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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yixYIXMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2yixYIXMitogen-activated protein kinase 14/1.000
1zzlTZYMitogen-activated protein kinase 14/0.601
3hub469Mitogen-activated protein kinase 14/0.587
3zsh469Mitogen-activated protein kinase 14/0.570
1ove358Mitogen-activated protein kinase 14/0.568
3gc9B45Mitogen-activated protein kinase 112.7.11.240.553
3fkoFKOMitogen-activated protein kinase 14/0.551
3ds6A17Mitogen-activated protein kinase 14/0.550
3d7zGK5Mitogen-activated protein kinase 14/0.540
1wbwLI4Mitogen-activated protein kinase 14/0.536
3itzP66Mitogen-activated protein kinase 14/0.536
3fl4FL4Mitogen-activated protein kinase 14/0.535
3e92G6AMitogen-activated protein kinase 14/0.529
3fknFKNMitogen-activated protein kinase 14/0.526
3fmmXI2Mitogen-activated protein kinase 14/0.526
3iw6PP0Mitogen-activated protein kinase 14/0.525
3lfeZ84Mitogen-activated protein kinase 14/0.524
2gtnLIEMitogen-activated protein kinase 14/0.521
3bx5304Mitogen-activated protein kinase 14/0.521
3kf7L9GMitogen-activated protein kinase 14/0.518
3o8tBMUMitogen-activated protein kinase 14/0.518
3fc152PMitogen-activated protein kinase 14/0.512
3hp552PMitogen-activated protein kinase 14/0.512
3mpaSB2Mitogen-activated protein kinase 14/0.511
3roc29AMitogen-activated protein kinase 14/0.511
3c5uP41Mitogen-activated protein kinase 14/0.510
3rinI2OMitogen-activated protein kinase 14/0.509
1zyjBI5Mitogen-activated protein kinase 14/0.507
3lfcZ86Mitogen-activated protein kinase 14/0.507
3s4qNK0Mitogen-activated protein kinase 14/0.507
1ouy094Mitogen-activated protein kinase 14/0.506
1w7h3IPMitogen-activated protein kinase 14/0.504
1zz2B11Mitogen-activated protein kinase 14/0.502
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.502
3zsi52PMitogen-activated protein kinase 14/0.502
2zb1GK4Mitogen-activated protein kinase 14/0.501
2gfsPQBMitogen-activated protein kinase 14/0.500
3iw7IPKMitogen-activated protein kinase 14/0.500
2bakAQZMitogen-activated protein kinase 14/0.499
3fln3FNMitogen-activated protein kinase 14/0.499
3fmn530Mitogen-activated protein kinase 14/0.499
3l8sBFFMitogen-activated protein kinase 14/0.499
4a9yAQZMitogen-activated protein kinase 14/0.499
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.498
3flsFLSMitogen-activated protein kinase 14/0.498
4eh70OOMitogen-activated protein kinase 14/0.498
4eh50OMMitogen-activated protein kinase 14/0.497
1ouk084Mitogen-activated protein kinase 14/0.496
3hllI45Mitogen-activated protein kinase 14/0.495
3iw5DF3Mitogen-activated protein kinase 14/0.495
2zb0GK3Mitogen-activated protein kinase 14/0.493
3pg3DG7Mitogen-activated protein kinase 14/0.492
3uleC69Actin-related protein 3/0.492
1m7qDQOMitogen-activated protein kinase 14/0.491
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.491
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.491
3hp2P36Mitogen-activated protein kinase 14/0.490
3iw8HIZMitogen-activated protein kinase 14/0.489
3t9i3T9Serine/threonine-protein kinase pim-12.7.11.10.489
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.488
2gtmLIDMitogen-activated protein kinase 14/0.487
4eh60ONMitogen-activated protein kinase 14/0.487
1reoFADL-amino-acid oxidase1.4.3.20.484
3mvl38PMitogen-activated protein kinase 14/0.484
3gc7B45Mitogen-activated protein kinase 14/0.483
3l8xN4DMitogen-activated protein kinase 14/0.481
2hcdBIVVitamin D3 receptor A/0.478
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.477
1ywrLI9Mitogen-activated protein kinase 14/0.476
2qd9LGFMitogen-activated protein kinase 14/0.476
3obgSB2Mitogen-activated protein kinase 14/0.476
5ai5BSUBifunctional epoxide hydrolase 23.1.3.760.476
1yw2PGJMitogen-activated protein kinase 14/0.475
2bxoOPBSerum albumin/0.475
3uvqFS8Mitogen-activated protein kinase 14/0.475
4az0S61Lysosomal protective protein3.4.16.50.475
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.475
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.475
3w5tLHPVitamin D3 receptor/0.474
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.474
4tyj0LIFibroblast growth factor receptor 42.7.10.10.474
2b1pAIZMitogen-activated protein kinase 102.7.11.240.473
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.473
3uibSB2Putative mitogen-activated protein kinase/0.473
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.473
1og5SWFCytochrome P450 2C9/0.472
3dt1P40Mitogen-activated protein kinase 14/0.472
3oc1BMUMitogen-activated protein kinase 14/0.472
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.472
3rmf20ZCyclin-dependent kinase 22.7.11.220.472
4aa5NQBMitogen-activated protein kinase 14/0.472
2ewaSB2Mitogen-activated protein kinase 14/0.471
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.471
3nww3NWMitogen-activated protein kinase 14/0.471
4dlj6RGMitogen-activated protein kinase 14/0.471
1pagFMPAntiviral protein I3.2.2.220.470
3u8w09JMitogen-activated protein kinase 14/0.470
4ia1BIVVitamin D3 receptor A/0.470
4looSB4Mitogen-activated protein kinase 14/0.470
4neuQ1AReceptor-interacting serine/threonine-protein kinase 12.7.11.10.470
4xe606UDihydrofolate reductase1.5.1.30.470
1rf9DBRCamphor 5-monooxygenase1.14.15.10.469
2baqPQBMitogen-activated protein kinase 14/0.469
3bv2P38Mitogen-activated protein kinase 14/0.469
3flwFLWMitogen-activated protein kinase 14/0.469
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.469
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
4ux9ANPMitogen-activated protein kinase 82.7.11.240.469
4wa9AXITyrosine-protein kinase ABL12.7.10.20.469
1sn5T3Transthyretin/0.468
2itzIREEpidermal growth factor receptor2.7.10.10.468
3bv3P39Mitogen-activated protein kinase 14/0.468
3vt5YI2Vitamin D3 receptor/0.468
4yx6FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.468
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.467
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.467
2ydoADNAdenosine receptor A2a/0.467
3fmkFMKMitogen-activated protein kinase 14/0.467
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.467
4ryvZEAProtein LlR18A/0.467
5k2cZMAAdenosine receptor A2a/0.467
2ghmLICMitogen-activated protein kinase 14/0.466
3hng8STVascular endothelial growth factor receptor 12.7.10.10.466
3hv3R49Mitogen-activated protein kinase 14/0.466
3tm5SFGUncharacterized protein/0.466
5i2hAGIO-methyltransferase family 2/0.466
1bl6SB6Mitogen-activated protein kinase 14/0.465
1uy7PU4Heat shock protein HSP 90-alpha/0.465
2fgiPD1Fibroblast growth factor receptor 1/0.465
2hb7O1CVitamin D3 receptor/0.465
3uzcT4EAdenosine receptor A2a/0.465
1pmn984Mitogen-activated protein kinase 102.7.11.240.464
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.464
4ia2BIVVitamin D3 receptor A/0.464
5k2bZMAAdenosine receptor A2a/0.464
1w83L11Mitogen-activated protein kinase 14/0.463
1ykdCMPAdenylate cyclase/0.463
3vo30KFVascular endothelial growth factor receptor 22.7.10.10.463
4lopSB4Mitogen-activated protein kinase 14/0.463
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.462
2ittAEEEpidermal growth factor receptor2.7.10.10.462
2jedLG8Protein kinase C theta type2.7.11.130.462
2yk2YJXHeat shock protein HSP 90-alpha/0.462
3c3dFO12-phospho-L-lactate transferase/0.462
3gcq1BUMitogen-activated protein kinase 14/0.462
4aa4QC0Mitogen-activated protein kinase 14/0.462
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.462
1vruAAPGag-Pol polyprotein2.7.7.490.461
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.461
3jwcEKBDihydrofolate reductase/0.461
3vt3VDXVitamin D3 receptor/0.461
1ictT44Transthyretin/0.460
1w06W05Isopenicillin N synthase1.21.3.10.460
2ban357Gag-Pol polyprotein2.7.7.490.460
2hasC3OVitamin D3 receptor/0.460
2rg5279Mitogen-activated protein kinase 14/0.460
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
3hl7I47Mitogen-activated protein kinase 14/0.460
3ntdFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.460
3oom507Activin receptor type-12.7.11.300.460
3uvp048Mitogen-activated protein kinase 14/0.460
3vtbTKAVitamin D3 receptor/0.460
4dphP65Bifunctional dihydrofolate reductase-thymidylate synthase/0.460
4iteTEYVitamin D3 receptor/0.460
1ie4T44Transthyretin/0.459
1me8RVPInosine-5'-monophosphate dehydrogenase/0.459
1t1sCBQ1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.459
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.459
2i0ePDSProtein kinase C beta type2.7.11.130.459
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.459
3cwkREACellular retinoic acid-binding protein 2/0.459
3vtcTK3Vitamin D3 receptor/0.459
3w0aDS5Vitamin D3 receptor/0.459
4fnyI3KALK tyrosine kinase receptor2.7.10.10.459
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.459
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.458
2yk2YJWHeat shock protein HSP 90-alpha/0.458
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.458
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.458
4ewqMWLMitogen-activated protein kinase 14/0.458
4hnf16WCasein kinase I isoform delta2.7.11.10.458
4nfn2KCTau-tubulin kinase 12.7.11.10.458
4o701QKBromodomain-containing protein 4/0.458
5cdtPFBAlcohol dehydrogenase E chain1.1.1.10.458
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.457
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.457
3ac2KSETyrosine-protein kinase Lck2.7.10.20.457
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.457
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.457
3vrwYS5Vitamin D3 receptor/0.457
3vt8YI3Vitamin D3 receptor/0.457
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.457
4eh3NARMitogen-activated protein kinase 14/0.457
4ia7BIVVitamin D3 receptor A/0.457
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.456
1txiTX5Vitamin D3 receptor/0.456
2bbqPFGThymidylate synthase/0.456
2yxuATPPyridoxal kinase2.7.1.350.456
3iphG11Mitogen-activated protein kinase 14/0.456
3uwlFOZThymidylate synthase/0.456
3w2o03PEpidermal growth factor receptor2.7.10.10.456
3w5rLOAVitamin D3 receptor/0.456
3wd7COAAcridone synthase/0.456
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.456
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.456
4iwc1GVEstrogen receptor/0.456
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.456
4uhrNGIAdenosine receptor A2a/0.456
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.455
1xkkFMMEpidermal growth factor receptor2.7.10.10.455
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.455
2z3uCRRCytochrome P450/0.455
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.455
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.455
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.455
4i5hG17Mitogen-activated protein kinase 12.7.11.240.455
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.455
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.455
1fbmRTLCartilage oligomeric matrix protein/0.454
1jpaANPEphrin type-B receptor 22.7.10.10.454
1k6tXN1Gag-Pol polyprotein3.4.23.160.454
1nq7ARLNuclear receptor ROR-beta/0.454
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.454
2ykeYKEHeat shock protein HSP 90-alpha/0.454
2ykiYKIHeat shock protein HSP 90-alpha/0.454
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.454
3eptFDAPutative FAD-monooxygenase/0.454
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.454
3p2oNADBifunctional protein FolD/0.454
3zuyTCHTransporter/0.454
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.454
4e8yIHAD-beta-D-heptose 7-phosphate kinase/0.454
4gg70J8Hepatocyte growth factor receptor2.7.10.10.454
4iarERM5-hydroxytryptamine receptor 1B/0.454
1tz8DESTransthyretin/0.453
2excJNKMitogen-activated protein kinase 102.7.11.240.453
2vbpVB1Isopenicillin N synthase1.21.3.10.453
2yjxYJXHeat shock protein HSP 90-alpha/0.453
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.453
3kvxFMYMitogen-activated protein kinase 102.7.11.240.453
3ukuC69Actin-related protein 3/0.453
3vt9YI4Vitamin D3 receptor/0.453
4f640S8Fibroblast growth factor receptor 1/0.453
4jlj1NMDeoxycytidine kinase2.7.1.740.453
4jv618FRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.453
4kxn6K62'-deoxynucleoside 5'-phosphate N-hydrolase 1/0.453
5uviZMAAdenosine receptor A2a/0.453
1ju6LYAThymidylate synthase2.1.1.450.452
1kzuRG1Light-harvesting protein B-800/850 alpha chain/0.452
1kzuRG1Light-harvesting protein B-800/850 beta chain/0.452
1lriCLRBeta-elicitin cryptogein/0.452
1osvCHCBile acid receptor/0.452
1sqvUHDCytochrome b/0.452
1x8lOXRRetinol dehydratase/0.452
1yqj6NPMitogen-activated protein kinase 14/0.452
2qocANPEphrin type-A receptor 32.7.10.10.452
2y60M8FIsopenicillin N synthase1.21.3.10.452
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
3fmh533Mitogen-activated protein kinase 14/0.452
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
3mvm39PMitogen-activated protein kinase 14/0.452
3q5kD1UHeat shock protein 83-1/0.452
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.452
4ia3BIVVitamin D3 receptor A/0.452
4ly91YYGlucokinase regulatory protein/0.452
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.451
1di8DTQCyclin-dependent kinase 22.7.11.220.451
1pkfEPDEpothilone C/D epoxidase1.140.451
1ppjSMACytochrome b/0.451
1s0zEB1Vitamin D3 receptor/0.451
2p15EZTEstrogen receptor/0.451
2po7CHDFerrochelatase, mitochondrial4.99.1.10.451
2uxuNARHTH-type transcriptional regulator TtgR/0.451
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
3gubGUBDeath-associated protein kinase 12.7.11.10.451
3tubFPUTyrosine-protein kinase SYK2.7.10.20.451
3w33W19Epidermal growth factor receptor2.7.10.10.451
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4f630S7Fibroblast growth factor receptor 1/0.451
4iui1GQEstrogen receptor/0.451
4mzuCOAWxcM-like protein/0.451
1ie8KH1Vitamin D3 receptor/0.450
1pp9SMACytochrome b/0.450
1sn0T44Transthyretin/0.450
1uyfPU1Heat shock protein HSP 90-alpha/0.450
2aibERGBeta-elicitin cinnamomin/0.450
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.450
2hamC33Vitamin D3 receptor/0.450
2xvdAS6Ephrin type-B receptor 42.7.10.10.450
2z97CAMCamphor 5-monooxygenase1.14.15.10.450
3flzFLZMitogen-activated protein kinase 14/0.450
3grySAMProbable ribosomal RNA small subunit methyltransferase A/0.450
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.450
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
3tqhNDPQuinone oxidoreductase/0.450
4gk4L90Ephrin type-A receptor 32.7.10.10.450
4gmy0X5Tyrosine-protein kinase JAK2/0.450
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.450
1bwlFMNNADPH dehydrogenase 11.6.99.10.449
1kyzFERCaffeic acid 3-O-methyltransferase2.1.1.680.449
1l2jETCEstrogen receptor beta/0.449
1phgMYTCamphor 5-monooxygenase1.14.15.10.449
1x2hLPALipoate-protein ligase A6.3.1.200.449
2aaxPDNMineralocorticoid receptor/0.449
2oh4GIGVascular endothelial growth factor receptor 22.7.10.10.449
2pvyACPFibroblast growth factor receptor 2/0.449
2q59240Peroxisome proliferator-activated receptor gamma/0.449
2vwz7X6Ephrin type-B receptor 42.7.10.10.449
2vx07X7Ephrin type-B receptor 42.7.10.10.449
2ydvNECAdenosine receptor A2a/0.449
3cxhSMACytochrome b/0.449
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.449
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.449
3tm4SAMUncharacterized protein/0.449
3vt65YIVitamin D3 receptor/0.449
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.449
4loqSB4Mitogen-activated protein kinase 14/0.449
5e8xSTUTGF-beta receptor type-12.7.11.300.449
1e7aPFLSerum albumin/0.448
1m13HYFNuclear receptor subfamily 1 group I member 2/0.448
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.448
1q1rFADPutidaredoxin reductase1.18.1.50.448
1qcjAPTAntiviral protein I3.2.2.220.448
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.448
2harOCCVitamin D3 receptor/0.448
2rg6287Mitogen-activated protein kinase 14/0.448
2vcmM11Isopenicillin N synthase1.21.3.10.448
3cd2MTXDihydrofolate reductase1.5.1.30.448
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
3fklFKLMitogen-activated protein kinase 14/0.448
3fmjFMJMitogen-activated protein kinase 14/0.448
3ttjJBIMitogen-activated protein kinase 102.7.11.240.448
4b8mVX6Aurora kinase B-A2.7.11.10.448
4bqh9VUUDP-N-acetylglucosamine pyrophosphorylase, putative/0.448
4g1z0VPVitamin D3 receptor A/0.448
4jk4DIUSerum albumin/0.448
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.448
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.448
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.448
1iwjCAMCamphor 5-monooxygenase1.14.15.10.447
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
1ppjANYCytochrome b/0.447
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2fwzH71Heat shock protein HSP 90-alpha/0.447
2hc4VDXVitamin D3 receptor A/0.447
2py3ACPFibroblast growth factor receptor 2/0.447
2zbzVDXVitamin D3 dihydroxylase/0.447
2znnS44Peroxisome proliferator-activated receptor alpha/0.447
3ac1KZITyrosine-protein kinase Lck2.7.10.20.447
3dr1C5DVitamin D3 receptor A/0.447
3gfeP37Mitogen-activated protein kinase 14/0.447
3nfaCBJGag-Pol polyprotein/0.447
3q92XNBKetohexokinase/0.447
3qudN3FMitogen-activated protein kinase 14/0.447
3zlmANPAdenosine monophosphate-protein transferase NmFic2.7.7.n10.447
3zoiM2WIsopenicillin N synthase1.21.3.10.447
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.447
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.447
5a3bAPRSIR2 family protein/0.447
3emlZMAAdenosine receptor A2a/0.447
1cjcFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.446
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.446
2cppCAMCamphor 5-monooxygenase1.14.15.10.446
2np9YE1(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase/0.446
2oorNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.446
3gkjHC3Niemann-Pick C1 protein/0.446
3njoPYVAbscisic acid receptor PYR1/0.446
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4ez72ANCyclin-dependent kinase 22.7.11.220.446
4iv41GSEstrogen receptor/0.446
4l8u9AZSerum albumin/0.446
4qysPLRTryptophan synthase beta chain 24.2.1.200.446
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.446
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.446
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
1uydPU8Heat shock protein HSP 90-alpha/0.445
2bxqIMNSerum albumin/0.445
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.445
2o2u738Mitogen-activated protein kinase 102.7.11.240.445
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3up3XCAaceDAF-12/0.445
3v0tATRPerakine reductase1.1.1.3170.445
3wsbRWZFarnesyltransferase, putative/0.445
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.445
4dscA8SAbscisic acid receptor PYL3/0.445
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.445
4g1d0VKVitamin D3 receptor A/0.445
4g1wG1WMitogen-activated protein kinase 82.7.11.240.445
4ie6UN9Alpha-ketoglutarate-dependent dioxygenase FTO/0.445
4ixgIXGDihydrofolate reductase1.5.1.30.445
4kba1QMCasein kinase I isoform delta2.7.11.10.445
4l4xNDPAmphI/0.445
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.445
5cdsPFBAlcohol dehydrogenase E chain1.1.1.10.445
1lhvNOGSex hormone-binding globulin/0.444
1nqmBTNStreptavidin/0.444
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.444
1zhzERGOxysterol-binding protein homolog 4/0.444
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
2hk51BMTyrosine-protein kinase HCK2.7.10.20.444
2ij7TPFMycocyclosin synthase1.14.21.90.444
2o7pNAPRiboflavin biosynthesis protein RibD/0.444
2q61SF1Peroxisome proliferator-activated receptor gamma/0.444
2vmyFFOSerine hydroxymethyltransferase/0.444
2y6fM9FIsopenicillin N synthase1.21.3.10.444
2ydwWSHBromodomain-containing protein 2/0.444
2zazGK1Mitogen-activated protein kinase 14/0.444
3dafFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.444
3i0rRT3Gag-Pol polyprotein2.7.7.490.444
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.444
3qa2XNAKetohexokinase/0.444
3stxBKAMethylketone synthase I/0.444
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.444
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.444
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.444
3wowANPCasein kinase II subunit alpha2.7.11.10.444
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.444
4ag8AXIVascular endothelial growth factor receptor 22.7.10.10.444
4btkDTQTau-tubulin kinase 12.7.11.10.444
4klrCHDFerrochelatase, mitochondrial4.99.1.10.444
4mv1ADPBiotin carboxylase6.3.4.140.444
4nks2M2Fibroblast growth factor receptor 1/0.444
4o71CPBBromodomain-containing protein 4/0.444
4rupH97Vitamin D3 receptor A/0.444
5e8wSTUTGF-beta receptor type-12.7.11.300.444
1db1VDXVitamin D3 receptor/0.443
1hetNADAlcohol dehydrogenase E chain1.1.1.10.443
1k6pXN3Gag-Pol polyprotein3.4.23.160.443
1ot7IU5Bile acid receptor/0.443
1rkxNADCDP-D-glucose-4,6-dehydratase/0.443
1t47NTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.443
1xddAAYIntegrin alpha-L/0.443
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.443
2ociTYCValacyclovir hydrolase3.10.443
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.443
2x7gPVBSRSF protein kinase 22.7.11.10.443
2zlcVDXVitamin D3 receptor/0.443
3anlNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.443
3da1FADGlycerol-3-phosphate dehydrogenase/0.443
3gwfNAPCyclohexanone monooxygenase/0.443
3nr4PYVAbscisic acid receptor PYL2/0.443
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.443
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.443
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4dsbA8SAbscisic acid receptor PYL3/0.443
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4g2fC07Ephrin type-A receptor 32.7.10.10.443
4kiq1RAMitogen-activated protein kinase 14/0.443
4l2yXXKPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.443
4wloNAIMalate dehydrogenase, mitochondrial1.1.1.370.443
4zs2FLUAlpha-ketoglutarate-dependent dioxygenase FTO/0.443
5ab6CAANonspecific lipid-transfer protein, putative/0.443
1c0fATPMajor actin/0.442
1vj3TABDihydrofolate reductase1.5.1.30.442
2ghlLIBMitogen-activated protein kinase 14/0.442
2hb8MVDVitamin D3 receptor/0.442
2hq9FADMll6688 protein/0.442
2izrBRKCasein kinase I isoform gamma-32.7.11.10.442
2w6oOA3Biotin carboxylase6.3.4.140.442
3flyFLYMitogen-activated protein kinase 14/0.442
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.442
3o0iP54Heat shock protein HSP 90-alpha/0.442
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.442
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.442
3vrtYS2Vitamin D3 receptor/0.442
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.442
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.442
4cjwCBJIntegrase/0.442
4fhh0U3Vitamin D3 receptor A/0.442
4fhi0S4Vitamin D3 receptor A/0.442
4fki09KCyclin-dependent kinase 22.7.11.220.442
4g210VPVitamin D3 receptor A/0.442
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4iaq2GM5-hydroxytryptamine receptor 1B/0.442
4itfTFYVitamin D3 receptor/0.442
4nb6444Nuclear receptor ROR-gamma/0.442
4nh82LCHeat shock protein HSP 90-alpha/0.442
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1dkfBMSRetinoic acid receptor alpha/0.441
1dnaCB3Thymidylate synthase/0.441
1hquHBYGag-Pol polyprotein2.7.7.490.441
1lb9DNQGlutamate receptor 2/0.441
1n4hREANuclear receptor ROR-beta/0.441
1pdhFASp-hydroxybenzoate hydroxylase/0.441
1rx7FOLDihydrofolate reductase1.5.1.30.441
1uyePU9Heat shock protein HSP 90-alpha/0.441
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.441
2ibzSMACytochrome b/0.441
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.441
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.441
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3e5aVX6Aurora kinase A2.7.11.10.441
3f46I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.441
3fsfFSSMitogen-activated protein kinase 14/0.441
3nnuEDBMitogen-activated protein kinase 14/0.441
3o9zNADLipopolysaccaride biosynthesis protein wbpB/0.441
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.441
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.441
3vtdTKDVitamin D3 receptor/0.441
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.441
4ag5ADPType IV secretory pathway VirB4 components-like protein/0.441
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.441
4elh53IDihydrofolate reductase/0.441
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4ku5DCC3-oxoacyl-[ACP] synthase III/0.441
4mxeACON-acetyltransferase ESCO12.3.10.441
4zthGG5Mitogen-activated protein kinase 14/0.441
5c8d5ADProbable transcriptional regulator/0.441
5eypLOCTubulin beta chain/0.441
5jadFB2Platelet-activating factor acetylhydrolase3.1.1.470.441
5iua6DXAdenosine receptor A2a/0.441
1bq1CB3Thymidylate synthase/0.440
1chwHXCChalcone synthase 22.3.1.740.440
1draMTXDihydrofolate reductase1.5.1.30.440
1fvt106Cyclin-dependent kinase 22.7.11.220.440
1hvyD16Thymidylate synthase2.1.1.450.440
1i8tFADUDP-galactopyranose mutase5.4.99.90.440
1olmVTQSEC14-like protein 2/0.440
1rkgVD1Vitamin D3 receptor/0.440
1sozVAL_TYR_GLN_PHESerine endoprotease DegS3.4.21.1070.440
1uycPU7Heat shock protein HSP 90-alpha/0.440
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.440
2h55DZ8Heat shock protein HSP 90-alpha/0.440
2jblSMAReaction center protein L chain/0.440
2o4jVD4Vitamin D3 receptor/0.440
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.440
2vwy7X5Ephrin type-B receptor 42.7.10.10.440
2ykcYKCHeat shock protein HSP 90-alpha/0.440
2zbaZBATrichothecene 3-O-acetyltransferase/0.440
3fi4FI4Mitogen-activated protein kinase 14/0.440
3ictCOACoenzyme A disulfide reductase/0.440
3m6gATPActin, alpha skeletal muscle/0.440
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.440
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
3u2xASOGlycogenin-12.4.1.1860.440
3w0pADPHygromycin-B 4-O-kinase2.7.1.1630.440
4alhA9PBromodomain-containing protein 2/0.440
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.440
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.440
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4ea13RXDehydrosqualene synthase/0.440
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.440
4k9yK9YFocal adhesion kinase 12.7.10.20.440
4ruoBIVVitamin D3 receptor A/0.440
4tqqUQ1Reaction center protein L chain/0.440