Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xnoED8Serine/threonine-protein kinase Nek22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2xnoED8Serine/threonine-protein kinase Nek22.7.11.11.000
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.10.664
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.658
2xnpWCXSerine/threonine-protein kinase Nek22.7.11.10.611
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.606
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.601
2w5bAGSSerine/threonine-protein kinase Nek22.7.11.10.597
4afeGGYSerine/threonine-protein kinase Nek22.7.11.10.596
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.593
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.584
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.583
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.572
2jav5Z5Serine/threonine-protein kinase Nek22.7.11.10.567
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.561
2xk3XK3Serine/threonine-protein kinase Nek22.7.11.10.556
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.554
2yac937Serine/threonine-protein kinase PLK12.7.11.210.543
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.540
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.540
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.539
2owb626Serine/threonine-protein kinase PLK12.7.11.210.535
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.535
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.524
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.521
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.519
3h4vDVPPteridine reductase 11.5.1.330.519
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.518
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.512
2z2w770Wee1-like protein kinase2.7.10.20.511
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.509
3p0fBAUUridine phosphorylase 22.4.2.30.504
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.502
3cr0809Wee1-like protein kinase2.7.10.20.501
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.500
2bfpH4BPteridine reductase 11.5.1.330.499
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.495
2x9vTMQPteridine reductase/0.494
3h4vNAPPteridine reductase 11.5.1.330.494
1x8b824Wee1-like protein kinase2.7.10.20.492
3cqeP91Wee1-like protein kinase2.7.10.20.492
3bi6396Wee1-like protein kinase2.7.10.20.490
1blzACVIsopenicillin N synthase1.21.3.10.489
1d3dBZTProthrombin3.4.21.50.489
1kuyCOTSerotonin N-acetyltransferase/0.487
2y60M8FIsopenicillin N synthase1.21.3.10.487
2bfaCB3Pteridine reductase 11.5.1.330.486
2vbpVB1Isopenicillin N synthase1.21.3.10.486
2vcmM11Isopenicillin N synthase1.21.3.10.486
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.484
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.484
3emlZMAAdenosine receptor A2a/0.484
2bf7HBIPteridine reductase 11.5.1.330.483
1krv147Galactoside O-acetyltransferase2.3.1.180.482
2in6839Wee1-like protein kinase2.7.10.20.482
3zoiM2WIsopenicillin N synthase1.21.3.10.482
1efzPRFQueuine tRNA-ribosyltransferase2.4.2.290.480
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.480
2j9lATPH(+)/Cl(-) exchange transporter 5/0.480
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.480
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.480
1mj3HXCEnoyl-CoA hydratase, mitochondrial4.2.1.170.479
1nm6L86Prothrombin3.4.21.50.479
2w3aTOPDihydrofolate reductase1.5.1.30.479
3njoPYVAbscisic acid receptor PYR1/0.479
1q4wDQUQueuine tRNA-ribosyltransferase2.4.2.290.478
3pn1IVHDNA ligase/0.478
3zkyWT4Isopenicillin N synthase1.21.3.10.478
3fzsB96Protein-tyrosine kinase 2-beta2.7.10.20.477
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.477
4p9dTMPDeoxycytidylate deaminase/0.477
1e7wMTXPteridine reductase 11.5.1.330.476
2ejzSAHDiphthine synthase/0.476
3bw4FMNPutative 2-nitropropane dioxygenase/0.476
3n0yAPCAdenylate cyclase 2/0.476
1e92HBIPteridine reductase 11.5.1.330.475
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.475
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.475
1lv89PPPurine nucleoside phosphorylase2.4.2.10.473
1qjfACSIsopenicillin N synthase1.21.3.10.473
2oh4GIGVascular endothelial growth factor receptor 22.7.10.10.473
4hfp15UProthrombin3.4.21.50.473
4k9yK9YFocal adhesion kinase 12.7.10.20.473
5dp2NAPCurF/0.473
5iu86DZAdenosine receptor A2a/0.473
1fm69CRRetinoic acid receptor RXR-alpha/0.472
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.472
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.471
3qwc98PProthrombin3.4.21.50.471
4egnTWOCytochrome P450/0.471
4hvs647Mast/stem cell growth factor receptor Kit2.7.10.10.471
2vczVC3Hematopoietic prostaglandin D synthase/0.470
2wo7ASVIsopenicillin N synthase1.21.3.10.470
4fa30SLAldo-keto reductase family 1 member C3/0.470
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.470
3cth319Hepatocyte growth factor receptor2.7.10.10.469
3s41S41Glucokinase2.7.1.20.469
1c4uIH1Prothrombin3.4.21.50.468
1s3uTQDDihydrofolate reductase1.5.1.30.468
2bxqIMNSerum albumin/0.468
2qw8NAPEugenol synthase 11.1.1.3180.468
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.468
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.468
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.468
4f1oACPProbable serine/threonine-protein kinase roco42.7.11.10.468
4gqkADPActin cross-linking toxin VgrG1/0.468
1hb1OCVIsopenicillin N synthase1.21.3.10.467
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.467
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.467
1t57FMNConserved protein/0.466
2jh0701Prothrombin3.4.21.50.466
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.466
4dhyS41Glucokinase2.7.1.20.466
4f3gKAIGlutamate receptor 3/0.466
4fal0T0Aldo-keto reductase family 1 member C3/0.466
1qiwDPDCalmodulin/0.465
2y6fM9FIsopenicillin N synthase1.21.3.10.465
3ctj320Hepatocyte growth factor receptor2.7.10.10.465
3gkjHC3Niemann-Pick C1 protein/0.465
4n3l2FNProthrombin3.4.21.50.465
1disBDMDihydrofolate reductase1.5.1.30.464
1gj5130Prothrombin3.4.21.50.464
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.464
3x025GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.464
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.464
4stdBFSScytalone dehydratase4.2.1.940.464
4twnB96Ephrin type-A receptor 32.7.10.10.464
1dliUDXUDP-glucose 6-dehydrogenase/0.463
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
2puiADPMethylthioribose kinase2.7.1.1000.463
2vz0D64Pteridine reductase/0.463
3fhxPLPPyridoxal kinase2.7.1.350.463
3fkoFKOMitogen-activated protein kinase 14/0.463
4bfvZVVPantothenate kinase2.7.1.330.463
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
4pl9ADPEthylene receptor 1/0.463
5k2cZMAAdenosine receptor A2a/0.463
1mapKETAspartate aminotransferase, mitochondrial2.6.1.10.462
1w06W05Isopenicillin N synthase1.21.3.10.462
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
2hxdDUPdCTP deaminase, dUMP-forming3.5.4.300.462
2ydoADNAdenosine receptor A2a/0.462
2zs8ADPPantothenate kinase2.7.1.330.462
3g0eB49Mast/stem cell growth factor receptor Kit2.7.10.10.462
3h1vTK1Glucokinase2.7.1.20.462
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.462
5jtbZMAAdenosine receptor A2a/0.462
1qiqACCIsopenicillin N synthase1.21.3.10.461
3x2fNAIAdenosylhomocysteinase/0.461
4at4T6EBDNF/NT-3 growth factors receptor2.7.10.10.461
4bb3KKAIsopenicillin N synthase1.21.3.10.461
4gg90WWQueuine tRNA-ribosyltransferase2.4.2.290.461
1d3pBT3Prothrombin3.4.21.50.460
1x8lOXRRetinol dehydratase/0.460
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.460
3wv9FEGHmd co-occurring protein HcgE/0.460
4pnmNU1Tankyrase-22.4.2.300.460
5uviZMAAdenosine receptor A2a/0.460
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.459
1rd4L08Integrin alpha-L/0.459
1uhhCZPAequorin-2/0.459
1wl4COAAcetyl-CoA acetyltransferase, cytosolic2.3.1.90.459
2anmCDOProthrombin3.4.21.50.459
2ed3SAHDiphthine synthase/0.459
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.459
2io6330Wee1-like protein kinase2.7.10.20.459
2zs9ADPPantothenate kinase2.7.1.330.459
3tfyCOAN-alpha-acetyltransferase 502.3.10.459
5i2hAGIO-methyltransferase family 2/0.459
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.458
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.458
1pt8ACOFormyl-CoA:oxalate CoA-transferase/0.458
2h94FADLysine-specific histone demethylase 1A10.458
2iviACWIsopenicillin N synthase1.21.3.10.458
3gkiCLRNiemann-Pick C1 protein/0.458
3iktNADRedox-sensing transcriptional repressor Rex/0.458
3k47D09Dihydrofolate reductase1.5.1.30.458
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
3x0a5GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.458
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.458
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.458
1dtpAPUDiphtheria toxin/0.457
1kruIPTGalactoside O-acetyltransferase2.3.1.180.457
1p33MTXPteridine reductase 11.5.1.330.457
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.457
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.457
2a9z26AAdenosine kinase2.7.1.200.457
2yg4FADPutrescine oxidase/0.457
3eta351Insulin receptor2.7.10.10.457
3lm4HPXCatechol 2,3-dioxygenase/0.457
3p2oNADBifunctional protein FolD/0.457
3tubFPUTyrosine-protein kinase SYK2.7.10.20.457
1mu6CDAProthrombin3.4.21.50.456
1pd9CO4Dihydrofolate reductase1.5.1.30.456
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.456
2ewaSB2Mitogen-activated protein kinase 14/0.456
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.456
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.456
4fhd0TTSpore photoproduct lyase/0.456
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.456
4z87GDPInosine-5'-monophosphate dehydrogenase/0.456
1ascNPLAspartate aminotransferase2.6.1.10.455
1bk0ACVIsopenicillin N synthase1.21.3.10.455
1cqp803Integrin alpha-L/0.455
1hb3SCVIsopenicillin N synthase1.21.3.10.455
1ne4RP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.455
1o2g696Prothrombin3.4.21.50.455
1uzwCDHIsopenicillin N synthase1.21.3.10.455
2pksG44Prothrombin3.4.21.50.455
2rd2QSIGlutamine--tRNA ligase6.1.1.180.455
2w5aADPSerine/threonine-protein kinase Nek22.7.11.10.455
2yhuWHFPteridine reductase/0.455
3af1GDPPantothenate kinase2.7.1.330.455
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.455
3fsjD7KBenzoylformate decarboxylase4.1.1.70.455
3gcq1BUMitogen-activated protein kinase 14/0.455
3hfbML4Tryptophan 5-hydroxylase 11.14.16.40.455
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.455
4eevL1XHepatocyte growth factor receptor2.7.10.10.455
1diuBDMDihydrofolate reductase1.5.1.30.454
1jwtBLIProthrombin3.4.21.50.454
1obnASVIsopenicillin N synthase1.21.3.10.454
1u1d181Uridine phosphorylase2.4.2.30.454
2jb4A14Isopenicillin N synthase1.21.3.10.454
3djfBC3Purine nucleoside phosphorylase/0.454
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.454
3zkuHCVIsopenicillin N synthase1.21.3.10.454
3rfmCFFAdenosine receptor A2a/0.454
1n5vNOMActVA 6 protein/0.453
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.453
1wuuANPGalactokinase2.7.1.60.453
1xlsREARetinoic acid receptor RXR-alpha/0.453
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
2bu9HFVIsopenicillin N synthase1.21.3.10.453
2r2mI50Prothrombin3.4.21.50.453
2zhq27UProthrombin3.4.21.50.453
3cehAVEGlycogen phosphorylase, liver form2.4.1.10.453
5k2aZMAAdenosine receptor A2a/0.453
1odjGMPPurine nucleoside phosphorylase/0.452
1w87FADFerredoxin--NADP reductase1.18.1.20.452
2clfF6FTryptophan synthase alpha chain/0.452
2qqfA1RNAD-dependent protein deacetylase HST23.5.10.452
3b9lAZZSerum albumin/0.452
3fhxPXLPyridoxal kinase2.7.1.350.452
3ganSVRProtein RDM1/0.452
3new3NEMitogen-activated protein kinase 14/0.452
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.452
4fnyI3KALK tyrosine kinase receptor2.7.10.10.452
4iaq2GM5-hydroxytryptamine receptor 1B/0.452
4l17DNQGlutamate receptor 2/0.452
5iubCLRAdenosine receptor A2a/0.452
7catNDPCatalase1.11.1.60.452
1fmlRTLRetinol dehydratase/0.451
1n8wCOAMalate synthase G/0.451
1nqxRLP6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
1pnqNDPNAD(P) transhydrogenase subunit beta1.6.1.20.451
2bvs2CEProthrombin3.4.21.50.451
2cjfRP43-dehydroquinate dehydratase4.2.1.100.451
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.451
2gq3COAMalate synthase G/0.451
2jedLG8Protein kinase C theta type2.7.11.130.451
2r86ATP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase/0.451
3ghvGHCDihydrofolate reductase1.5.1.30.451
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
4bfwZVWPantothenate kinase2.7.1.330.451
4jpg1OXPyruvate kinase PKM2.7.1.400.451
4li61XOTankyrase-12.4.2.300.451
5iua6DXAdenosine receptor A2a/0.451
1dhfFOLDihydrofolate reductase1.5.1.30.450
1hfpMOTDihydrofolate reductase1.5.1.30.450
2bfmTOPPteridine reductase 11.5.1.330.450
2bo8GDXMannosylglycerate synthase/0.450
2e0nSAHPrecorrin-2 C20-methyltransferase/0.450
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.450
2rgjFADFlavin-containing monooxygenase/0.450
2uuk897Prothrombin3.4.21.50.450
2v3oI26Prothrombin3.4.21.50.450
3d76NBBPheromone-binding protein ASP1/0.450
3f0aACOSpermidine N(1)-acetyltransferase/0.450
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.450
4at0FADPossible succinate dehydrogenase/0.450
1h36R88Squalene--hopene cyclase4.2.1.1290.449
1k4hAPQQueuine tRNA-ribosyltransferase2.4.2.290.449
1mvsDTMDihydrofolate reductase1.5.1.30.449
1ne6SP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.449
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.449
1re0AFBADP-ribosylation factor 1/0.449
1re0AFBARF guanine-nucleotide exchange factor 1/0.449
2b03TUDPhospholipase A2, major isoenzyme3.1.1.40.449
2ojg19AMitogen-activated protein kinase 12.7.11.240.449
2vbdV10Isopenicillin N synthase1.21.3.10.449
2wn6NDPADP-ribosyltransferase enzymatic component/0.449
2xtbKRMAdenosine kinase, putative/0.449
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.449
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.449
4kfj1R0Dihydrofolate reductase1.5.1.30.449
4psbGA3Cytokinin-specific binding protein/0.449
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1oc1ASVIsopenicillin N synthase1.21.3.10.448
1s9pDESEstrogen-related receptor gamma/0.448
1t9c1SMAcetolactate synthase catalytic subunit, mitochondrial2.2.1.60.448
1w19T4P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
2hr8SAHDiphthine synthase/0.448
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.448
2zfq45UProthrombin3.4.21.50.448
3htjETEbrA repressor/0.448
3i5xANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.448
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3qbwADPAnhydro-N-acetylmuramic acid kinase/0.448
3vf60H6Glucokinase2.7.1.20.448
4c717RD3-oxoacyl-ACP synthase/0.448
4xt8TMQPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc/0.448
1b87ACOAac(6')-Ii protein/0.447
1bucFADAcyl-CoA dehydrogenase, short-chain specific1.3.8.10.447
1e2jTHMThymidine kinase/0.447
1xm1GAHProthrombin3.4.21.50.447
1z71L17Prothrombin3.4.21.50.447
2cn0F25Prothrombin3.4.21.50.447
3b04OOPIsopentenyl-diphosphate delta-isomerase/0.447
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.447
3zc3FADFerredoxin--NADP reductase1.18.1.20.447
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.447
4fw43P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.447
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.447
4m8e29VRetinoic acid receptor RXR-alpha/0.447
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.447
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.447
5iu4ZMAAdenosine receptor A2a/0.447
4u163C0Muscarinic acetylcholine receptor M3/0.447
3reyXACAdenosine receptor A2a/0.447
1h2bNAJNAD-dependent alcohol dehydrogenase/0.446
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.446
1mvcBM6Retinoic acid receptor RXR-alpha/0.446
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
1u0wSTLChalcone synthase 22.3.1.740.446
1u1gBBBUridine phosphorylase2.4.2.30.446
2bjsACVIsopenicillin N synthase1.21.3.10.446
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.446
3ekuCY9Actin-5C/0.446
3llaACPMyosin heavy chain kinase A2.7.11.70.446
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.446
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.445
1dr3TAPDihydrofolate reductase1.5.1.30.445
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.445
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.445
1u1cBAUUridine phosphorylase2.4.2.30.445
2dw4FADLysine-specific histone demethylase 1A10.445
2gbyBRNHTH-type transcriptional regulator QacR/0.445
2r6jNDPEugenol synthase 11.1.1.3180.445
2z1wBDIQueuine tRNA-ribosyltransferase2.4.2.290.445
2zc922UProthrombin3.4.21.50.445
3d74NBBPheromone-binding protein ASP1/0.445
3ebiBEYM1 family aminopeptidase3.4.110.445
3nxyD2HDihydrofolate reductase1.5.1.30.445
3sl2ATPSensor histidine kinase WalK/0.445
4bqyFNTEgl nine homolog 1/0.445
4dscA8SAbscisic acid receptor PYL3/0.445
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
5dstSAHProtein arginine N-methyltransferase 82.1.10.445
1mznBM6Retinoic acid receptor RXR-alpha/0.444
1ry0PG2Aldo-keto reductase family 1 member C3/0.444
1synF89Thymidylate synthase/0.444
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.444
2hkoFADLysine-specific histone demethylase 1A10.444
2og81N8Tyrosine-protein kinase Lck2.7.10.20.444
2qzrS79Queuine tRNA-ribosyltransferase2.4.2.290.444
2zhe13UProthrombin3.4.21.50.444
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.444
3p9kSAHCaffeic acid O-methyltransferase/0.444
4boeCLRJapanin/0.444
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.444
5g53NECAdenosine receptor A2a/0.444
1a4wQWEProthrombin3.4.21.50.443
1b2lNDCAlcohol dehydrogenase1.1.1.10.443
1bzfTMQDihydrofolate reductase1.5.1.30.443
1dr4HBIDihydrofolate reductase1.5.1.30.443
1h60STRPentaerythritol tetranitrate reductase/0.443
1ivrCBAAspartate aminotransferase, mitochondrial2.6.1.10.443
1pkfEPDEpothilone C/D epoxidase1.140.443
1ypmRA4Prothrombin3.4.21.50.443
2cy2ACOProbable acetyltransferase/0.443
2j4lUTPUridylate kinase2.7.4.220.443
2xviFADPutative flavin-containing monooxygenase/0.443
2z1xPRFQueuine tRNA-ribosyltransferase2.4.2.290.443
3adaNADSubunit alpha of sarocosine oxidase/0.443
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.443
3juqAKDPhenazine biosynthesis protein A/B/0.443
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.443
3tqxPLP2-amino-3-ketobutyrate coenzyme A ligase/0.443
3w2sW2REpidermal growth factor receptor2.7.10.10.443
3x03ANPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.443
4biwANPSensor histidine kinase CpxA/0.443
4g1nNZTPyruvate kinase PKM2.7.1.400.443
4gg1TZDBenzoylformate decarboxylase4.1.1.70.443
4k4eK4ETankyrase-12.4.2.300.443
5stdUNNScytalone dehydratase4.2.1.940.443
3uzcT4EAdenosine receptor A2a/0.443
1cq8PY6Aspartate aminotransferase2.6.1.10.442
1ej3CZHAequorin-2/0.442
1jdvADNPurine nucleoside phosphorylase/0.442
1k749CRRetinoic acid receptor RXR-alpha/0.442
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.442
1thnADPAnti-sigma F factor/0.442
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.442
2a9y26AAdenosine kinase2.7.1.200.442
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.442
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
2cf9348Prothrombin3.4.21.50.442
2gesCOKPantothenate kinase2.7.1.330.442
2gevCOKPantothenate kinase2.7.1.330.442
2z52H23Geranylgeranyl pyrophosphate synthase/0.442
2z71PNVPenicillin acylase3.5.1.110.442
3arzI5IChitinase A/0.442
3dg8NDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.442
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4zasTYDCalS13/0.442
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.290.441
1je1GMPPurine nucleoside phosphorylase/0.441
1nzq162Prothrombin3.4.21.50.441
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.441
1t4v14AProthrombin3.4.21.50.441
1uhlMEIRetinoic acid receptor RXR-beta/0.441
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.441
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.441
3b5iSAHIndole-3-acetate O-methyltransferase 1/0.441
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.441
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3gieACPSensor histidine kinase DesK2.7.13.30.441
3q60ATPRhoptry protein 5B/0.441
3up0D7SaceDAF-12/0.441
3uvvREARetinoic acid receptor RXR-alpha/0.441
3zbnCOA3-ketoacyl-CoA thiolase-like protein/0.441
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4c36ZO9cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4djw0KPBeta-secretase 13.4.23.460.441
4eqrCOACoenzyme A disulfide reductase/0.441
4gvsF4MMethenyltetrahydromethanopterin cyclohydrolase3.5.4.270.441
4ixc1JDGlucokinase2.7.1.20.441
4oeaDHTAndrogen receptor/0.441
5je2SAHMethyl transferase/0.441
1hfqMOTDihydrofolate reductase1.5.1.30.440
1ia4TQ6Dihydrofolate reductase1.5.1.30.440
1jtqLY3Thymidylate synthase/0.440
1qs2NADVip2Ac/0.440
1t9aYF4Acetolactate synthase catalytic subunit, mitochondrial2.2.1.60.440
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.440
1w83L11Mitogen-activated protein kinase 14/0.440
2culFADGidA-related protein/0.440
2lbdREARetinoic acid receptor gamma/0.440
2w3bNDPDihydrofolate reductase1.5.1.30.440
2zhf49UProthrombin3.4.21.50.440
2zozETTranscriptional regulator/0.440
3ix4TX1Transcriptional activator protein LasR/0.440
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.440
4a2aATPCell division protein FtsA/0.440
4a8v2ANMajor pollen allergen Bet v 1-J/0.440
4ap1NAPSteroid monooxygenase/0.440
4equG6ISerine/threonine-protein kinase 102.7.11.10.440
4h380YXDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.440
4ixd1HVIntegrin alpha-L/0.440
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.440
4pahLNRPhenylalanine-4-hydroxylase1.14.16.10.440