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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xikJ60Serine/threonine-protein kinase 252.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2xikJ60Serine/threonine-protein kinase 252.7.11.11.000
4qmpDKISerine/threonine-protein kinase 242.7.11.10.575
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.533
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.532
4e4m0NHTyrosine-protein kinase JAK2/0.523
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.515
3a7jADPSerine/threonine-protein kinase 242.7.11.10.511
1u4dDBQActivated CDC42 kinase 1/0.509
2x1nX1NCyclin-dependent kinase 22.7.11.220.505
3t8oATPRhodopsin kinase/0.502
3ggfGVDSerine/threonine-protein kinase 26/0.500
4iwd1JCHepatocyte growth factor receptor2.7.10.10.490
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.490
4qmzB49Serine/threonine-protein kinase 242.7.11.10.490
4qmlANPSerine/threonine-protein kinase 242.7.11.10.488
4g160VMCasein kinase I isoform gamma-32.7.11.10.484
2b7aIZATyrosine-protein kinase JAK2/0.482
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.482
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.480
4qnaX11Serine/threonine-protein kinase 242.7.11.10.480
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.479
1di8DTQCyclin-dependent kinase 22.7.11.220.478
1e9hINRCyclin-dependent kinase 22.7.11.220.478
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.478
4c02TAKActivin receptor type-12.7.11.300.478
2uzlC94Cyclin-dependent kinase 22.7.11.220.477
4lopSB4Mitogen-activated protein kinase 14/0.477
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.474
4dgo0JWCasein kinase II subunit alpha2.7.11.10.474
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
3zep1NXTyrosine-protein kinase JAK32.7.10.20.471
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.470
3a7hATPSerine/threonine-protein kinase 242.7.11.10.470
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.470
5e8wSTUTGF-beta receptor type-12.7.11.300.470
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
4dgnLU2Casein kinase II subunit alpha2.7.11.10.469
3gubGUBDeath-associated protein kinase 12.7.11.10.468
2c6tDT5Cyclin-dependent kinase 22.7.11.220.467
3rni21ZCyclin-dependent kinase 22.7.11.220.467
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.467
1h1r6CPCyclin-dependent kinase 22.7.11.220.466
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.466
1rw8580TGF-beta receptor type-12.7.11.300.465
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.465
4qmySTUSerine/threonine-protein kinase 242.7.11.10.464
1oi9N20Cyclin-dependent kinase 22.7.11.220.463
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.463
4gg70J8Hepatocyte growth factor receptor2.7.10.10.462
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.462
3bhtMFRCyclin-dependent kinase 22.7.11.220.461
4gmy0X5Tyrosine-protein kinase JAK2/0.461
2btrU73Cyclin-dependent kinase 22.7.11.220.460
3gxlQIGTGF-beta receptor type-12.7.11.300.460
4anmWULCasein kinase II subunit alpha2.7.11.10.460
2hog710Serine/threonine-protein kinase Chk12.7.11.10.459
3c50ADPRhodopsin kinase/0.459
4bgg844Activin receptor type-12.7.11.300.459
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
5drdATPAurora kinase A2.7.11.10.459
2dwbANPAurora kinase A2.7.11.10.458
2wotZZGTGF-beta receptor type-12.7.11.300.458
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.458
4qms1N1Serine/threonine-protein kinase 242.7.11.10.458
5dt3ATPAurora kinase A2.7.11.10.458
1h1s4SPCyclin-dependent kinase 22.7.11.220.457
1oiuN76Cyclin-dependent kinase 22.7.11.220.457
1xjdSTUProtein kinase C theta type2.7.11.130.457
1ke6LS2Cyclin-dependent kinase 22.7.11.220.456
1p4fDRGDeath-associated protein kinase 12.7.11.10.456
2iw84SPCyclin-dependent kinase 22.7.11.220.456
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.455
3rpv26ZCyclin-dependent kinase 22.7.11.220.455
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.455
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.454
3rk507ZCyclin-dependent kinase 22.7.11.220.454
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.454
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.452
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2w05FRTCyclin-dependent kinase 22.7.11.220.452
4loqSB4Mitogen-activated protein kinase 14/0.452
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.452
3ogqAB1Pol polyprotein/0.451
4ez30S0Cyclin-dependent kinase 22.7.11.220.451
1gij2PUCyclin-dependent kinase 22.7.11.220.450
2iw94SPCyclin-dependent kinase 22.7.11.220.450
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.450
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.450
1g5sI17Cyclin-dependent kinase 22.7.11.220.449
4ek610KCyclin-dependent kinase 22.7.11.220.449
1dm2HMDCyclin-dependent kinase 22.7.11.220.448
1gih1PUCyclin-dependent kinase 22.7.11.220.448
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.448
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.448
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3nynSGVG protein-coupled receptor kinase 62.7.11.160.447
3r73X87Cyclin-dependent kinase 22.7.11.220.447
4acm7YGCyclin-dependent kinase 22.7.11.220.447
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.447
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.447
2cchATPCyclin-dependent kinase 22.7.11.220.446
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.446
2vagV25Dual specificity protein kinase CLK12.7.12.10.446
3l8p0CEAngiopoietin-1 receptor2.7.10.10.446
3rk708ZCyclin-dependent kinase 22.7.11.220.446
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.446
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.446
4i22IREEpidermal growth factor receptor2.7.10.10.446
1y91CT9Cyclin-dependent kinase 22.7.11.220.445
2xmyCDKCyclin-dependent kinase 22.7.11.220.445
3a60STURibosomal protein S6 kinase beta-12.7.11.10.445
3c4zADPRhodopsin kinase/0.445
3sheI85MAP kinase-activated protein kinase 32.7.11.10.445
4erwSTUCyclin-dependent kinase 22.7.11.220.445
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.445
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.445
1oiyN41Cyclin-dependent kinase 22.7.11.220.444
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.444
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.444
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.444
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
4fkv61KCyclin-dependent kinase 22.7.11.220.444
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.444
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.444
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.444
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.444
2izrBRKCasein kinase I isoform gamma-32.7.11.10.443
2uzeC95Cyclin-dependent kinase 22.7.11.220.443
2wgjVGHHepatocyte growth factor receptor2.7.10.10.443
3c4xATPRhodopsin kinase/0.443
3ddpRC8Cyclin-dependent kinase 22.7.11.220.443
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.443
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.443
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.443
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.442
2eufLQQCyclin-dependent kinase 62.7.11.220.442
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.442
4fkr45KCyclin-dependent kinase 22.7.11.220.442
4jqeANPCasein kinase II subunit alpha2.7.11.10.442
5auuLU2Death-associated protein kinase 12.7.11.10.442
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.441
2fumMIXSerine/threonine-protein kinase PknB2.7.11.10.441
2wihP48Cyclin-dependent kinase 22.7.11.220.441
2xnbY8LCyclin-dependent kinase 22.7.11.220.441
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.441
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.441
3lfqA28Cyclin-dependent kinase 22.7.11.220.441
3ti1B49Cyclin-dependent kinase 22.7.11.220.441
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.441
4eok4SPCyclin-dependent kinase 22.7.11.220.441
4fko20KCyclin-dependent kinase 22.7.11.220.441
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.441