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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wotZZGTGF-beta receptor type-12.7.11.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2wotZZGTGF-beta receptor type-12.7.11.301.000
2wouZZFTGF-beta receptor type-12.7.11.300.624
1vjy460TGF-beta receptor type-12.7.11.300.577
5e8wSTUTGF-beta receptor type-12.7.11.300.572
1rw8580TGF-beta receptor type-12.7.11.300.536
3gxlQIGTGF-beta receptor type-12.7.11.300.534
3hmm855TGF-beta receptor type-12.7.11.300.528
1py5PY1TGF-beta receptor type-12.7.11.300.522
3mtfA3FActivin receptor type-12.7.11.300.520
4c02TAKActivin receptor type-12.7.11.300.512
1u4dDBQActivated CDC42 kinase 1/0.497
1h1r6CPCyclin-dependent kinase 22.7.11.220.494
1eh4IC1Casein kinase I homolog 12.7.11.10.493
2iw84SPCyclin-dependent kinase 22.7.11.220.493
4i22IREEpidermal growth factor receptor2.7.10.10.487
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.486
4dymIYZActivin receptor type-12.7.11.300.485
1h1s4SPCyclin-dependent kinase 22.7.11.220.484
3uzp0CKCasein kinase I isoform delta2.7.11.10.481
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.480
4eon1ROCyclin-dependent kinase 22.7.11.220.476
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.476
4erwSTUCyclin-dependent kinase 22.7.11.220.473
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.472
3s2pPMUCyclin-dependent kinase 22.7.11.220.471
3uyt0CKCasein kinase I isoform delta2.7.11.10.471
3w33W19Epidermal growth factor receptor2.7.10.10.471
2iw94SPCyclin-dependent kinase 22.7.11.220.470
3r83Z14Cyclin-dependent kinase 22.7.11.220.470
4eor4SPCyclin-dependent kinase 22.7.11.220.470
3vt7VDXVitamin D3 receptor/0.469
4fkpLS5Cyclin-dependent kinase 22.7.11.220.468
2btrU73Cyclin-dependent kinase 22.7.11.220.467
1h0w207Cyclin-dependent kinase 22.7.11.220.466
4qmpDKISerine/threonine-protein kinase 242.7.11.10.466
1bygSTUTyrosine-protein kinase CSK/0.465
1xkkFMMEpidermal growth factor receptor2.7.10.10.465
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.465
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.465
1ckpPVBCyclin-dependent kinase 22.7.11.220.464
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.464
4riyADPEpidermal growth factor receptor2.7.10.10.464
3pj8404Cyclin-dependent kinase 22.7.11.220.463
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
2btsU32Cyclin-dependent kinase 22.7.11.220.461
5e8ySTUTGF-beta receptor type-22.7.11.300.461
3oom507Activin receptor type-12.7.11.300.460
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.460
5e8xSTUTGF-beta receptor type-12.7.11.300.460
3poz03PEpidermal growth factor receptor2.7.10.10.458
3rk909ZCyclin-dependent kinase 22.7.11.220.458
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.458
3rm618ZCyclin-dependent kinase 22.7.11.220.456
1g5sI17Cyclin-dependent kinase 22.7.11.220.455
1ke7LS3Cyclin-dependent kinase 22.7.11.220.455
1oiuN76Cyclin-dependent kinase 22.7.11.220.455
2w06FRVCyclin-dependent kinase 22.7.11.220.455
3ddpRC8Cyclin-dependent kinase 22.7.11.220.455
1di8DTQCyclin-dependent kinase 22.7.11.220.454
1jpaANPEphrin type-B receptor 22.7.10.10.454
1u54ACPActivated CDC42 kinase 1/0.454
1unlRRCCyclin-dependent-like kinase 52.7.11.10.454
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.454
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.454
1v0pPVBCell division control protein 2 homolog2.7.11.220.453
3vs3VSETyrosine-protein kinase HCK2.7.10.20.453
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.453
5e92ANPTGF-beta receptor type-22.7.11.300.453
1gih1PUCyclin-dependent kinase 22.7.11.220.451
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.451
3ddqRRCCyclin-dependent kinase 22.7.11.220.451
3zh8C58Protein kinase C iota type2.7.11.130.451
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.451
1oguST8Cyclin-dependent kinase 22.7.11.220.450
1vyw292Cyclin-dependent kinase 22.7.11.220.450
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.450
2w05FRTCyclin-dependent kinase 22.7.11.220.450
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.450
4gmy0X5Tyrosine-protein kinase JAK2/0.450
1e1xNW1Cyclin-dependent kinase 22.7.11.220.449
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.449
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.449
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
2po7CHDFerrochelatase, mitochondrial4.99.1.10.447
4bcoT6QCyclin-dependent kinase 22.7.11.220.447
4bgg844Activin receptor type-12.7.11.300.447
4fv9E71Mitogen-activated protein kinase 12.7.11.240.447
2y9qANPMitogen-activated protein kinase 12.7.11.240.446
3rni21ZCyclin-dependent kinase 22.7.11.220.446
3rpo24ZCyclin-dependent kinase 22.7.11.220.446
2b52D42Cyclin-dependent kinase 22.7.11.220.445
3r1sX73Cyclin-dependent kinase 22.7.11.220.445
3r73X87Cyclin-dependent kinase 22.7.11.220.445
3vt8YI3Vitamin D3 receptor/0.445
3vt9YI4Vitamin D3 receptor/0.445
4fkg4CKCyclin-dependent kinase 22.7.11.220.445
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.444
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.444
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.444
4c61LMMTyrosine-protein kinase JAK2/0.444
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.444
1oirHDYCyclin-dependent kinase 22.7.11.220.443
2pwlACPFibroblast growth factor receptor 2/0.443
2yn8STUEphrin type-B receptor 42.7.10.10.443
3gubGUBDeath-associated protein kinase 12.7.11.10.443
3qu0X40Cyclin-dependent kinase 22.7.11.220.443
4fkj11KCyclin-dependent kinase 22.7.11.220.443
1oi9N20Cyclin-dependent kinase 22.7.11.220.442
1xjdSTUProtein kinase C theta type2.7.11.130.442
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.442
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.442
4k33ACPFibroblast growth factor receptor 32.7.10.10.442
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
3ggfGVDSerine/threonine-protein kinase 26/0.441
4ez30S0Cyclin-dependent kinase 22.7.11.220.441
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.440
2xikJ60Serine/threonine-protein kinase 252.7.11.10.440
3sqq99ZCyclin-dependent kinase 22.7.11.220.440
4gk3L87Ephrin type-A receptor 32.7.10.10.440
4hnf16WCasein kinase I isoform delta2.7.11.10.440
4qnaX11Serine/threonine-protein kinase 242.7.11.10.440
4y93746Tyrosine-protein kinase/0.440