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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.11.000
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.648
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.644
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.642
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.628
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.627
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.618
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.609
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.603
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.569
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.562
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.549
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.531
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.519
1jklANPDeath-associated protein kinase 12.7.11.10.504
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.495
4jboWPHAurora kinase A2.7.11.10.483
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.482
4jbpYPHAurora kinase A2.7.11.10.482
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.480
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.479
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.468
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.464
4wsqKSAAP2-associated protein kinase 12.7.11.10.464
1ig1ANPDeath-associated protein kinase 12.7.11.10.462
3k5uPFQAurora kinase A2.7.11.10.461
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.461
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.460
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.460
3bu5ATPInsulin receptor2.7.10.10.459
4jbqVX6Aurora kinase A2.7.11.10.459
2vrx447Aurora kinase B-A2.7.11.10.458
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.457
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.457
5av3KMPDeath-associated protein kinase 12.7.11.10.457
2c6eHPMAurora kinase A2.7.11.10.456
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.455
4o0uADNAurora kinase A2.7.11.10.455
2xvdAS6Ephrin type-B receptor 42.7.10.10.454
3ztxZTXAurora kinase B-A2.7.11.10.454
3w2sW2REpidermal growth factor receptor2.7.10.10.453
2yaaATPDeath-associated protein kinase 2/0.452
3bqr4RBDeath-associated protein kinase 3/0.452
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.452
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4ysjADPCalmodulin-like domain protein kinase/0.451
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.450
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.449
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.449
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
1jkkANPDeath-associated protein kinase 12.7.11.10.448
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.448
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.448
2w4jADPDeath-associated protein kinase 12.7.11.10.447
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.447
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.447
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.446
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.444
3hx4ANPCalmodulin-domain protein kinase 1/0.443
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.441
4i22IREEpidermal growth factor receptor2.7.10.10.441
2vgpAD6Aurora kinase B-A2.7.11.10.440