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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2x7gPVBSRSF protein kinase 22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2x7gPVBSRSF protein kinase 22.7.11.11.000
3begANPSRSF protein kinase 12.7.11.10.547
1wbpADPSRSF protein kinase 12.7.11.10.514
2zjwREFCasein kinase II subunit alpha2.7.11.10.452
4bcqTJFCyclin-dependent kinase 22.7.11.220.449
3le62BZCyclin-dependent kinase 22.7.11.220.444
5cvhADPCasein kinase II subunit alpha2.7.11.10.444
4grb0XGCasein kinase II subunit alpha2.7.11.10.441