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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yitYITSerine/threonine-protein kinase Chk22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2yitYITSerine/threonine-protein kinase Chk22.7.11.11.000
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.642
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.602
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.598
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.583
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.547
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.546
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.535
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.498
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.495
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.459
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.455