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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yisYISMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2yisYISMitogen-activated protein kinase 14/1.000
3p7bP7BMitogen-activated protein kinase 14/0.664
1kv2B96Mitogen-activated protein kinase 14/0.626
3p7cP7CMitogen-activated protein kinase 14/0.626
3p7aP7AMitogen-activated protein kinase 14/0.607
3o8uBMUMitogen-activated protein kinase 14/0.602
1kv1BMUMitogen-activated protein kinase 14/0.588
3hv6R39Mitogen-activated protein kinase 14/0.580
3uvr06FMitogen-activated protein kinase 14/0.554
1wbtWBTMitogen-activated protein kinase 14/0.550
3nnuEDBMitogen-activated protein kinase 14/0.549
3nnwEDDMitogen-activated protein kinase 14/0.545
3gcuR48Mitogen-activated protein kinase 14/0.542
1wbvLI3Mitogen-activated protein kinase 14/0.541
3lfbZ87Mitogen-activated protein kinase 14/0.533
3nnxEDDMitogen-activated protein kinase 14/0.518
3d83GK6Mitogen-activated protein kinase 14/0.513
1w82L10Mitogen-activated protein kinase 14/0.511
4eh90OQMitogen-activated protein kinase 14/0.510
1wbnL09Mitogen-activated protein kinase 14/0.509
3gcvSS6Mitogen-activated protein kinase 14/0.503
3hv4L51Mitogen-activated protein kinase 14/0.501
2e2b406Tyrosine-protein kinase ABL12.7.10.20.497
3hv71AUMitogen-activated protein kinase 14/0.493
3lffZ83Mitogen-activated protein kinase 14/0.492
3p5kP5KMitogen-activated protein kinase 14/0.491
1wbwLI4Mitogen-activated protein kinase 14/0.478
3npcB96Mitogen-activated protein kinase 92.7.11.240.475
3e9319BMitogen-activated protein kinase 14/0.472
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
3gcsBAXMitogen-activated protein kinase 14/0.464
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.461
5hidB1ESerine/threonine-protein kinase B-raf2.7.11.10.459
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
4dpwAGSMevalonate diphosphate decarboxylase/0.452
2qfxNDPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.451
3p78P78Mitogen-activated protein kinase 14/0.451
2yiwYIWMitogen-activated protein kinase 14/0.450
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.450
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.450
3nu3478Gag-Pol polyprotein3.4.23.160.449
2xclANPPhosphoribosylamine--glycine ligase/0.448
3dfcANPDeath-associated protein kinase 12.7.11.10.447
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.447
3v04V04Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.447
3v2wML5Sphingosine 1-phosphate receptor 1/0.446
2gr1FADFerredoxin reductase/0.445
3anlNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.443
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.441
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2v52LABActin, alpha skeletal muscle/0.441
3gi3B10Mitogen-activated protein kinase 14/0.441
3vhe42QVascular endothelial growth factor receptor 22.7.10.10.441
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.441