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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3at3ATKCasein kinase II subunit alpha2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3at3ATKCasein kinase II subunit alpha2.7.11.11.000
4dgmAGICasein kinase II subunit alpha2.7.11.10.605
2pvlP55Casein kinase II subunit alpha2.7.11.10.601
2pvnP63Casein kinase II subunit alpha2.7.11.10.571
4anmWULCasein kinase II subunit alpha2.7.11.10.571
3be9P04Casein kinase II subunit alpha2.7.11.10.569
1m2qMNXCasein kinase II subunit alpha2.7.11.10.566
1lp4ANPCasein kinase II subunit alpha2.7.11.10.563
4dgo0JWCasein kinase II subunit alpha2.7.11.10.563
1m2rMNYCasein kinase II subunit alpha2.7.11.10.561
4dgnLU2Casein kinase II subunit alpha2.7.11.10.561
4grb0XGCasein kinase II subunit alpha2.7.11.10.556
4gub0Y4Casein kinase II subunit alpha2.7.11.10.555
2pvhP19Casein kinase II subunit alpha2.7.11.10.554
3owk18ECasein kinase II subunit alpha2.7.11.10.547
3q9xEMOCasein kinase II subunit alpha2.7.11.10.547
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.545
5cvhADPCasein kinase II subunit alpha2.7.11.10.544
1m2pHNACasein kinase II subunit alpha2.7.11.10.537
3u4uLNHCasein kinase II subunit alpha2.7.11.10.537
1dayGNPCasein kinase II subunit alpha2.7.11.10.529
1dawANPCasein kinase II subunit alpha2.7.11.10.525
1om1IQACasein kinase II subunit alpha2.7.11.10.523
5cshATPCasein kinase II subunit alpha2.7.11.10.523
2pvjP44Casein kinase II subunit alpha2.7.11.10.518
3at4CCKCasein kinase II subunit alpha2.7.11.10.518
3axwTIDCasein kinase II subunit alpha2.7.11.10.518
4jqeANPCasein kinase II subunit alpha2.7.11.10.516
4jr7GNPCasein kinase II subunit alpha2.7.11.10.512
3nga3NGCasein kinase II subunit alpha2.7.11.10.503
3nszANPCasein kinase II subunit alpha2.7.11.10.496
5cu6ATPCasein kinase II subunit alpha2.7.11.10.492
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.479
2iw84SPCyclin-dependent kinase 22.7.11.220.478
3wowANPCasein kinase II subunit alpha2.7.11.10.478
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.476
1xjdSTUProtein kinase C theta type2.7.11.130.476
2znpK55Peroxisome proliferator-activated receptor delta/0.475
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.474
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.474
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.472
2znq401Peroxisome proliferator-activated receptor delta/0.472
1e9hINRCyclin-dependent kinase 22.7.11.220.471
1k7l544Peroxisome proliferator-activated receptor alpha/0.470
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.468
2dwbANPAurora kinase A2.7.11.10.467
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.467
1oi9N20Cyclin-dependent kinase 22.7.11.220.466
2pvmP29Casein kinase II subunit alpha2.7.11.10.466
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.465
3sp9IL2Peroxisome proliferator-activated receptor delta/0.465
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.465
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.464
4jajXU1Aurora kinase A2.7.11.10.464
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.464
4mwhATPCasein kinase II subunit alpha2.7.11.10.464
1pjkANPCasein kinase II subunit alpha2.7.11.10.462
3q9zTXQCasein kinase II subunit alpha2.7.11.10.461
4lfiGNPCasein kinase II subunit alpha2.7.11.10.461
1di8DTQCyclin-dependent kinase 22.7.11.220.460
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.459
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.459
2zjwREFCasein kinase II subunit alpha2.7.11.10.458
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.457
3qqkX02Cyclin-dependent kinase 22.7.11.220.457
3sqq99ZCyclin-dependent kinase 22.7.11.220.457
1ke6LS2Cyclin-dependent kinase 22.7.11.220.456
2cchATPCyclin-dependent kinase 22.7.11.220.456
3eljGS7Mitogen-activated protein kinase 82.7.11.240.456
2xa4AZ5Tyrosine-protein kinase JAK2/0.455
3rmf20ZCyclin-dependent kinase 22.7.11.220.455
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.455
4fi1ATPCasein kinase II subunit alpha2.7.11.10.454
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.453
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.453
5dosATPAurora kinase A2.7.11.10.453
3owj1ELCasein kinase II subunit alpha2.7.11.10.452
4eok4SPCyclin-dependent kinase 22.7.11.220.452
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.452
1y0s331Peroxisome proliferator-activated receptor delta/0.451
2q9fC3SCholesterol 24-hydroxylase/0.450
4ez50RSCyclin-dependent kinase 62.7.11.220.450
4o0wADNAurora kinase A2.7.11.10.450
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.449
3uli1N3Cyclin-dependent kinase 22.7.11.220.449
4g170VNCasein kinase I isoform gamma-32.7.11.10.449
4neuQ1AReceptor-interacting serine/threonine-protein kinase 12.7.11.10.449
2h96893Mitogen-activated protein kinase 82.7.11.240.448
2uzbC75Cyclin-dependent kinase 22.7.11.220.448
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.448
3ral04ZCyclin-dependent kinase 22.7.11.220.448
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.448
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.448
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.447
1pyePM1Cyclin-dependent kinase 22.7.11.220.447
2excJNKMitogen-activated protein kinase 102.7.11.240.447
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.447
1urwI1PCyclin-dependent kinase 22.7.11.220.446
3pe2E1BCasein kinase II subunit alpha2.7.11.10.446
4fkw62KCyclin-dependent kinase 22.7.11.220.446
4hvh19RTyrosine-protein kinase JAK32.7.10.20.446
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.446
5dr9SKEAurora kinase A2.7.11.10.446
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.445
2iw94SPCyclin-dependent kinase 22.7.11.220.445
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.445
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.445
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.445
3rak03ZCyclin-dependent kinase 22.7.11.220.445
3zewSTUEphrin type-B receptor 42.7.10.10.445
4hvg19QTyrosine-protein kinase JAK32.7.10.20.445
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.444
3s1h56ZCyclin-dependent kinase 22.7.11.220.444
4hvi19STyrosine-protein kinase JAK32.7.10.20.444
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.444
5dt0SKEAurora kinase A2.7.11.10.444
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.443
3owl19ECasein kinase II subunit alpha2.7.11.10.443
1j91TBSCasein kinase II subunit alpha2.7.11.10.442
1zhwHC2Oxysterol-binding protein homolog 4/0.442
2izsBRQCasein kinase I isoform gamma-32.7.11.10.442
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.442
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.442
3mb601ICasein kinase II subunit alpha2.7.11.10.442
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.442
3unk0BYCyclin-dependent kinase 22.7.11.220.442
4hgt15GCasein kinase I isoform delta2.7.11.10.442
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.442
1pkdUCNCyclin-dependent kinase 22.7.11.220.441
2eufLQQCyclin-dependent kinase 62.7.11.220.441
2z97CAMCamphor 5-monooxygenase1.14.15.10.441
3v9v21LPeroxisome proliferator-activated receptor gamma/0.441
4c62XWWTyrosine-protein kinase JAK2/0.441
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.441
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.441
4riyADPEpidermal growth factor receptor2.7.10.10.441
5dr6SKEAurora kinase A2.7.11.10.441
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.440
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.440
3vt9YI4Vitamin D3 receptor/0.440
4bgh3I6Cyclin-dependent kinase 22.7.11.220.440
4eon1ROCyclin-dependent kinase 22.7.11.220.440
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.440
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.440
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.440