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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3bc1GNPRas-related protein Rab-27A

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3bc1GNPRas-related protein Rab-27A/1.000
2zetGTPRas-related protein Rab-27B/0.605
3rabGNPRas-related protein Rab-3A/0.572
4lhwGNPRas-related protein Rab-8A/0.552
2gilGTPRas-related protein Rab-6A/0.536
3tsoGNPRas-related protein Rab-25/0.536
4cymGCPRas-related protein Rab-32/0.529
5dhaGNPGTP-binding nuclear protein Ran/0.524
3e5hGNPRas-related protein Rab-28/0.521
1g17GNPRas-related protein SEC4/0.508
3tnfGNPRas-related protein Rab-8A/0.493
3oesGNPGTPase RhebL1/0.491
1yzqGNPRas-related protein Rab-6A/0.488
2ffqGSPRas-related protein Rab-6B/0.485
1xtrGNPGTP-binding protein Rheb/0.483
1xtsGTPGTP-binding protein Rheb/0.481
3qbtGNPRas-related protein Rab-8A/0.479
5jljGNPGTP-binding nuclear protein Ran/0.478
1ibrGNPGTP-binding nuclear protein Ran/0.475
4o25GTPGTP-binding protein Rheb/0.475
1zbdGTPRas-related protein Rab-3A/0.469
1zc3GNPRas-related protein Ral-A/0.469
1kmqGNPTransforming protein RhoA/0.466
3lbnGNPGTPase HRas/0.464
1zc4GNPRas-related protein Ral-A/0.457
3rs5GNPGTPase HRas/0.455
4nyiGNPGTPase HRas/0.453
4rkfGNPRas-related protein Rab-3/0.448
1vg8GNPRas-related protein Rab-7a/0.447
3ea5GDPGTP-binding nuclear protein Ran/0.446
3oivGNPGTPase HRas/0.444
3w3zGTPGTP-binding nuclear protein Ran/0.444
5b2zGNPGTPase HRas/0.442