sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ye9 | 2D4 | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2ye9 | 2D4 | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.709 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.687 | |
| 2cct | 2E1 | Heat shock protein HSP 90-alpha | / | 0.672 | |
| 4egh | 0OY | Heat shock protein HSP 90-alpha | / | 0.643 | |
| 2yec | XQ0 | Heat shock protein HSP 90-alpha | / | 0.634 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.625 | |
| 2wi1 | ZZ2 | Heat shock protein HSP 90-alpha | / | 0.614 | |
| 2yjw | YJW | Heat shock protein HSP 90-alpha | / | 0.602 | |
| 2vci | 2GJ | Heat shock protein HSP 90-alpha | / | 0.583 | |
| 2yi6 | 6QM | Heat shock protein HSP 90-alpha | / | 0.577 | |
| 2ye4 | 2FY | Heat shock protein HSP 90-alpha | / | 0.572 | |
| 2uwd | 2GG | Heat shock protein HSP 90-alpha | / | 0.571 | |
| 2yi7 | BZ8 | Heat shock protein HSP 90-alpha | / | 0.570 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.569 | |
| 2wi2 | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.567 | |
| 3ft5 | MO8 | Heat shock protein HSP 90-alpha | / | 0.546 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.545 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.545 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.540 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.537 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.534 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.532 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.526 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.519 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.510 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.510 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.507 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.506 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.494 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.490 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.488 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.483 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.482 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.479 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.476 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.476 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.475 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 1qy8 | RDI | Endoplasmin | / | 0.468 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.466 | |
| 4b7p | 9UN | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 2xjj | L81 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 2o1v | ADP | Endoplasmin | / | 0.460 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 4bur | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.459 | |
| 2gew | FAD | Cholesterol oxidase | 1.1.3.6 | 0.458 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 1vcf | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.453 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.453 | |
| 1b4v | FAD | Cholesterol oxidase | 1.1.3.6 | 0.452 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.452 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3o3p | GDD | Glycosyl transferase, family 2 | / | 0.447 | |
| 2yhy | ADP | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase | 2.7.1.60 | 0.446 | |
| 2gfd | RDA | Endoplasmin | / | 0.445 | |
| 4bcp | T3C | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3dog | NNN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2ehu | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.443 | |
| 1n1p | FAD | Cholesterol oxidase | 1.1.3.6 | 0.442 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.442 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 1qax | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.440 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2xjg | XJG | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.440 |