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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xk2ADPHeat shock protein HSP 90-alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
2xk2ADPHeat shock protein HSP 90-alpha/1.000
3t10ACPHeat shock protein HSP 90-alpha/0.668
3t2sAGSHeat shock protein HSP 90-alpha/0.666
1byqADPHeat shock protein HSP 90-alpha/0.643
2yegXQGHeat shock protein HSP 90-alpha/0.642
2iwuNP5ATP-dependent molecular chaperone HSP82/0.639
4egiB2JHeat shock protein HSP 90-alpha/0.631
3t1kANPHeat shock protein HSP 90-alpha/0.630
3vhaVHAHeat shock protein HSP 90-alpha/0.630
4gqtADPHeat shock protein 90/0.627
3r4pFU7Heat shock protein HSP 90-alpha/0.623
1am1ADPATP-dependent molecular chaperone HSP82/0.617
1yszNECEndoplasmin/0.617
3hhu819Heat shock protein HSP 90-alpha/0.617
4ce17FKATP-dependent molecular chaperone HSP82/0.617
4bqjXKLHeat shock protein HSP 90-alpha/0.615
2qg0A94Heat shock protein HSP 90-alpha/0.614
4ipeANPTNF receptor-associated protein 1/0.614
2byh2D7Heat shock protein HSP 90-alpha/0.612
4xcjADPHeat shock cognate 90 kDa protein/0.612
2yefANPHeat shock protein HSP 90-alpha/0.611
2xd6XD6ATP-dependent molecular chaperone HSP82/0.607
4fcr0TMHeat shock protein HSP 90-alpha/0.605
3ekrPY9Heat shock protein HSP 90-alpha/0.604
4ce2BO5ATP-dependent molecular chaperone HSP82/0.604
2byi2DDHeat shock protein HSP 90-alpha/0.603
4jqlVJ6Heat shock protein HSP 90-alpha/0.603
3k99PFTHeat shock protein HSP 90-alpha/0.602
1u2oNECEndoplasmin/0.599
1u0zRDCEndoplasmin/0.598
2bz5AB4Heat shock protein HSP 90-alpha/0.595
1yc34BCHeat shock protein HSP 90-alpha/0.594
2breKJ2ATP-dependent molecular chaperone HSP82/0.594
4b7p9UNHeat shock protein HSP 90-alpha/0.590
2xx213CATP-dependent molecular chaperone HSP82/0.588
4xclAGSHeat shock cognate 90 kDa protein/0.587
3r4oFU3Heat shock protein HSP 90-alpha/0.586
4xdmGDMHeat shock cognate 90 kDa protein/0.581
2xabVHDHeat shock protein HSP 90-alpha/0.579
3r4nFU5Heat shock protein HSP 90-alpha/0.578
5f5rANPHeat shock protein 75 kDa, mitochondrial/0.578
1amwADPATP-dependent molecular chaperone HSP82/0.577
4ivgANPTNF receptor-associated protein 1/0.576
2brcCT5ATP-dependent molecular chaperone HSP82/0.575
2xhtC0YHeat shock protein HSP 90-alpha/0.574
1qy8RDIEndoplasmin/0.573
2o1uANPEndoplasmin/0.573
3rlq3RQHeat shock protein HSP 90-alpha/0.573
3t0zATPHeat shock protein HSP 90-alpha/0.573
1yetGDMHeat shock protein HSP 90-alpha/0.572
2xcmADPCytosolic heat shock protein 90/0.572
3ekoPYUHeat shock protein HSP 90-alpha/0.568
1uy7PU4Heat shock protein HSP 90-alpha/0.566
2fypRDEEndoplasmin/0.564
2wepADPATP-dependent molecular chaperone HSP82/0.564
1yc14BCHeat shock protein HSP 90-alpha/0.562
2fxsRDAATP-dependent molecular chaperone HSP82/0.562
3hyz42CHeat shock protein HSP 90-alpha/0.561
2cgfP2NATP-dependent molecular chaperone HSP82/0.560
3k981RCHeat shock protein HSP 90-alpha/0.560
2xx413IATP-dependent molecular chaperone HSP82/0.558
2iwxM1SATP-dependent molecular chaperone HSP82/0.557
4xc0ACPHeat shock cognate 90 kDa protein/0.557
3k974CDHeat shock protein HSP 90-alpha/0.556
3rlr3RRHeat shock protein HSP 90-alpha/0.556
4as94QSATP-dependent molecular chaperone HSP82/0.556
2gqpPA7Endoplasmin/0.553
4asf62UATP-dependent molecular chaperone HSP82/0.553
1yc443PHeat shock protein HSP 90-alpha/0.552
1uyePU9Heat shock protein HSP 90-alpha/0.551
1y4sADPChaperone protein HtpG/0.551
1u0yPA7Endoplasmin/0.546
4asg814ATP-dependent molecular chaperone HSP82/0.546
4ce3L4VATP-dependent molecular chaperone HSP82/0.545
4egkRDCHeat shock protein HSP 90-alpha/0.545
3ft8MOJHeat shock protein HSP 90-alpha/0.544
4eftEFTHeat shock protein HSP 90-alpha/0.543
1qy5NECEndoplasmin/0.542
2bu8ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.542
1uy8PU5Heat shock protein HSP 90-alpha/0.541
1uymPU3Heat shock protein HSP 90-beta/0.540
2wi6ZZ6Heat shock protein HSP 90-alpha/0.540
3whaWHAHeat shock protein HSP 90-alpha/0.539
1bgqRDCATP-dependent molecular chaperone HSP82/0.538
2bt0CT5Heat shock protein HSP 90-alpha/0.538
3c11GDMATP-dependent molecular chaperone HSP82/0.538
1uyfPU1Heat shock protein HSP 90-alpha/0.537
2iwsNP4ATP-dependent molecular chaperone HSP82/0.537
4nh82LCHeat shock protein HSP 90-alpha/0.537
3hekBD0Heat shock protein HSP 90-alpha/0.536
2o1vADPEndoplasmin/0.535
2wi72KLHeat shock protein HSP 90-alpha/0.535
2yee2ECHeat shock protein HSP 90-alpha/0.535
3b28B2XHeat shock protein HSP 90-alpha/0.535
3iedAN2HSP90/0.535
2yjxYJXHeat shock protein HSP 90-alpha/0.534
2werRDCATP-dependent molecular chaperone HSP82/0.533
2xjxXJXHeat shock protein HSP 90-alpha/0.533
2ykiYKIHeat shock protein HSP 90-alpha/0.533
1osfKOSHeat shock protein HSP 90-alpha/0.532
2yi5YI5Heat shock protein HSP 90-alpha/0.532
2qfoA13Heat shock protein HSP 90-alpha/0.531
3d0bSNXHeat shock protein HSP 90-alpha/0.531
2hg1N5OEndoplasmin/0.530
2vw5BC6ATP-dependent molecular chaperone HSP82/0.529
3inwJZBHeat shock protein HSP 90-alpha/0.529
3pehIBDEndoplasmin homolog, putative/0.529
1yt0ADPEndoplasmin/0.528
2iorADPChaperone protein HtpG/0.528
2fwzH71Heat shock protein HSP 90-alpha/0.527
2hchN5AEndoplasmin/0.527
1uy9PU6Heat shock protein HSP 90-alpha/0.525
2esaGDMEndoplasmin/0.525
2gfdRDAEndoplasmin/0.525
2qg2A91Heat shock protein HSP 90-alpha/0.524
3hz142CHeat shock protein HSP 90-alpha/0.524
2xhrC0PHeat shock protein HSP 90-alpha/0.522
2ykeYKEHeat shock protein HSP 90-alpha/0.522
3o0iP54Heat shock protein HSP 90-alpha/0.522
1uykPUXHeat shock protein HSP 90-alpha/0.520
4bqg50QHeat shock protein HSP 90-alpha/0.520
2fwyH64Heat shock protein HSP 90-alpha/0.519
1uy6PU3Heat shock protein HSP 90-alpha/0.518
2wi5ZZ5Heat shock protein HSP 90-alpha/0.518
2ykbYKBHeat shock protein HSP 90-alpha/0.517
4hy6FJ1Heat shock protein HSP 90-alpha/0.516
1uydPU8Heat shock protein HSP 90-alpha/0.514
3inxJZCHeat shock protein HSP 90-alpha/0.514
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.513
3hz137DHeat shock protein HSP 90-alpha/0.513
3qdd94MHeat shock protein HSP 90-alpha/0.513
3q5lKX2Heat shock protein 83-1/0.512
1uyiPUZHeat shock protein HSP 90-alpha/0.511
2ykcYKCHeat shock protein HSP 90-alpha/0.509
2exlGDMEndoplasmin/0.508
2h55DZ8Heat shock protein HSP 90-alpha/0.503
2qfoA51Heat shock protein HSP 90-alpha/0.503
3rlp3RPHeat shock protein HSP 90-alpha/0.501
2ykjYKJHeat shock protein HSP 90-alpha/0.500
4efuEFUHeat shock protein HSP 90-alpha/0.500
1uycPU7Heat shock protein HSP 90-alpha/0.499
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.499
2wi4ZZ4Heat shock protein HSP 90-alpha/0.497
2xjjL81Heat shock protein HSP 90-alpha/0.496
2yk2YJXHeat shock protein HSP 90-alpha/0.495
3opdHIEHeat shock protein 83/0.494
2yejZZ3Heat shock protein HSP 90-alpha/0.493
1i59ANPChemotaxis protein CheA2.7.13.30.492
2vwcBC2ATP-dependent molecular chaperone HSP82/0.491
2q8iRDC[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial2.7.11.20.490
2yejXQKHeat shock protein HSP 90-alpha/0.490
2yk2YJWHeat shock protein HSP 90-alpha/0.490
1i58ADPChemotaxis protein CheA2.7.13.30.489
1nhhANPDNA mismatch repair protein MutL/0.489
2uwd2GGHeat shock protein HSP 90-alpha/0.488
4awp99AHeat shock protein HSP 90-alpha/0.488
2zkjADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.487
2yeiXQIHeat shock protein HSP 90-alpha/0.486
3o6o94MHeat shock protein 83/0.486
3q5kD1UHeat shock protein 83-1/0.486
3crlANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.484
4hjfC2EGGDEF family protein/0.483
1z59ADPType 2 DNA topoisomerase 6 subunit B/0.482
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.480
2vcj2EQHeat shock protein HSP 90-alpha/0.480
2bsmBSMHeat shock protein HSP 90-alpha/0.479
3pejBC2Endoplasmin homolog, putative/0.479
1i5aACPChemotaxis protein CheA2.7.13.30.477
2bu2ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.475
2yecXQ0Heat shock protein HSP 90-alpha/0.475
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.472
2wi1ZZ2Heat shock protein HSP 90-alpha/0.472
4awo99BHeat shock protein HSP 90-alpha/0.470
2zdxP4A[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.469
4egh0OYHeat shock protein HSP 90-alpha/0.468
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.468
2py3ACPFibroblast growth factor receptor 2/0.467
2yi7BZ8Heat shock protein HSP 90-alpha/0.467
2xx513NATP-dependent molecular chaperone HSP82/0.466
2ye42FYHeat shock protein HSP 90-alpha/0.466
4nxvGDPMitochondrial dynamics protein MID51/0.462
2xhxT5MHeat shock protein HSP 90-alpha/0.461
2yjwYJWHeat shock protein HSP 90-alpha/0.461
4lhtCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.461
3sl2ATPSensor histidine kinase WalK/0.459
1pvgANPDNA topoisomerase 25.99.1.30.458
1t2bCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.458
1jm6ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.457
1mx0ANPType 2 DNA topoisomerase 6 subunit B/0.456
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.456
1i5cADPChemotaxis protein CheA2.7.13.30.455
2hog710Serine/threonine-protein kinase Chk12.7.11.10.455
3s1dZIRCytokinin dehydrogenase 11.5.99.120.455
4awq592Heat shock protein HSP 90-alpha/0.455
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.454
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.454
2yi66QMHeat shock protein HSP 90-alpha/0.454
1thnADPAnti-sigma F factor/0.453
4wudANPDNA gyrase subunit B/0.453
5a9sNAPPutative dehydrogenase/0.453
3zkbANPDNA gyrase subunit B/0.452
4z1fH71Heat shock protein 75 kDa, mitochondrial/0.452
1jstATPCyclin-dependent kinase 22.7.11.220.451
2cchATPCyclin-dependent kinase 22.7.11.220.451
2pmdGNPTranslation initiation factor 2 subunit gamma/0.451
2xjgXJGHeat shock protein HSP 90-alpha/0.451
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.450
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.450
3hx4ANPCalmodulin-domain protein kinase 1/0.450
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.450
4ubtCOASteroid 3-ketoacyl-CoA thiolase/0.450
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.449
2wi2ZZ3Heat shock protein HSP 90-alpha/0.449
1finATPCyclin-dependent kinase 22.7.11.220.448
1pd9CO4Dihydrofolate reductase1.5.1.30.448
3fr4F8AFatty acid-binding protein, adipocyte/0.448
1hdrNADDihydropteridine reductase1.5.1.340.447
1kl2FONSerine hydroxymethyltransferase/0.447
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.447
1cjkFOKAdenylate cyclase type 2/0.446
1cjkFOKAdenylate cyclase type 5/0.446
1h1s4SPCyclin-dependent kinase 22.7.11.220.446
1rx1NAPDihydrofolate reductase1.5.1.30.446
2hkjRDCType 2 DNA topoisomerase 6 subunit B/0.446
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.446
4fcq2N6Heat shock protein HSP 90-alpha/0.446
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.445
4gk4L90Ephrin type-A receptor 32.7.10.10.445
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.445
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.444
2qo9ANPEphrin type-A receptor 32.7.10.10.444
2uxoTACHTH-type transcriptional regulator TtgR/0.444
3bhtMFRCyclin-dependent kinase 22.7.11.220.444
3lqfNADGalactitol dehydrogenase/0.444
4c9pCAMCytochrome P450/0.444
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.444
4wucANPDNA gyrase subunit B/0.444
5eccNAPDehydrofolate reductase type I/0.444
1yjqNAP2-dehydropantoate 2-reductase1.1.1.1690.443
2uzdC85Cyclin-dependent kinase 22.7.11.220.443
3bbrBHYGlutamate receptor 2/0.443
4gk3L87Ephrin type-A receptor 32.7.10.10.443
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.443
1i59ADPChemotaxis protein CheA2.7.13.30.442
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.442
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.442
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.442
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.442
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
4o71CPBBromodomain-containing protein 4/0.442
2bu9HFVIsopenicillin N synthase1.21.3.10.441
2feuCAMCamphor 5-monooxygenase1.14.15.10.441
2itpAEEEpidermal growth factor receptor2.7.10.10.441
2ittAEEEpidermal growth factor receptor2.7.10.10.441
2qboCAMCamphor 5-monooxygenase1.14.15.10.441
2ylxFADPhenylacetone monooxygenase1.14.13.920.441
3k6l2BBPeptide deformylase3.5.1.880.441
4l4bCAMCamphor 5-monooxygenase1.14.15.10.441
4wq4ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.441
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
1blzACVIsopenicillin N synthase1.21.3.10.440
1p0hACOMycothiol acetyltransferase2.3.1.1890.440
1sduMK1Gag-Pol polyprotein3.4.23.160.440
1vyw292Cyclin-dependent kinase 22.7.11.220.440
1z5cADPType 2 DNA topoisomerase 6 subunit B/0.440
2bxqIMNSerum albumin/0.440
2pwlACPFibroblast growth factor receptor 2/0.440
3cgdCOACoenzyme A disulfide reductase/0.440
3d75NBBPheromone-binding protein ASP1/0.440
3dmhSAMProbable ribosomal RNA small subunit methyltransferase/0.440
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.440
4g2fC07Ephrin type-A receptor 32.7.10.10.440