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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xir00JVascular endothelial growth factor receptor 22.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2xir00JVascular endothelial growth factor receptor 22.7.10.11.000
3efl706Vascular endothelial growth factor receptor 22.7.10.10.555
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.555
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.541
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.538
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.536
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.535
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.527
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.526
3hng8STVascular endothelial growth factor receptor 12.7.10.10.525
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.515
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.511
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.510
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.507
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.495
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.491
2hyySTITyrosine-protein kinase ABL12.7.10.20.479
4eyjN61Mitogen-activated protein kinase 132.7.11.240.477
1iepSTITyrosine-protein kinase ABL12.7.10.20.475
4aa0AA0Mitogen-activated protein kinase 14/0.475
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.471
3kq7KQ7Mitogen-activated protein kinase 14/0.471
3eta351Insulin receptor2.7.10.10.469
4o2z046Mitogen-activated protein kinase/0.467
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
3hv5R24Mitogen-activated protein kinase 14/0.464
3zsh469Mitogen-activated protein kinase 14/0.454
4kaoKAOFocal adhesion kinase 12.7.10.20.453
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.452
3lfbZ87Mitogen-activated protein kinase 14/0.441
3ce31FNHepatocyte growth factor receptor2.7.10.10.440