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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.11.000
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.568
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.565
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.553
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.549
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.540
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.540
2hog710Serine/threonine-protein kinase Chk12.7.11.10.539
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.539
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.535
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.532
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.531
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.530
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.528
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.527
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.526
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.526
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.524
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.523
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.523
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.518
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.516
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.515
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.514
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.514
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.513
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.511
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.510
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.509
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.509
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.509
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.508
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.508
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.507
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.507
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.506
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.506
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.504
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.503
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.503
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.503
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.502
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.498
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.497
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.497
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.497
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.497
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.496
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.496
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.494
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.494
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.493
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.492
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.492
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.491
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.490
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.488
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.487
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.487
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.487
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.486
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.486
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.485
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.485
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.484
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.483
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.483
4fv6E57Mitogen-activated protein kinase 12.7.11.240.483
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.482
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.482
3t8oATPRhodopsin kinase/0.482
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.482
4fv9E71Mitogen-activated protein kinase 12.7.11.240.481
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.480
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.480
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.480
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.477
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.477
3i60E86Mitogen-activated protein kinase 12.7.11.240.477
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
1zrzBI1Protein kinase C iota type2.7.11.130.476
2wxvWXVCyclin-dependent kinase 22.7.11.220.475
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.475
1pjkANPCasein kinase II subunit alpha2.7.11.10.473
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.473
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.473
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.471
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.470
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.470
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.469
3a62STURibosomal protein S6 kinase beta-12.7.11.10.469
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.468
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.468
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.468
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.468
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.466
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.466
4fod0UVALK tyrosine kinase receptor2.7.10.10.465
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.464
4gmy0X5Tyrosine-protein kinase JAK2/0.464
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.464
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.463
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.463
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.462
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.462
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.462
3bhtMFRCyclin-dependent kinase 22.7.11.220.462
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.462
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.462
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.461
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.461
2ojj82AMitogen-activated protein kinase 12.7.11.240.460
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.460
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.460
1rfuADPPyridoxal kinase2.7.1.350.459
2qo7ANPEphrin type-A receptor 32.7.10.10.459
2qo9ANPEphrin type-A receptor 32.7.10.10.459
3r9uFADThioredoxin reductase/0.459
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.459
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.459
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.458
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.458
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.458
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.458
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.457
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.457
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.457
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.457
3c4xATPRhodopsin kinase/0.457
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.456
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.456
2j0lANPFocal adhesion kinase 12.7.10.20.455
4b99R4LMitogen-activated protein kinase 72.7.11.240.455
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.455
4fv8E63Mitogen-activated protein kinase 12.7.11.240.455
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.455
1xe55FEPlasmepsin-23.4.23.390.454
2j0m4STFocal adhesion kinase 12.7.10.20.453
2vd5BI8Myotonin-protein kinase2.7.11.10.453
3pxkPXKFocal adhesion kinase 12.7.10.20.453
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.453
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.453
4jia1K3Tyrosine-protein kinase JAK2/0.453
3zep1NXTyrosine-protein kinase JAK32.7.10.20.452
3zh8C58Protein kinase C iota type2.7.11.130.452
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.451
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.451
4l4eCAMCamphor 5-monooxygenase1.14.15.10.451
2c4g514Cyclin-dependent kinase 22.7.11.220.450
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.450
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.450
4l4fCAMCamphor 5-monooxygenase1.14.15.10.450
2y6o1N1Ephrin type-A receptor 42.7.10.10.449
4aguD15Cyclin-dependent kinase-like 1/0.449
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.448
2itvANPEpidermal growth factor receptor2.7.10.10.448
3l63CAMCamphor 5-monooxygenase1.14.15.10.448
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.448
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.448
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.448
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.448
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.447
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.447
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.447
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.447
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.447
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.447
4qmlANPSerine/threonine-protein kinase 242.7.11.10.447
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.447
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.446
2qoqANPEphrin type-A receptor 32.7.10.10.446
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.446
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.446
3c4zADPRhodopsin kinase/0.446
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.446
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.446
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.445
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.445
2itnANPEpidermal growth factor receptor2.7.10.10.445
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.445
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.445
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.445
2hk9NAPShikimate dehydrogenase (NADP(+))/0.444
3a7hATPSerine/threonine-protein kinase 242.7.11.10.444
3eyhIZATyrosine-protein kinase JAK1/0.444
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.444
3u9eCOALmo1369 protein/0.444
4qo9627Serine/threonine-protein kinase 242.7.11.10.444
1bwsNDPGDP-L-fucose synthase/0.443
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.443
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.443
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3tnwF18Cyclin-dependent kinase 22.7.11.220.443
4a6cQG9Gag-Pol polyprotein3.4.23.160.443
4aqc88ATyrosine-protein kinase JAK2/0.443
4gk3L87Ephrin type-A receptor 32.7.10.10.443
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.443
5dr9SKEAurora kinase A2.7.11.10.443
1o76CAMCamphor 5-monooxygenase1.14.15.10.442
1tvoFRZMitogen-activated protein kinase 12.7.11.240.442
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4a99FADTetX family tetracycline inactivation enzyme/0.442
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.442
2wipP49Cyclin-dependent kinase 22.7.11.220.441
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.441
3hk1B64Fatty acid-binding protein, adipocyte/0.441
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.441
3pvuQRWBeta-adrenergic receptor kinase 12.7.11.150.441
4fmqANPMitogen-activated protein kinase 12.7.11.240.441
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.441
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.440
2acxANPG protein-coupled receptor kinase 62.7.11.160.440
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.440
2xyuQ9GEphrin type-A receptor 42.7.10.10.440
3zuyTCHTransporter/0.440
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.440