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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2x8hFADThioredoxin glutathione reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2x8hFADThioredoxin glutathione reductase/1.000
2x8gFADThioredoxin glutathione reductase/0.761
1dncFADGlutathione reductase, mitochondrial1.8.1.70.515
4la1FADThioredoxin glutathione reductase/0.499
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.472
4b1bFADThioredoxin reductase1.8.1.90.466
2jk6FADTrypanothione reductase/0.449
2tprFADTrypanothione reductase1.8.1.120.442
4dnaFADProbable glutathione reductase/0.440