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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wp5FADTrypanothione reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2wp5FADTrypanothione reductase/1.000
4nevFADTrypanothione reductase/0.575
2jk6FADTrypanothione reductase/0.564
1tytFADTrypanothione reductase1.8.1.120.561
1bzlFADTrypanothione reductase1.8.1.120.552
1gxfFADTrypanothione reductase1.8.1.120.551
2wbaFADTrypanothione reductase1.8.1.120.550
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.545
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.90.540
4dnaFADProbable glutathione reductase/0.539
2hqmFADGlutathione reductase1.8.1.70.521
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.516
1febFADTrypanothione reductase1.8.1.120.515
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.514
1typFADTrypanothione reductase1.8.1.120.499
1feaFADTrypanothione reductase1.8.1.120.497
4la1FADThioredoxin glutathione reductase/0.497
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.496
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.493
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.489
1grgFADGlutathione reductase, mitochondrial1.8.1.70.488
2w0hFADTrypanothione reductase/0.487
1greFADGlutathione reductase, mitochondrial1.8.1.70.486
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.485
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.485
1gerFADGlutathione reductase1.8.1.70.481
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.481
3ntaFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.474
1grhFADGlutathione reductase, mitochondrial1.8.1.70.472
2v6oFADThioredoxin glutathione reductase/0.470
4j57FADThioredoxin reductase 21.8.1.90.469
4j56FADThioredoxin reductase 21.8.1.90.468
2wowFADTrypanothione reductase/0.462
3ntdFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.459
3grsFADGlutathione reductase, mitochondrial1.8.1.70.455
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.455
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.453
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.451
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.451
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.447
1graFADGlutathione reductase, mitochondrial1.8.1.70.446
3ladFADDihydrolipoyl dehydrogenase/0.444