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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xrwANPMitogen-activated protein kinase 82.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2xrwANPMitogen-activated protein kinase 82.7.11.241.000
3kvxFMYMitogen-activated protein kinase 102.7.11.240.596
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.509
2p33J07Mitogen-activated protein kinase 102.7.11.240.496
3cgfJNFMitogen-activated protein kinase 102.7.11.240.496
4ux9ANPMitogen-activated protein kinase 82.7.11.240.496
3cgoJNOMitogen-activated protein kinase 102.7.11.240.485
1jnkANPMitogen-activated protein kinase 102.7.11.240.480
2xs0ANPMitogen-activated protein kinase 82.7.11.240.474
3ttiKBIMitogen-activated protein kinase 102.7.11.240.470
1pmn984Mitogen-activated protein kinase 102.7.11.240.465
3orpAGSSerine/threonine protein kinase/0.463
4g1wG1WMitogen-activated protein kinase 82.7.11.240.462
4c4f7CEDual specificity protein kinase TTK2.7.12.10.460
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.459
4e730NRMitogen-activated protein kinase 82.7.11.240.458
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.456
1pmv537Mitogen-activated protein kinase 102.7.11.240.453
3i60E86Mitogen-activated protein kinase 12.7.11.240.453
4jbpYPHAurora kinase A2.7.11.10.450
4qnyANPMitogen activated protein kinase, putative/0.449
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.448
1bygSTUTyrosine-protein kinase CSK/0.445
1om1IQACasein kinase II subunit alpha2.7.11.10.445
4jboWPHAurora kinase A2.7.11.10.444
4dgnLU2Casein kinase II subunit alpha2.7.11.10.442
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
4btjATPTau-tubulin kinase 12.7.11.10.440
4j95ACPFibroblast growth factor receptor 2/0.440