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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yfxVGHALK tyrosine kinase receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2yfxVGHALK tyrosine kinase receptor2.7.10.11.000
4anqVGHALK tyrosine kinase receptor2.7.10.10.723
5aaaVGHALK tyrosine kinase receptor2.7.10.10.719
4ansVGHALK tyrosine kinase receptor2.7.10.10.717
5aacVGHALK tyrosine kinase receptor2.7.10.10.660
4fob0USALK tyrosine kinase receptor2.7.10.10.563
5aabVGHALK tyrosine kinase receptor2.7.10.10.555
2xp2VGHALK tyrosine kinase receptor2.7.10.10.539
4cd0AWJALK tyrosine kinase receptor2.7.10.10.521
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.520
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.517
3w2o03PEpidermal growth factor receptor2.7.10.10.517
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.517
2c6eHPMAurora kinase A2.7.11.10.516
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.515
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.510
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.509
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.508
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.508
4b99R4LMitogen-activated protein kinase 72.7.11.240.507
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.506
3uvqFS8Mitogen-activated protein kinase 14/0.505
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.505
3a7hATPSerine/threonine-protein kinase 242.7.11.10.504
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.504
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.504
4g1wG1WMitogen-activated protein kinase 82.7.11.240.501
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.501
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.501
4nka2K7Fibroblast growth factor receptor 1/0.501
3vjoANPEpidermal growth factor receptor2.7.10.10.499
4id71G0Activated CDC42 kinase 1/0.499
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.498
2xb7GUIALK tyrosine kinase receptor2.7.10.10.498
2qoqANPEphrin type-A receptor 32.7.10.10.496
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.495
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.495
2j0m4STFocal adhesion kinase 12.7.10.20.492
1i44ACPInsulin receptor2.7.10.10.491
4qmlANPSerine/threonine-protein kinase 242.7.11.10.491
2qo7ANPEphrin type-A receptor 32.7.10.10.490
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.490
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.490
4gk4L90Ephrin type-A receptor 32.7.10.10.490
2ijmATPFocal adhesion kinase 12.7.10.20.487
2itnANPEpidermal growth factor receptor2.7.10.10.486
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.486
4nks2M2Fibroblast growth factor receptor 1/0.486
2henADPEphrin type-B receptor 22.7.10.10.485
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.484
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.484
4c62XWWTyrosine-protein kinase JAK2/0.483
3lctADPALK tyrosine kinase receptor2.7.10.10.482
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.482
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.481
2vrx447Aurora kinase B-A2.7.11.10.481
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.481
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.480
2j0lANPFocal adhesion kinase 12.7.10.20.480
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.480
4hyu1BKMitogen-activated protein kinase 82.7.11.240.480
4qo9627Serine/threonine-protein kinase 242.7.11.10.480
1u54ACPActivated CDC42 kinase 1/0.479
2qo9ANPEphrin type-A receptor 32.7.10.10.478
3op5REBSerine/threonine-protein kinase VRK12.7.11.10.478
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.478
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.478
4joa3DKALK tyrosine kinase receptor2.7.10.10.478
4o0uADNAurora kinase A2.7.11.10.478
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.477
2vwu7X1Ephrin type-B receptor 42.7.10.10.477
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.477
4ccuAWFALK tyrosine kinase receptor2.7.10.10.477
4i22IREEpidermal growth factor receptor2.7.10.10.477
2etm7PYFocal adhesion kinase 12.7.10.20.476
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.476
4gt3ATPMitogen-activated protein kinase 12.7.11.240.476
4gmy0X5Tyrosine-protein kinase JAK2/0.475
2hk51BMTyrosine-protein kinase HCK2.7.10.20.474
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.474
4gk3L87Ephrin type-A receptor 32.7.10.10.474
4jia1K3Tyrosine-protein kinase JAK2/0.474
2ghmLICMitogen-activated protein kinase 14/0.473
2ittAEEEpidermal growth factor receptor2.7.10.10.473
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.473
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.473
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.473
2of4979Tyrosine-protein kinase Lck2.7.10.20.472
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.472
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.471
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.471
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.470
4i231C9Epidermal growth factor receptor2.7.10.10.470
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.468
2xa4AZ5Tyrosine-protein kinase JAK2/0.467
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.467
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.467
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.466
2xvdAS6Ephrin type-B receptor 42.7.10.10.466
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.466
2ituITQEpidermal growth factor receptor2.7.10.10.465
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.465
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.465
3vryB43Tyrosine-protein kinase HCK2.7.10.20.465
3zewSTUEphrin type-B receptor 42.7.10.10.465
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.465
4y93746Tyrosine-protein kinase/0.465
2qocANPEphrin type-A receptor 32.7.10.10.464
2vgoAD5Aurora kinase B-A2.7.11.10.464
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.464
3e5aVX6Aurora kinase A2.7.11.10.464
3mpaSB2Mitogen-activated protein kinase 14/0.464
3w2sW2REpidermal growth factor receptor2.7.10.10.464
4jbqVX6Aurora kinase A2.7.11.10.464
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
2bfyH1NAurora kinase B-A2.7.11.10.463
4f630S7Fibroblast growth factor receptor 1/0.463
4fod0UVALK tyrosine kinase receptor2.7.10.10.463
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.462
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
2wqeADPAurora kinase A2.7.11.10.462
2x9fX9FEphrin type-B receptor 42.7.10.10.462
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.462
4eym0RXMitogen-activated protein kinase 132.7.11.240.462
4nk92K5Fibroblast growth factor receptor 1/0.462
4wkqIREEpidermal growth factor receptor2.7.10.10.462
2itqITQEpidermal growth factor receptor2.7.10.10.461
2py3ACPFibroblast growth factor receptor 2/0.461
4ccbOFGALK tyrosine kinase receptor2.7.10.10.461
1v9aSAHUncharacterized protein/0.460
4f640S8Fibroblast growth factor receptor 1/0.460
4j97ACPFibroblast growth factor receptor 2/0.460
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
2itzIREEpidermal growth factor receptor2.7.10.10.459
2pwlACPFibroblast growth factor receptor 2/0.459
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.459
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
4ic7ANPMitogen-activated protein kinase 72.7.11.240.459
4y95746Tyrosine-protein kinase/0.459
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.458
2ijmADPFocal adhesion kinase 12.7.10.20.458
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.458
2j7t274Serine/threonine-protein kinase 102.7.11.10.458
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.458
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.458
4c61LMMTyrosine-protein kinase JAK2/0.458
4jq8KJ8Epidermal growth factor receptor2.7.10.10.458
4riyADPEpidermal growth factor receptor2.7.10.10.458
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.457
2vgpAD6Aurora kinase B-A2.7.11.10.457
3l8p0CEAngiopoietin-1 receptor2.7.10.10.457
4k8aK8AFocal adhesion kinase 12.7.10.20.457
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.457
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.456
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.456
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.456
3a62STURibosomal protein S6 kinase beta-12.7.11.10.456
4ma628EAra h 8 allergen/0.456
4nxvGDPMitochondrial dynamics protein MID51/0.456
2hog710Serine/threonine-protein kinase Chk12.7.11.10.455
3w33W19Epidermal growth factor receptor2.7.10.10.455
1mqbANPEphrin type-A receptor 22.7.10.10.454
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.454
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.454
3gubGUBDeath-associated protein kinase 12.7.11.10.454
3t8oATPRhodopsin kinase/0.454
3ttiKBIMitogen-activated protein kinase 102.7.11.240.454
2itwITQEpidermal growth factor receptor2.7.10.10.453
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.453
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.453
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.453
4foc0UUALK tyrosine kinase receptor2.7.10.10.453
5e8xSTUTGF-beta receptor type-12.7.11.300.453
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.452
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.452
3vquO22Dual specificity protein kinase TTK2.7.12.10.452
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.452
4iebANPCalmodulin-domain protein kinase 1/0.452
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.452
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.452
2itvANPEpidermal growth factor receptor2.7.10.10.451
3pxkPXKFocal adhesion kinase 12.7.10.20.451
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.451
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.451
5l8lADPAurora kinase A2.7.11.10.451
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.450
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.450
3fkoFKOMitogen-activated protein kinase 14/0.450
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.450
4c4iX20Dual specificity protein kinase TTK2.7.12.10.450
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.450
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.449
3gc9B45Mitogen-activated protein kinase 112.7.11.240.449
4wboANWRhodopsin kinase/0.449
2j0j4STFocal adhesion kinase 12.7.10.20.448
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
2v7a627Tyrosine-protein kinase ABL12.7.10.20.447
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.447
3ttjJBIMitogen-activated protein kinase 102.7.11.240.447
3w18N13Aurora kinase A2.7.11.10.447
4b8mVX6Aurora kinase B-A2.7.11.10.447
4btkDTQTau-tubulin kinase 12.7.11.10.447
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.447
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.446
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.446
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.446
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.446
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.446
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.446
4aotGW8Serine/threonine-protein kinase 102.7.11.10.446
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.446
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.446
4jrvKJVEpidermal growth factor receptor2.7.10.10.446
5dr9SKEAurora kinase A2.7.11.10.446
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3emg685Tyrosine-protein kinase SYK2.7.10.20.445
3i60E86Mitogen-activated protein kinase 12.7.11.240.445
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.445
4lopSB4Mitogen-activated protein kinase 14/0.445
1jpaANPEphrin type-B receptor 22.7.10.10.444
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.444
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.444
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.444
4j95ACPFibroblast growth factor receptor 2/0.444
3hl7I47Mitogen-activated protein kinase 14/0.443
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.443
5awmANPStress-activated protein kinase JNK2.7.11.240.443
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.442
2j0k4STFocal adhesion kinase 12.7.10.20.442
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.442
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.442
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.442
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.442
3aoxEMHALK tyrosine kinase receptor2.7.10.10.442
3c4xATPRhodopsin kinase/0.442
4erwSTUCyclin-dependent kinase 22.7.11.220.442
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.442
4hvh19RTyrosine-protein kinase JAK32.7.10.20.442
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.441
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.441
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.441
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.441
4g2fC07Ephrin type-A receptor 32.7.10.10.441
4hys1BJMitogen-activated protein kinase 82.7.11.240.441
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.441
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.441
5e8wSTUTGF-beta receptor type-12.7.11.300.441
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.440
2itpAEEEpidermal growth factor receptor2.7.10.10.440
2of2547Tyrosine-protein kinase Lck2.7.10.20.440
2zmd537Dual specificity protein kinase TTK2.7.12.10.440
3vjnANPEpidermal growth factor receptor2.7.10.10.440
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.440
3zep1NXTyrosine-protein kinase JAK32.7.10.20.440