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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.11.000
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.649
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.599
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.593
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.588
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.583
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.583
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.580
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.552
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.551
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.548
2uzbC75Cyclin-dependent kinase 22.7.11.220.547
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.536
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.535
4fv6E57Mitogen-activated protein kinase 12.7.11.240.535
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.532
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.532
2hog710Serine/threonine-protein kinase Chk12.7.11.10.527
3bqr4RBDeath-associated protein kinase 3/0.518
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.518
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.516
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.515
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.510
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.509
4bcmT7ZCyclin-dependent kinase 22.7.11.220.507
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.507
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.505
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.504
5av2KMPDeath-associated protein kinase 12.7.11.10.504
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.503
4o0wADNAurora kinase A2.7.11.10.503
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.502
3bu5ATPInsulin receptor2.7.10.10.501
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.501
3i60E86Mitogen-activated protein kinase 12.7.11.240.501
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.501
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.501
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.500
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.500
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.499
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
3gu7ADPDeath-associated protein kinase 12.7.11.10.498
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.497
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.496
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.496
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.495
4l9i8PRRhodopsin kinase/0.495
1pjkANPCasein kinase II subunit alpha2.7.11.10.494
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.494
5dt0SKEAurora kinase A2.7.11.10.494
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.493
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.493
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.492
4fv9E71Mitogen-activated protein kinase 12.7.11.240.491
4ji91M3Tyrosine-protein kinase JAK2/0.491
5dpvSKEAurora kinase A2.7.11.10.491
3js2VM1Fibroblast growth factor receptor 1/0.490
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.489
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.488
4btjATPTau-tubulin kinase 12.7.11.10.488
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.487
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
1jklANPDeath-associated protein kinase 12.7.11.10.486
3my5RFZCyclin-dependent kinase 22.7.11.220.486
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.486
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.485
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.485
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.485
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.485
4f081RSTyrosine-protein kinase JAK2/0.484
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.484
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.484
1fvv107Cyclin-dependent kinase 22.7.11.220.483
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.483
2ckeIQUDeath-associated protein kinase 2/0.483
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.483
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.481
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.481
3gu83GUDeath-associated protein kinase 12.7.11.10.481
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.481
3nynSGVG protein-coupled receptor kinase 62.7.11.160.481
4eooATPCyclin-dependent kinase 22.7.11.220.481
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.480
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.480
3a62STURibosomal protein S6 kinase beta-12.7.11.10.479
3nux3NVCyclin-dependent kinase 62.7.11.220.479
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.478
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.478
4hvi19STyrosine-protein kinase JAK32.7.10.20.478
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.477
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.477
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.477
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.476
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.476
3zewSTUEphrin type-B receptor 42.7.10.10.476
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.476
4qnyANPMitogen activated protein kinase, putative/0.476
2j0lANPFocal adhesion kinase 12.7.10.20.475
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.475
2w05FRTCyclin-dependent kinase 22.7.11.220.474
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.474
4e6d0NUTyrosine-protein kinase JAK2/0.474
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.473
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.473
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.473
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.473
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.473
4aguD15Cyclin-dependent kinase-like 1/0.473
4hge15VTyrosine-protein kinase JAK2/0.473
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.472
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.472
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.472
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.472
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.472
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.472
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.472
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.472
4ehzJAKTyrosine-protein kinase JAK1/0.472
4fk60UJTyrosine-protein kinase JAK1/0.472
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.472
4jia1K3Tyrosine-protein kinase JAK2/0.472
4ysjADPCalmodulin-like domain protein kinase/0.472
2vv9IM9Cyclin-dependent kinase 22.7.11.220.471
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.471
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.471
4i5cC5ITyrosine-protein kinase JAK1/0.471
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.470
2x9fX9FEphrin type-B receptor 42.7.10.10.469
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.469
3ztxZTXAurora kinase B-A2.7.11.10.469
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.469
5av3KMPDeath-associated protein kinase 12.7.11.10.469
5dr9SKEAurora kinase A2.7.11.10.469
2yaaATPDeath-associated protein kinase 2/0.468
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.467
2ijmADPFocal adhesion kinase 12.7.10.20.467
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.467
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.467
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
4grb0XGCasein kinase II subunit alpha2.7.11.10.467
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.467
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.466
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.466
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.466
4aqc88ATyrosine-protein kinase JAK2/0.466
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.466
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.465
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.465
2vu3LZECyclin-dependent kinase 22.7.11.220.465
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.465
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.465
4fuxE75Mitogen-activated protein kinase 12.7.11.240.464
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.463
2pvlP55Casein kinase II subunit alpha2.7.11.10.463
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.463
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.462
2uzdC85Cyclin-dependent kinase 22.7.11.220.462
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.462
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.462
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.462
4qo9627Serine/threonine-protein kinase 242.7.11.10.462
5cvfATPCasein kinase II subunit alpha2.7.11.10.462
2pvmP29Casein kinase II subunit alpha2.7.11.10.461
3eb0DRKUncharacterized protein/0.461
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.460
4btkDTQTau-tubulin kinase 12.7.11.10.460
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.460
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.458
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.458
4h3qANPMitogen-activated protein kinase 12.7.11.240.458
4ivb1J5Tyrosine-protein kinase JAK1/0.458
4jajXU1Aurora kinase A2.7.11.10.458
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.457
2j0m4STFocal adhesion kinase 12.7.10.20.457
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.457
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.457
2xvdAS6Ephrin type-B receptor 42.7.10.10.457
3lltANPProtein serine/threonine kinase-1/0.457
3lpbNVBTyrosine-protein kinase JAK2/0.457
4gt3ATPMitogen-activated protein kinase 12.7.11.240.457
4j99ACPFibroblast growth factor receptor 2/0.457
3pe2E1BCasein kinase II subunit alpha2.7.11.10.456
2ojj82AMitogen-activated protein kinase 12.7.11.240.455
3at4CCKCasein kinase II subunit alpha2.7.11.10.455
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.455
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.454
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.454
4c3pACPAurora kinase A2.7.11.10.454
4y93746Tyrosine-protein kinase/0.454
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.453
3q9xEMOCasein kinase II subunit alpha2.7.11.10.453
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.453
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.453
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2f2uM77Rho-associated protein kinase 22.7.11.10.452
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.452
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.452
4e4n0NLTyrosine-protein kinase JAK1/0.452
1jkkANPDeath-associated protein kinase 12.7.11.10.451
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.450
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.450
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.450
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.449
4b99R4LMitogen-activated protein kinase 72.7.11.240.449
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4s33ANPMitogen-activated protein kinase 12.7.11.240.449
3c4xATPRhodopsin kinase/0.448
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.448
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.448
2vrx447Aurora kinase B-A2.7.11.10.447
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.447
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.447
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2c6iDT1Cyclin-dependent kinase 22.7.11.220.446
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.446
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.446
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.446
4anmWULCasein kinase II subunit alpha2.7.11.10.446
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.445
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
5ap7SVEDual specificity protein kinase TTK2.7.12.10.445
5dosATPAurora kinase A2.7.11.10.445
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.444
3dfcANPDeath-associated protein kinase 12.7.11.10.444
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.150.444
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.444
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.444
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.444
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.444
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.444
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.443
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.443
4dgmAGICasein kinase II subunit alpha2.7.11.10.443
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.442
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.442
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.442
4c59FEFCyclin-G-associated kinase2.7.11.10.442
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.442
4g1wG1WMitogen-activated protein kinase 82.7.11.240.442
4s34ANPMitogen-activated protein kinase 12.7.11.240.442
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.441
1qmzATPCyclin-dependent kinase 22.7.11.220.441
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.441
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.441
5e8ySTUTGF-beta receptor type-22.7.11.300.441
2w1fL0FAurora kinase A2.7.11.10.440
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.440
3be9P04Casein kinase II subunit alpha2.7.11.10.440
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.440
4dt9GMPAPH(2'')-Id/0.440