | |
| 4kao | KAO | Focal adhesion kinase 1 | 2.7.10.2 | 0.482 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.481 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.481 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.481 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.480 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.480 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.480 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.479 | |
| 2bil | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.479 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.479 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.479 | |
| 2ow3 | BIM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.479 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.479 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.478 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.478 | |
| 3c4e | C4E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.477 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.477 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.476 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.476 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.476 | |
| 3r02 | UNM | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.475 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.474 | |
| 2wqo | VGK | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.474 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.474 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.474 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.474 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.474 | |
| 4qna | X11 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.474 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.473 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.473 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.473 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.473 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.472 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.472 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.471 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.471 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.471 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.471 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.471 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.471 | |
| 4at5 | MUJ | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.471 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.471 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.471 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.470 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.470 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.470 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.470 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.470 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.470 | |
| 4lm5 | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.470 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.469 | |
| 1yi4 | ADN | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.469 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.469 | |
| 2bxq | IMN | Serum albumin | / | 0.469 | |
| 3bgz | VX3 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.469 | |
| 3nax | MP7 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.469 | |
| 4a99 | MIY | TetX family tetracycline inactivation enzyme | / | 0.469 | |
| 4c2w | ANP | Aurora kinase B-A | 2.7.11.1 | 0.469 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.469 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.469 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.468 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.468 | |
| 4a7c | E46 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.468 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.468 | |
| 4qmz | B49 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.468 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.468 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.467 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.467 | |
| 3jpv | 1DR | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.467 | |
| 3p5k | P5K | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.467 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.466 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.466 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.466 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.466 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.466 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.465 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.465 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.465 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.465 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.465 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.464 | |
| 3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.464 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.464 | |
| 4bwa | N0B | Pyrrolysine--tRNA ligase | / | 0.464 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.464 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1bq1 | CB3 | Thymidylate synthase | / | 0.463 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.463 | |
| 3cy3 | JN5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.463 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.463 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4e6a | 0O9 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.463 | |
| 4lmu | QUE | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.463 | |
| 4qo9 | 627 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.463 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.462 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.462 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.462 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4eil | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.462 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.462 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.462 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.461 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.461 | |
| 1zpr | CB3 | Thymidylate synthase | / | 0.461 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.461 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.461 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.461 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.461 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.461 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.461 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.461 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.461 | |
| 3vwd | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.461 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.461 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 5aaa | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.461 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.461 | |
| 1ga8 | UPF | LgtC | / | 0.460 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 2fto | TMP | Thymidylate synthase | / | 0.460 | |
| 3dcv | 55E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.460 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.460 | |
| 4dtk | 7LI | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.459 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.459 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.459 | |
| 2bfy | H1N | Aurora kinase B-A | 2.7.11.1 | 0.459 | |
| 3bgp | VX1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.459 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
| 3vjc | ZGA | Squalene synthase | 2.5.1.21 | 0.459 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.459 | |
| 5fsx | ADP | Uncharacterized protein | / | 0.459 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.458 | |
| 1ne4 | RP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.458 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.458 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.458 | |
| 2xiy | XIY | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.458 | |
| 3b5i | SAH | Indole-3-acetate O-methyltransferase 1 | / | 0.458 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.458 | |
| 3ce3 | 1FN | Hepatocyte growth factor receptor | 2.7.10.1 | 0.458 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.458 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.457 | |
| 2i0v | 6C3 | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.457 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.457 | |
| 4bch | T7Z | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.457 | |
| 4h1j | 0YH | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.457 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.457 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.456 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.456 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.456 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.456 | |
| 2xke | WI2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.456 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.456 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.456 | |
| 3iqf | E4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.456 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.456 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.456 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.456 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.455 | |
| 1m8h | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.455 | |
| 1osv | CHC | Bile acid receptor | / | 0.455 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.455 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.455 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.455 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.455 | |
| 2vmy | FFO | Serine hydroxymethyltransferase | / | 0.455 | |
| 2wgg | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.455 | |
| 2xiz | XIZ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.455 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.455 | |
| 3bhl | THG | Thymidylate synthase | / | 0.455 | |
| 3hv6 | R39 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3uix | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 3vw8 | DF6 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.455 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4i0t | 1B6 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.455 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.455 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.454 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.454 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.454 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 1yhs | STU | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.454 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.454 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.454 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.454 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.454 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 4k18 | 1OB | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.454 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.453 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1yi3 | LY2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.453 | |
| 2bxm | IMN | Serum albumin | / | 0.453 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.453 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.453 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.453 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 3ncg | BK1 | Calmodulin-domain protein kinase 1, putative | / | 0.453 | |
| 3up0 | D7S | aceDAF-12 | / | 0.453 | |
| 3upy | FOM | Oxidoreductase, putative | / | 0.453 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.453 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.453 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.453 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.452 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.452 | |
| 3q2m | CKI | Spectinomycin phosphotransferase | / | 0.452 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 4c8b | 0LI | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.452 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.452 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4u95 | MIY | Multidrug efflux pump subunit AcrB | / | 0.452 | |
| 5dgz | L20 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1v79 | FR7 | Adenosine deaminase | 3.5.4.4 | 0.451 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.451 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3gi3 | B10 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.451 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.451 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.451 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.450 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.450 | |
| 1lhv | NOG | Sex hormone-binding globulin | / | 0.450 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.450 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2gpu | OHT | Estrogen-related receptor gamma | / | 0.450 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 2qjy | SMA | Cytochrome b | / | 0.450 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 3vbq | 0F5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.450 | |
| 4j26 | EST | Estrogen receptor beta | / | 0.450 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.450 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.449 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3eej | 53R | Uncharacterized protein | / | 0.449 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.449 | |
| 3p79 | P79 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.449 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.449 | |
| 4cry | ACO | PanD regulatory factor | / | 0.449 | |
| 4egn | TWO | Cytochrome P450 | / | 0.449 | |
| 4gs4 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.449 | |
| 4iwd | 1JC | Hepatocyte growth factor receptor | 2.7.10.1 | 0.449 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.448 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 1yqd | NAP | Sinapyl alcohol dehydrogenase | / | 0.448 | |
| 2c6d | ANP | Aurora kinase A | 2.7.11.1 | 0.448 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.448 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2op1 | 8PC | Enoyl-ACP reductase | / | 0.448 | |
| 2qhn | 582 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.448 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.448 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.448 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3p9t | TCL | Repressor | / | 0.448 | |
| 3q9z | TXQ | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 3qwi | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.448 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3zqt | TES | Androgen receptor | / | 0.448 | |
| 4ans | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.448 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.448 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.448 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4i41 | MIX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.448 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.448 | |
| 4n6z | 2HW | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 1efa | NPF | Lactose operon repressor | / | 0.447 | |
| 1uu7 | BI2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.447 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.447 | |
| 2kce | D16 | Thymidylate synthase | / | 0.447 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2pmo | HMD | Protein kinase 7 | / | 0.447 | |
| 2w5b | AGS | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.447 | |
| 3dko | IHZ | Ephrin type-A receptor 7 | 2.7.10.1 | 0.447 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.447 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.447 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.447 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.447 | |
| 3vo3 | 0KF | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.447 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.447 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.447 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4anq | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.447 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.447 | |
| 4hvs | 647 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.447 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 4o4f | ATP | Kinase | / | 0.447 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.447 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.447 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1syn | F89 | Thymidylate synthase | / | 0.446 | |
| 1uu3 | LY4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.446 | |
| 2oiq | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.446 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.446 | |
| 2ylo | TES | Androgen receptor | / | 0.446 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.446 | |
| 3k3j | F4C | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3ma3 | 01I | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.446 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.446 | |
| 4ewq | MWL | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 4if5 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.446 | |
| 1dtp | APU | Diphtheria toxin | / | 0.445 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
| 2acx | ANP | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.445 | |
| 2etm | 7PY | Focal adhesion kinase 1 | 2.7.10.2 | 0.445 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.445 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.445 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.445 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.445 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 3epp | SFG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.445 | |
| 3h1j | SMA | Cytochrome b | / | 0.445 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.445 | |
| 3iqe | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.445 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 4f63 | 0S7 | Fibroblast growth factor receptor 1 | / | 0.445 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.445 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.445 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.445 | |
| 5c8d | 5AD | Probable transcriptional regulator | / | 0.445 | |
| 5dcy | NAP | Iridoid synthase | 1.3.1.99 | 0.445 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.445 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.445 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1hk5 | T44 | Serum albumin | / | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.444 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.444 | |
| 1uu8 | BI1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.444 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.444 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.444 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.444 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.444 | |
| 2puu | G2G | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.444 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.444 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.444 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.444 | |
| 3fnu | 006 | HAP protein | / | 0.444 | |
| 3jxw | LXG | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.444 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.444 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 4b1f | KRH | Glutamate racemase | / | 0.444 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.444 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.444 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4gqk | ADP | Actin cross-linking toxin VgrG1 | / | 0.444 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.444 | |
| 4kyh | ZST | Lactoylglutathione lyase | 4.4.1.5 | 0.444 | |
| 4qmt | H1N | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.444 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1e7w | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.443 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.443 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 1q4x | G24 | Thyroid hormone receptor beta | / | 0.443 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.443 | |
| 1xj7 | DHT | Androgen receptor | / | 0.443 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.443 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.443 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.443 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.443 | |
| 3ag9 | A02 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3cse | N22 | Uncharacterized protein | / | 0.443 | |
| 3dg8 | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3hzi | ATP | Serine/threonine-protein kinase toxin HipA | / | 0.443 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.443 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3up3 | XCA | aceDAF-12 | / | 0.443 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.443 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 4mbl | 26L | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 4oth | DRN | Serine/threonine-protein kinase N1 | / | 0.443 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.443 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.443 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.443 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 4v01 | 0LI | Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b | / | 0.443 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.443 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 1eio | GCH | Gastrotropin | / | 0.442 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.442 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.442 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.442 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.442 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1y5x | E89 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.442 | |
| 2hru | ADP | Phosphoribosylformylglycinamidine synthase subunit PurL | / | 0.442 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.442 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2xch | CKG | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3aba | FLI | Cytochrome P450 | / | 0.442 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.442 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.442 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4bl1 | ANP | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.442 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.442 | |
| 4f1m | ACP | Probable serine/threonine-protein kinase roco4 | 2.7.11.1 | 0.442 | |
| 4fob | 0US | ALK tyrosine kinase receptor | 2.7.10.1 | 0.442 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.442 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.442 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.442 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 4k1b | 1OC | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 4kxl | 6C6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.442 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.442 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.441 | |
| 1owp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.441 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.441 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 2i4t | UA2 | Purine nucleoside phosphorylase, putative | / | 0.441 | |
| 2pe2 | 464 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3c9t | TPS | Thiamine-monophosphate kinase | / | 0.441 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.441 | |
| 3p7b | P7B | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.441 | |
| 4jrv | KJV | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 4txi | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.441 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.440 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1fml | RTL | Retinol dehydratase | / | 0.440 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.440 | |
| 2owb | 626 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.440 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.440 | |
| 2xj1 | XJ1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.440 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.440 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.440 | |
| 3imx | B84 | Glucokinase | 2.7.1.2 | 0.440 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.440 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.440 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3vkj | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.440 | |
| 4ag8 | AXI | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.440 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.440 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.440 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.440 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.440 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.440 | |
| 4nmc | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.440 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.440 | |
| 5emh | NAP | Iridoid synthase | 1.3.1.99 | 0.440 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.440 | |
| 5je2 | SAH | Methyl transferase | / | 0.440 |