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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zb3NDPProstaglandin reductase 21.3.1.48

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2zb3NDPProstaglandin reductase 21.3.1.481.000
2vnaNAPProstaglandin reductase 21.3.1.480.576
2c0cNAPProstaglandin reductase 310.473
2y05NAPProstaglandin reductase 1/0.461
4b7xNAPProbable oxidoreductase/0.461
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.457
2j3iNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.447
2j3kNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.442