scPDB - Distribution of Cavity Similarity values of 2x06 entry / Site 8

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2x06	NAD	L-sulfolactate dehydrogenase

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
2x06	NAD	L-sulfolactate dehydrogenase	/	1.000
1vbi	NAD	Malate/L-lactate dehydrogenase family protein	/	0.492
3in6	FMN	Uncharacterized protein	/	0.481
4bfx	ZVX	Pantothenate kinase	2.7.1.33	0.481
4bft	ZVT	Pantothenate kinase	2.7.1.33	0.480
4bfv	ZVV	Pantothenate kinase	2.7.1.33	0.478
2whq	HI6	Acetylcholinesterase	3.1.1.7	0.477
1iol	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.470
1xdd	AAY	Integrin alpha-L	/	0.470
4eji	0QA	Cytochrome P450 2A13	1.14.14.1	0.470
2zsa	ADP	Pantothenate kinase	2.7.1.33	0.468
4a8v	2AN	Major pollen allergen Bet v 1-J	/	0.465
1ppj	ANY	Cytochrome b	/	0.464
2ea2	F77	Methionine aminopeptidase 2	/	0.464
3lqf	NAD	Galactitol dehydrogenase	/	0.463
4bc7	FAD	Alkyldihydroxyacetonephosphate synthase, peroxisomal	2.5.1.26	0.462
3e8x	NAP	BH1520 protein	/	0.461
3uoy	FAD	2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase	1.14.13.160	0.461
3u9f	CLM	Chloramphenicol acetyltransferase	2.3.1.28	0.460
4bfw	ZVW	Pantothenate kinase	2.7.1.33	0.460
4prx	ADP	DNA gyrase subunit B	/	0.460
4ara	C56	Acetylcholinesterase	3.1.1.7	0.459
2po7	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.457
3dys	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.457
3h3q	H13	Collagen type IV alpha-3-binding protein	/	0.457
3fhx	PLP	Pyridoxal kinase	2.7.1.35	0.456
4a87	NAR	Major pollen allergen Bet v 1-A	/	0.456
4bfz	ZVZ	Pantothenate kinase	2.7.1.33	0.456
4udq	FAD	5-(hydroxymethyl)furfural oxidase	/	0.456
2gev	COK	Pantothenate kinase	2.7.1.33	0.455
1x1d	SAH	C-20 methyltransferase	/	0.454
3h06	VBP	Glutamate receptor 2	/	0.454
1o76	CAM	Camphor 5-monooxygenase	1.14.15.1	0.453
2qw0	34Z	4-chlorobenzoyl CoA ligase	/	0.453
3jyo	NAD	Quinate/shikimate dehydrogenase (NAD(+))	/	0.453
4fxy	0W2	Neurolysin, mitochondrial	3.4.24.16	0.453
2gjl	FMN	Nitronate monooxygenase	1.13.12.16	0.452
2ggs	NDP	dTDP-4-dehydrorhamnose reductase	/	0.451
2x9d	ITC	Tetracycline repressor protein class D	/	0.451
3i0p	NAD	Malate dehydrogenase, putative	/	0.451
4hp8	NAP	2-deoxy-D-gluconate 3-dehydrogenase	/	0.451
1xe6	5FP	Plasmepsin-2	3.4.23.39	0.450
3br3	ET	HTH-type transcriptional regulator QacR	/	0.450
1ps9	MDE	2,4-dienoyl-CoA reductase	1.3.1.34	0.449
4e2d	FMN	Dehydrogenase	/	0.449
2rqf	JH3	Hemolymph juvenile hormone binding protein	/	0.448
2vig	FAD	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	1.3.8.1	0.448
3b9l	AZZ	Serum albumin	/	0.448
3jsi	WTC	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.448
1gw2	FER	Peroxidase C1A	1.11.1.7	0.447
2a58	RBF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.447
2cft	PLP	Pyridoxal phosphate phosphatase	/	0.447
3fwj	CAM	Camphor 5-monooxygenase	1.14.15.1	0.447
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.447
4g2l	0WL	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.447
2a0x	DIH	Purine nucleoside phosphorylase	2.4.2.1	0.446
2a94	AP0	L-lactate dehydrogenase	1.1.1.27	0.446
3jpu	TY4	Transcriptional activator protein LasR	/	0.446
3opx	U5P	Suppressor of disruption of TFIIS	/	0.446
2g1n	1IG	Renin	3.4.23.15	0.445
3qgf	46F	Genome polyprotein	2.7.7.48	0.445
4a81	DXC	Major pollen allergen Bet v 1-A	/	0.445
4iar	ERM	5-hydroxytryptamine receptor 1B	/	0.445
4l4f	CAM	Camphor 5-monooxygenase	1.14.15.1	0.445
1x1c	SAH	C-20 methyltransferase	/	0.444
2ed3	SAH	Diphthine synthase	/	0.444
2qd4	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.444
3t4e	NAD	Quinate/shikimate dehydrogenase	/	0.444
3tjz	GNP	ADP-ribosylation factor 1	/	0.444
1a8r	GTP	GTP cyclohydrolase 1	3.5.4.16	0.443
1a9c	GTP	GTP cyclohydrolase 1	3.5.4.16	0.443
4bfu	ZVU	Pantothenate kinase	2.7.1.33	0.443
1hdc	CBO	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	1.1.1.53	0.442
1t4c	COA	Formyl-CoA:oxalate CoA-transferase	/	0.442
1w6h	TIT	Plasmepsin-2	3.4.23.39	0.442
3dy8	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.442
3dyl	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.442
3wag	TYD	Glycosyltransferase	/	0.442
4x7z	ZM3	Mycinamicin III 3''-O-methyltransferase	2.1.1.237	0.442
2a0y	DIH	Purine nucleoside phosphorylase	2.4.2.1	0.441
2c29	NAP	Dihydroflavonol 4-reductase	/	0.441
2he5	NDP	Aldo-keto reductase family 1 member C21	1.1.1	0.441
4a83	DXC	Major pollen allergen Bet v 1-A	/	0.441
4du8	2P0	Mevalonate diphosphate decarboxylase	/	0.441
4ek1	CAM	Camphor 5-monooxygenase	1.14.15.1	0.441
4hbg	NDP	3-oxoacyl-[acyl-carrier-protein] reductase	1.1.1.100	0.441
1kbo	340	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.440
1u8v	FAD	4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase	/	0.440
2g8y	NAD	Hydroxycarboxylate dehydrogenase B	/	0.440
2geu	COK	Pantothenate kinase	2.7.1.33	0.440
2hrc	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.440
2o1s	TDP	1-deoxy-D-xylulose-5-phosphate synthase	2.2.1.7	0.440
3dva	TPW	Pyruvate dehydrogenase E1 component subunit alpha	1.2.4.1	0.440
3dva	TPW	Pyruvate dehydrogenase E1 component subunit beta	1.2.4.1	0.440
3pm1	ET	HTH-type transcriptional regulator QacR	/	0.440
3pqb	VGP	Putative oxidoreductase	/	0.440
4c7k	NAP	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.440
4z87	GDP	Inosine-5'-monophosphate dehydrogenase	/	0.440