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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.11.000
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.553
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.527
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.525
4hge15VTyrosine-protein kinase JAK2/0.518
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.517
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.516
4dgmAGICasein kinase II subunit alpha2.7.11.10.515
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.514
2pvhP19Casein kinase II subunit alpha2.7.11.10.511
2pvmP29Casein kinase II subunit alpha2.7.11.10.511
3w33W19Epidermal growth factor receptor2.7.10.10.510
4j98ACPFibroblast growth factor receptor 2/0.510
4jia1K3Tyrosine-protein kinase JAK2/0.510
2v7a627Tyrosine-protein kinase ABL12.7.10.20.509
3nynSGVG protein-coupled receptor kinase 62.7.11.160.509
5e8ySTUTGF-beta receptor type-22.7.11.300.508
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.504
4jajXU1Aurora kinase A2.7.11.10.504
2wouZZFTGF-beta receptor type-12.7.11.300.500
4f081RSTyrosine-protein kinase JAK2/0.500
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.499
4dgnLU2Casein kinase II subunit alpha2.7.11.10.499
4hvi19STyrosine-protein kinase JAK32.7.10.20.498
1om1IQACasein kinase II subunit alpha2.7.11.10.497
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.497
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.497
4y93746Tyrosine-protein kinase/0.496
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.495
4jboWPHAurora kinase A2.7.11.10.495
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.493
3w2sW2REpidermal growth factor receptor2.7.10.10.492
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.491
3kvxFMYMitogen-activated protein kinase 102.7.11.240.491
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.491
1fvv107Cyclin-dependent kinase 22.7.11.220.490
3lfqA28Cyclin-dependent kinase 22.7.11.220.490
4grb0XGCasein kinase II subunit alpha2.7.11.10.490
3hmm855TGF-beta receptor type-12.7.11.300.489
4anmWULCasein kinase II subunit alpha2.7.11.10.489
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.487
3be9P04Casein kinase II subunit alpha2.7.11.10.486
3ezvEZVCyclin-dependent kinase 22.7.11.220.486
3u4uLNHCasein kinase II subunit alpha2.7.11.10.485
3ttiKBIMitogen-activated protein kinase 102.7.11.240.484
4aqc88ATyrosine-protein kinase JAK2/0.484
2w17I19Cyclin-dependent kinase 22.7.11.220.481
2pvlP55Casein kinase II subunit alpha2.7.11.10.480
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.480
1m2pHNACasein kinase II subunit alpha2.7.11.10.479
2p33J07Mitogen-activated protein kinase 102.7.11.240.479
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.479
4ez50RSCyclin-dependent kinase 62.7.11.220.478
1vjy460TGF-beta receptor type-12.7.11.300.477
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.477
2xrwANPMitogen-activated protein kinase 82.7.11.240.476
3rkb12ZCyclin-dependent kinase 22.7.11.220.476
4f650S9Fibroblast growth factor receptor 1/0.476
5dt0SKEAurora kinase A2.7.11.10.476
3r8lZ30Cyclin-dependent kinase 22.7.11.220.475
3s1h56ZCyclin-dependent kinase 22.7.11.220.475
1eh4IC1Casein kinase I homolog 12.7.11.10.474
2uzbC75Cyclin-dependent kinase 22.7.11.220.474
3r83Z14Cyclin-dependent kinase 22.7.11.220.474
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.472
3lpbNVBTyrosine-protein kinase JAK2/0.472
4nk92K5Fibroblast growth factor receptor 1/0.472
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.471
1pxmCK5Cyclin-dependent kinase 22.7.11.220.470
4dtaADNAPH(2'')-Id/0.470
5dnrATPAurora kinase A2.7.11.10.469
3gu7ADPDeath-associated protein kinase 12.7.11.10.468
3q9xEMOCasein kinase II subunit alpha2.7.11.10.468
4wsqKSAAP2-associated protein kinase 12.7.11.10.468
5dr9SKEAurora kinase A2.7.11.10.468
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.467
3rak03ZCyclin-dependent kinase 22.7.11.220.467
3sheI85MAP kinase-activated protein kinase 32.7.11.10.467
4btjADPTau-tubulin kinase 12.7.11.10.467
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.467
4j99ACPFibroblast growth factor receptor 2/0.467
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.466
4y95746Tyrosine-protein kinase/0.466
1gii1PUCyclin-dependent kinase 22.7.11.220.465
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.465
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.465
5av2KMPDeath-associated protein kinase 12.7.11.10.465
4e6d0NUTyrosine-protein kinase JAK2/0.464
4j95ACPFibroblast growth factor receptor 2/0.464
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.463
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.463
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.463
2ckeIQUDeath-associated protein kinase 2/0.462
3i60E86Mitogen-activated protein kinase 12.7.11.240.462
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.461
3zmmF9JTyrosine-protein kinase JAK2/0.461
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.461
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.461
2btsU32Cyclin-dependent kinase 22.7.11.220.460
2vu3LZECyclin-dependent kinase 22.7.11.220.460
3cgfJNFMitogen-activated protein kinase 102.7.11.240.460
3cgoJNOMitogen-activated protein kinase 102.7.11.240.460
3lfnA27Cyclin-dependent kinase 22.7.11.220.460
3nux3NVCyclin-dependent kinase 62.7.11.220.460
4deeADPAurora kinase A2.7.11.10.460
1ke5LS1Cyclin-dependent kinase 22.7.11.220.459
2a0cCK9Cyclin-dependent kinase 22.7.11.220.459
4bcmT7ZCyclin-dependent kinase 22.7.11.220.459
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
2c6lDT4Cyclin-dependent kinase 22.7.11.220.458
3qxpX64Cyclin-dependent kinase 22.7.11.220.458
4btmF8ETau-tubulin kinase 12.7.11.10.458
1oirHDYCyclin-dependent kinase 22.7.11.220.457
2pvjP44Casein kinase II subunit alpha2.7.11.10.457
2w05FRTCyclin-dependent kinase 22.7.11.220.457
3r7yZ04Cyclin-dependent kinase 22.7.11.220.457
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.457
5dpvSKEAurora kinase A2.7.11.10.457
2vv9IM9Cyclin-dependent kinase 22.7.11.220.456
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.456
4fklCK2Cyclin-dependent kinase 22.7.11.220.456
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.455
2h96893Mitogen-activated protein kinase 82.7.11.240.455
3axwTIDCasein kinase II subunit alpha2.7.11.10.455
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.455
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.454
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.454
4jqeANPCasein kinase II subunit alpha2.7.11.10.454
1dawANPCasein kinase II subunit alpha2.7.11.10.453
3gu83GUDeath-associated protein kinase 12.7.11.10.453
1w8cN69Cyclin-dependent kinase 22.7.11.220.452
3dfcANPDeath-associated protein kinase 12.7.11.10.452
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.452
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.451
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.451
3at4CCKCasein kinase II subunit alpha2.7.11.10.450
3mtfA3FActivin receptor type-12.7.11.300.450
3qqlX03Cyclin-dependent kinase 22.7.11.220.450
3zewSTUEphrin type-B receptor 42.7.10.10.450
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.449
1xjdSTUProtein kinase C theta type2.7.11.130.449
1yvj4STTyrosine-protein kinase JAK32.7.10.20.449
2c6o4SPCyclin-dependent kinase 22.7.11.220.449
2pwlACPFibroblast growth factor receptor 2/0.449
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.449
4fv6E57Mitogen-activated protein kinase 12.7.11.240.449
4k33ACPFibroblast growth factor receptor 32.7.10.10.449
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3js2VM1Fibroblast growth factor receptor 1/0.448
4i5cC5ITyrosine-protein kinase JAK1/0.448
5cvfATPCasein kinase II subunit alpha2.7.11.10.448
1pxlCK4Cyclin-dependent kinase 22.7.11.220.447
2hog710Serine/threonine-protein kinase Chk12.7.11.10.447
2pvnP63Casein kinase II subunit alpha2.7.11.10.447
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.447
3fz1B98Cyclin-dependent kinase 22.7.11.220.447
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.447
4jbpYPHAurora kinase A2.7.11.10.447
2zoq5IDMitogen-activated protein kinase 32.7.11.240.446
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.446
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.446
3qwjX6ACyclin-dependent kinase 22.7.11.220.446
4btkDTQTau-tubulin kinase 12.7.11.10.446
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
3r1yX76Cyclin-dependent kinase 22.7.11.220.445
3rahO1ZCyclin-dependent kinase 22.7.11.220.445
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.445
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.445
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.445
4ux9ANPMitogen-activated protein kinase 82.7.11.240.445
2a4lRRCCyclin-dependent kinase 22.7.11.220.444
2b7aIZATyrosine-protein kinase JAK2/0.444
2btrU73Cyclin-dependent kinase 22.7.11.220.444
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.444
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.444
4ji91M3Tyrosine-protein kinase JAK2/0.444
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
1bygSTUTyrosine-protein kinase CSK/0.443
1py5PY1TGF-beta receptor type-12.7.11.300.443
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
3gubGUBDeath-associated protein kinase 12.7.11.10.443
3my5RFZCyclin-dependent kinase 22.7.11.220.443
4ic7ANPMitogen-activated protein kinase 72.7.11.240.443
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.443
1oitHDTCyclin-dependent kinase 22.7.11.220.442
4fk60UJTyrosine-protein kinase JAK1/0.442
4kbk1QGCasein kinase I isoform delta2.7.11.10.442
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.442
2j0lANPFocal adhesion kinase 12.7.10.20.441
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.441
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.441
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1aq1STUCyclin-dependent kinase 22.7.11.220.440
1pmn984Mitogen-activated protein kinase 102.7.11.240.440
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.440
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3iok1P6Tyrosine-protein kinase JAK2/0.440
3w2rW2REpidermal growth factor receptor2.7.10.10.440
4c61LMMTyrosine-protein kinase JAK2/0.440
4g1wG1WMitogen-activated protein kinase 82.7.11.240.440
5dr6SKEAurora kinase A2.7.11.10.440