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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3b8q900Vascular endothelial growth factor receptor 22.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3b8q900Vascular endothelial growth factor receptor 22.7.10.11.000
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.678
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.547
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.525
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.506
3ctj320Hepatocyte growth factor receptor2.7.10.10.505
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.504
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.504
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.504
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.496
2hyySTITyrosine-protein kinase ABL12.7.10.20.488
3efl706Vascular endothelial growth factor receptor 22.7.10.10.485
3lfbZ87Mitogen-activated protein kinase 14/0.482
4eyjN61Mitogen-activated protein kinase 132.7.11.240.479
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.477
3hng8STVascular endothelial growth factor receptor 12.7.10.10.475
3ce31FNHepatocyte growth factor receptor2.7.10.10.469
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.469
2xir00JVascular endothelial growth factor receptor 22.7.10.10.466
4o2z046Mitogen-activated protein kinase/0.465
1iepSTITyrosine-protein kinase ABL12.7.10.20.463
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.460
4qrc0LIFibroblast growth factor receptor 42.7.10.10.459
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.448
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.448
4aa0AA0Mitogen-activated protein kinase 14/0.445
3hv5R24Mitogen-activated protein kinase 14/0.444