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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.11.000
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.554
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.549
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.503
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.484
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.477
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.476
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.470
3vs1VSATyrosine-protein kinase HCK2.7.10.20.464
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.462
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.461
3w2rW2REpidermal growth factor receptor2.7.10.10.460
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.447
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.447
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.445
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.445
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.442
4y93746Tyrosine-protein kinase/0.440