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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3biz61EWee1-like protein kinase2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3biz61EWee1-like protein kinase2.7.10.21.000
3cr0809Wee1-like protein kinase2.7.10.20.819
2z2w770Wee1-like protein kinase2.7.10.20.728
2io6330Wee1-like protein kinase2.7.10.20.712
3cqeP91Wee1-like protein kinase2.7.10.20.688
1x8b824Wee1-like protein kinase2.7.10.20.664
3bi6396Wee1-like protein kinase2.7.10.20.647
2in6839Wee1-like protein kinase2.7.10.20.632
2yac937Serine/threonine-protein kinase PLK12.7.11.210.519
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.516
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.515
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.511
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.508
4qnaX11Serine/threonine-protein kinase 242.7.11.10.502
4riyADPEpidermal growth factor receptor2.7.10.10.494
4c02TAKActivin receptor type-12.7.11.300.489
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.488
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.488
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.487
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.487
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.486
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.486
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.486
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.485
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.485
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.484
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.483
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.482
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.482
4iarERM5-hydroxytryptamine receptor 1B/0.481
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.480
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.479
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.477
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.476
2wipP49Cyclin-dependent kinase 22.7.11.220.473
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.471
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.471
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.471
2vd5BI8Myotonin-protein kinase2.7.11.10.469
4jq8KJ8Epidermal growth factor receptor2.7.10.10.469
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.468
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.467
4gk3L87Ephrin type-A receptor 32.7.10.10.467
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.466
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
3to3ATPPetrobactin biosynthesis protein AsbB/0.465
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.464
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.464
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.464
3zewSTUEphrin type-B receptor 42.7.10.10.464
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.464
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.464
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.464
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.463
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.462
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.461
2j9lATPH(+)/Cl(-) exchange transporter 5/0.461
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.461
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.461
1hfqMOTDihydrofolate reductase1.5.1.30.460
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2owb626Serine/threonine-protein kinase PLK12.7.11.210.460
3zep1NXTyrosine-protein kinase JAK32.7.10.20.460
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.458
3c36KAIGlutamate receptor ionotropic, kainate 1/0.458
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.458
2yn8STUEphrin type-B receptor 42.7.10.10.457
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.457
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.456
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.456
3hz5Z64Heat shock protein HSP 90-alpha/0.456
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.456
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
2qo9ANPEphrin type-A receptor 32.7.10.10.455
2wkyIBCGlutamate receptor ionotropic, kainate 1/0.455
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.455
4c62XWWTyrosine-protein kinase JAK2/0.455
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.455
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.454
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.454
1u54ACPActivated CDC42 kinase 1/0.454
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2hog710Serine/threonine-protein kinase Chk12.7.11.10.454
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.454
1yqzCOACoenzyme A disulfide reductase/0.453
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.453
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.453
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.453
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.453
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.453
2i9kSAHModification methylase HhaI2.1.1.370.452
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.452
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.452
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.451
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2vrjNCWBeta-glucosidase A3.2.1.210.451
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.451
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.451
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.451
4wkqIREEpidermal growth factor receptor2.7.10.10.451
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.450
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.450
2gjnFMNNitronate monooxygenase1.13.12.160.450
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.450
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.450
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.450
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.450
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.450
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.450
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.450
5e8wSTUTGF-beta receptor type-12.7.11.300.450
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.449
1rw8580TGF-beta receptor type-12.7.11.300.449
2gjlFMNNitronate monooxygenase1.13.12.160.449
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.449
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.449
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.449
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.449
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.449
2ejzSAHDiphthine synthase/0.447
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.447
2itnANPEpidermal growth factor receptor2.7.10.10.447
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.447
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.447
4gmy0X5Tyrosine-protein kinase JAK2/0.447
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.446
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.446
3qakUKAAdenosine receptor A2a/0.446
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.445
4eb5PLPCysteine desulfurase IscS 2/0.445
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.445
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.444
4jr3KJREpidermal growth factor receptor2.7.10.10.444
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.443
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.443
2ittAEEEpidermal growth factor receptor2.7.10.10.443
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.443
4bfvZVVPantothenate kinase2.7.1.330.443
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.443
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.441
2hk51BMTyrosine-protein kinase HCK2.7.10.20.441
2xyuQ9GEphrin type-A receptor 42.7.10.10.441
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.441
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.441
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.441
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.441
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.441
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.440
2i0v6C3Macrophage colony-stimulating factor 1 receptor2.7.10.10.440
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.440
3ac1KZITyrosine-protein kinase Lck2.7.10.20.440
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.440
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.440
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.440
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.440
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.440
4jq7KJQEpidermal growth factor receptor2.7.10.10.440