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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xvdAS6Ephrin type-B receptor 42.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2xvdAS6Ephrin type-B receptor 42.7.10.11.000
2x9fX9FEphrin type-B receptor 42.7.10.10.567
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.476
4gk4L90Ephrin type-A receptor 32.7.10.10.470
4jia1K3Tyrosine-protein kinase JAK2/0.463
3zewSTUEphrin type-B receptor 42.7.10.10.462
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.445
2qoqANPEphrin type-A receptor 32.7.10.10.445
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.440