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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3c0zSHHHistone deacetylase 73.5.1.98

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3c0zSHHHistone deacetylase 73.5.1.981.000
3znrNU9Histone deacetylase 73.5.1.980.507
3c10TSNHistone deacetylase 73.5.1.980.502
3znsNU7Histone deacetylase 73.5.1.980.491
2rc6FADFerredoxin--NADP reductase/0.459
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.456
1a9cGTPGTP cyclohydrolase 13.5.4.160.452
1ahgTYR_PLPAspartate aminotransferase2.6.1.10.450
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.450
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1tkaN3TTransketolase 12.2.1.10.447
4bfwZVWPantothenate kinase2.7.1.330.446
3e6eDCSAlanine racemase/0.444
1b2lNDCAlcohol dehydrogenase1.1.1.10.443
1gtrATPGlutamine--tRNA ligase6.1.1.180.443
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.442
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.442
1x2bSTXProline iminopeptidase3.4.11.50.442
2xjeU5PCytosolic purine 5'-nucleotidase3.1.3.50.442
3rtnRTNBeta-secretase 13.4.23.460.442
4bftZVTPantothenate kinase2.7.1.330.442
2zevIPEGeranylgeranyl pyrophosphate synthase/0.441
4bfxZVXPantothenate kinase2.7.1.330.441
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440