sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 1.000 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.657 | |
| 3eko | PYU | Heat shock protein HSP 90-alpha | / | 0.620 | |
| 4ce3 | L4V | ATP-dependent molecular chaperone HSP82 | / | 0.619 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.616 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.616 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.607 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.607 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.602 | |
| 2gqp | PA7 | Endoplasmin | / | 0.596 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.583 | |
| 1qy5 | NEC | Endoplasmin | / | 0.583 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.582 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.582 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.580 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.578 | |
| 1u0z | RDC | Endoplasmin | / | 0.575 | |
| 2gfd | RDA | Endoplasmin | / | 0.575 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.575 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.570 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.569 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.568 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.567 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.567 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.567 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.566 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.564 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.561 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.559 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.557 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.557 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.556 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.555 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.554 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.553 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.552 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.552 | |
| 1qy8 | RDI | Endoplasmin | / | 0.550 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.550 | |
| 2fyp | RDE | Endoplasmin | / | 0.548 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.548 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.547 | |
| 1ysz | NEC | Endoplasmin | / | 0.546 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.545 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.544 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.543 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.543 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.542 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.541 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.541 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.541 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.535 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.534 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.534 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.534 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.533 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.531 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.529 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.529 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.527 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.527 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.526 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.526 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.525 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.524 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.524 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.524 | |
| 1u0y | PA7 | Endoplasmin | / | 0.522 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.519 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.519 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 3ied | AN2 | HSP90 | / | 0.518 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.516 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.516 | |
| 1u2o | NEC | Endoplasmin | / | 0.515 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.514 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 2exl | GDM | Endoplasmin | / | 0.508 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.507 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.506 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.505 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.505 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.500 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.499 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.499 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.499 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.497 | |
| 4axa | RKD | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.497 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.494 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.493 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.492 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.490 | |
| 2hg1 | N5O | Endoplasmin | / | 0.490 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.489 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.489 | |
| 4b7p | 9UN | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 2esa | GDM | Endoplasmin | / | 0.487 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.486 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.485 | |
| 2xjj | L81 | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 2bu8 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.484 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.484 | |
| 2vci | 2GJ | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 2wi2 | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.482 | |
| 2yi5 | YI5 | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.482 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.481 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.481 | |
| 2wi1 | ZZ2 | Heat shock protein HSP 90-alpha | / | 0.480 | |
| 2xx5 | 13N | ATP-dependent molecular chaperone HSP82 | / | 0.479 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.478 | |
| 2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.478 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.477 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.477 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.476 | |
| 2zkj | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.476 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.474 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.474 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.474 | |
| 2hch | N5A | Endoplasmin | / | 0.472 | |
| 2p6i | SAH | Diphthine synthase | / | 0.472 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.472 | |
| 2o1u | ANP | Endoplasmin | / | 0.471 | |
| 2ye4 | 2FY | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.469 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.469 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.468 | |
| 2ayp | 43A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.467 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.467 | |
| 2uwd | 2GG | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.467 | |
| 3rlp | 3RP | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 1eio | GCH | Gastrotropin | / | 0.465 | |
| 2vo6 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.465 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 4fsn | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.464 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.464 | |
| 4j16 | NAD | NAD/NADP transhydrogenase alpha subunit 1 | / | 0.464 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1rby | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.463 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.463 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.463 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.463 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1sve | I01 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 3ft5 | MO8 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 1z59 | ADP | Type 2 DNA topoisomerase 6 subunit B | / | 0.461 | |
| 2q8i | RDC | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial | 2.7.11.2 | 0.461 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.461 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.461 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.461 | |
| 2bro | DF2 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 2cgv | 3B3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 2ic3 | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.460 | |
| 2ojf | 4PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.460 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.460 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.460 | |
| 3pej | BC2 | Endoplasmin homolog, putative | / | 0.460 | |
| 4fob | 0US | ALK tyrosine kinase receptor | 2.7.10.1 | 0.460 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.459 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 4fsw | HK6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 1xh7 | R96 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.458 | |
| 2f7e | 2EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.458 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 2e9o | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 2xjg | XJG | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 3gob | HXX | DdmC | / | 0.457 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.457 | |
| 4egh | 0OY | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.456 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.456 | |
| 3vid | 4TT | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.456 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.456 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.456 | |
| 1xh5 | R68 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.455 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2e8h | SAH | Diphthine synthase | / | 0.454 | |
| 2egl | SAH | Diphthine synthase | / | 0.454 | |
| 2owk | SAH | Diphthine synthase | / | 0.454 | |
| 2uzb | C75 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.454 | |
| 4l9q | 9TP | Serum albumin | / | 0.454 | |
| 1meu | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1snu | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.453 | |
| 2cct | 2E1 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 2hkj | RDC | Type 2 DNA topoisomerase 6 subunit B | / | 0.453 | |
| 2yec | XQ0 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.453 | |
| 3t0z | ATP | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.453 | |
| 4m11 | MXM | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.453 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 1ol6 | ATP | Aurora kinase A | 2.7.11.1 | 0.452 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.452 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 4fsm | HK1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.452 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.452 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.451 | |
| 1pkd | UCN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.451 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.451 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 1h1w | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.450 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.450 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.450 | |
| 2zdx | P4A | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.450 | |
| 3b9l | AZZ | Serum albumin | / | 0.450 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.450 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.450 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.450 | |
| 4ubt | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.450 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.449 | |
| 1nxk | STU | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.449 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.449 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.449 | |
| 3bwj | ARX | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.449 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.449 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.448 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 1g7u | PEP | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.448 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.448 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.448 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3f7z | 34O | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.448 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.448 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 4xbo | SAH | tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ | 2.1.1.200 | 0.448 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.448 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1nq5 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.447 | |
| 2egb | SAH | Diphthine synthase | / | 0.447 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.447 | |
| 2wmq | ZYQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.447 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.447 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.447 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.447 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1c6z | ROC | Protease | / | 0.446 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1ny3 | ADP | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.446 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.446 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2ijm | ADP | Focal adhesion kinase 1 | 2.7.10.2 | 0.446 | |
| 2pch | SAH | Diphthine synthase | / | 0.446 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.446 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.446 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.446 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 3uku | C69 | Actin-related protein 3 | / | 0.446 | |
| 4cki | ADN | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.446 | |
| 4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.446 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.446 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.446 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.445 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.445 | |
| 2e8r | SAH | Diphthine synthase | / | 0.445 | |
| 2xne | ASH | Aurora kinase A | 2.7.11.1 | 0.445 | |
| 2y3r | TRK | TamL | / | 0.445 | |
| 2yi7 | BZ8 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.445 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.445 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2o1v | ADP | Endoplasmin | / | 0.444 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.444 | |
| 2xvv | 9DN | Serum albumin | / | 0.444 | |
| 3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.444 | |
| 4fg7 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.444 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1nqo | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.443 | |
| 1yt0 | ADP | Endoplasmin | / | 0.443 | |
| 2f7z | 6EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2hut | SAH | Diphthine synthase | / | 0.443 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2owu | SAH | Diphthine synthase | / | 0.443 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.443 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 3ieu | GDP | GTPase Era | / | 0.443 | |
| 3kjm | 245 | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.443 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3pj8 | 404 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3she | I85 | MAP kinase-activated protein kinase 3 | 2.7.11.1 | 0.443 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4rcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.443 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.443 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.442 | |
| 1qr6 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.442 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.442 | |
| 2eld | SAH | Diphthine synthase | / | 0.442 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 2uzd | C85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.442 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.442 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.442 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.442 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.442 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.441 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.441 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.441 | |
| 2ym6 | YM6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.441 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.441 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1oec | AA2 | Fibroblast growth factor receptor 2 | / | 0.440 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.440 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2e16 | SAH | Diphthine synthase | / | 0.440 | |
| 2emr | SAH | Diphthine synthase | / | 0.440 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.440 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.440 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 2yjw | YJW | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3dnd | LL2 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.440 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 5cvc | PLP | Serine racemase | / | 0.440 |