scPDB - Distribution of Cavity Similarity values of 2w9h entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2w9h	TOP	Dihydrofolate reductase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
2w9h	TOP	Dihydrofolate reductase	1.5.1.3	1.000
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.567
3tqa	NDP	Dihydrofolate reductase	/	0.566
3kjs	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.564
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.556
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.551
4elf	35I	Dihydrofolate reductase	/	0.540
3nxx	NDP	Dihydrofolate reductase	1.5.1.3	0.537
1dis	BDM	Dihydrofolate reductase	1.5.1.3	0.532
3dga	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.530
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.529
3clb	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.526
3inv	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.524
3qls	NDP	Dihydrofolate reductase	1.5.1.3	0.523
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.520
2w3b	NDP	Dihydrofolate reductase	1.5.1.3	0.517
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.516
4kl9	NDP	Dihydrofolate reductase	1.5.1.3	0.515
3d84	NDP	Dihydrofolate reductase	1.5.1.3	0.514
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.512
3fl8	RAR	Dihydrofolate reductase	/	0.512
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.512
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.512
2h2q	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.511
1rx1	NAP	Dihydrofolate reductase	1.5.1.3	0.508
3hbb	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.508
1dg8	NDP	Dihydrofolate reductase	1.5.1.3	0.507
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.507
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.505
4elh	53I	Dihydrofolate reductase	/	0.504
1ao8	MTX	Dihydrofolate reductase	1.5.1.3	0.501
2qk8	MTX	Dihydrofolate reductase	/	0.499
1j3k	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.498
2cf6	NAP	Cinnamyl alcohol dehydrogenase 5	1.1.1.195	0.498
4ele	31I	Dihydrofolate reductase	/	0.498
3qlr	NDP	Dihydrofolate reductase	1.5.1.3	0.497
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.495
1u71	MXA	Dihydrofolate reductase	1.5.1.3	0.495
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.494
1dr3	TAP	Dihydrofolate reductase	1.5.1.3	0.494
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.493
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.493
4elg	52J	Dihydrofolate reductase	/	0.490
1rx7	FOL	Dihydrofolate reductase	1.5.1.3	0.489
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.488
1dr5	NAP	Dihydrofolate reductase	1.5.1.3	0.486
1drh	NAP	Dihydrofolate reductase	1.5.1.3	0.486
3dg8	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.486
4m6j	NDP	Dihydrofolate reductase	1.5.1.3	0.486
1rx8	FOL	Dihydrofolate reductase	1.5.1.3	0.484
1rx8	NAP	Dihydrofolate reductase	1.5.1.3	0.482
2cig	1DG	Dihydrofolate reductase	1.5.1.3	0.482
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.482
1ia1	NDP	Dihydrofolate reductase	1.5.1.3	0.478
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.475
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.474
1ra3	NAP	Dihydrofolate reductase	1.5.1.3	0.473
1j3j	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.472
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.471
1ai9	NDP	Dihydrofolate reductase	1.5.1.3	0.470
5ecc	NAP	Dehydrofolate reductase type I	/	0.470
3fl9	TOP	Dihydrofolate reductase	/	0.469
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.468
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.468
1dr2	TAP	Dihydrofolate reductase	1.5.1.3	0.464
5dp2	NAP	CurF	/	0.464
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.461
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.461
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.456
3ik6	HCZ	Glutamate receptor 2	/	0.455
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.452
3kjr	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.452
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.452
1dhi	MTX	Dihydrofolate reductase	1.5.1.3	0.451
2xhd	7T9	Glutamate receptor 2	/	0.450
2xw7	NDP	Dihydrofolate reductase	/	0.450
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.450
1bzf	TMQ	Dihydrofolate reductase	1.5.1.3	0.449
1xe5	5FE	Plasmepsin-2	3.4.23.39	0.449
3b70	NAP	Enoyl reductase LovC	1	0.449
1jkx	138	Phosphoribosylglycinamide formyltransferase	/	0.448
2y0m	ACO	Histone acetyltransferase KAT8	/	0.448
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.447
1m78	NDP	Dihydrofolate reductase	1.5.1.3	0.446
1men	GAR	Trifunctional purine biosynthetic protein adenosine-3	2.1.2.2	0.446
8dfr	NDP	Dihydrofolate reductase	1.5.1.3	0.446
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.445
2d0k	FOL	Dihydrofolate reductase	1.5.1.3	0.445
2p33	J07	Mitogen-activated protein kinase 10	2.7.11.24	0.444
3gqv	NAP	Enoyl reductase LovC	1	0.443
1ppj	ANY	Cytochrome b	/	0.441