sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2w6p	OA4	Biotin carboxylase	6.3.4.14

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
2w6p	OA4	Biotin carboxylase	6.3.4.14	1.000
2w6z	L21	Biotin carboxylase	6.3.4.14	0.521
2w6n	OA2	Biotin carboxylase	6.3.4.14	0.518
2v5a	LZL	Biotin carboxylase	6.3.4.14	0.495
2v59	LZK	Biotin carboxylase	6.3.4.14	0.493
2v58	LZJ	Biotin carboxylase	6.3.4.14	0.488
3jzi	JZL	Biotin carboxylase	6.3.4.14	0.484
2w6q	OA5	Biotin carboxylase	6.3.4.14	0.483
2w6o	OA3	Biotin carboxylase	6.3.4.14	0.475
3jzf	JZK	Biotin carboxylase	6.3.4.14	0.466
2w6m	OA1	Biotin carboxylase	6.3.4.14	0.460
2w71	L23	Biotin carboxylase	6.3.4.14	0.458