sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.818 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.814 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.766 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.764 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.759 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.757 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.738 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.730 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.728 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.725 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.724 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.712 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.708 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.703 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.703 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.693 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.693 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.690 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.690 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.688 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.687 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.686 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.686 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.684 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.682 | |
| 1i9m | INW | Carbonic anhydrase 2 | 4.2.1.1 | 0.681 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.677 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.675 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.675 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.673 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.673 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.673 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.664 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.664 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.663 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.662 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.658 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.657 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.652 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.652 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.647 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.647 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.645 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.644 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.642 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.631 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.631 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.630 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.628 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.626 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.625 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.622 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.618 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.614 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.609 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.609 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.608 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.605 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.605 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.599 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.598 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.598 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.597 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.594 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.591 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.590 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.583 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.583 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.576 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.575 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.575 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.572 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.569 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.567 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.555 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.554 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.554 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.552 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.551 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.550 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.550 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.546 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.546 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.546 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.542 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.541 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.540 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.539 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.539 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.535 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.535 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.535 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.533 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.533 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.533 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.533 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.531 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.530 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.527 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.527 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.523 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.517 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.516 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.507 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.507 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.502 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.501 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.496 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.490 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.490 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.489 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.487 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.485 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.482 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.481 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.481 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.480 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.479 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.478 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.474 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.473 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.472 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.472 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.472 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.471 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.471 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.471 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.471 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.471 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.469 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.469 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.469 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.469 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.468 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.468 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.468 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.468 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.467 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.467 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.467 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.467 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.467 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.467 | |
| 2wzw | NDP | Nitroreductase NfnB | / | 0.466 | |
| 1wze | NAD | Malate dehydrogenase | / | 0.465 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.465 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.465 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.464 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.464 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.464 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.464 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.463 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.463 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.463 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.462 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.462 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.462 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.461 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.461 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.460 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.460 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.460 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.460 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.459 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.459 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.459 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.459 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.459 | |
| 1c9w | NAP | Aldose reductase-related protein 2 | / | 0.458 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.458 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.457 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.457 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.457 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.457 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.456 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.456 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.456 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.456 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.456 | |
| 1c7o | PPG | Hemolysin | / | 0.455 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.455 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.455 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.455 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.455 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.454 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.454 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.454 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.454 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.454 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.454 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.454 | |
| 4rnu | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.454 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.454 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3kru | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.453 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.453 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.453 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.453 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.452 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.452 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.452 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.452 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.452 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.452 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.451 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.451 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.451 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.451 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.450 | |
| 3c1o | NAP | Eugenol synthase | / | 0.450 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.450 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.450 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.450 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.450 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.450 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.449 | |
| 2po3 | T4K | 4-dehydrase | / | 0.449 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.449 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.449 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.449 | |
| 4lut | DCS | Alanine racemase | / | 0.449 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.448 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.448 | |
| 2wqp | WQP | Polysialic acid capsule biosynthesis protein SiaC | / | 0.448 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.448 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4pgh | SAM | Caffeic acid O-methyltransferase | / | 0.448 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.447 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.447 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.447 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.447 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.447 | |
| 3ag6 | PAJ | Pantothenate synthetase | / | 0.447 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.447 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.447 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.447 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.447 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.447 | |
| 4jic | FMN | GTN Reductase | / | 0.447 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 1gpu | THD | Transketolase 1 | 2.2.1.1 | 0.446 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.446 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.446 | |
| 1zha | PEP | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.446 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.446 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.446 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.446 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.446 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.445 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.445 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.445 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.445 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.445 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.445 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.445 | |
| 1ee9 | NAD | Methylenetetrahydrofolate dehydrogenase [NAD(+)] | 1.5.1.15 | 0.444 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1vhz | APR | ADP compounds hydrolase NudE | 3.6.1 | 0.444 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.444 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.444 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.444 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.444 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4iah | 1DX | Alr2278 protein | / | 0.444 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.444 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.444 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.444 | |
| 4tmb | FMN | Old yellow enzyme | / | 0.444 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.444 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.444 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.443 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 1fml | RTL | Retinol dehydratase | / | 0.443 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.443 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.443 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.443 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.443 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.443 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.443 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 5fl4 | 9FK | Carbonic anhydrase 9 | 4.2.1.1 | 0.443 | |
| 1el4 | CTZ | Obelin | / | 0.442 | |
| 1ivs | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.442 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.442 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.442 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.442 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.441 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.441 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.441 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.441 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.441 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.441 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.441 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.441 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.441 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4h0v | NAD | Iota toxin component Ia | / | 0.441 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.441 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.440 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.440 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.440 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.440 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.440 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.440 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.440 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.440 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.440 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.440 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.440 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.440 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.440 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.440 |