sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2w3w | VG9 | Dihydrofolate reductase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2w3w | VG9 | Dihydrofolate reductase | / | 1.000 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.569 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.566 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.561 | |
| 3eek | 53S | Uncharacterized protein | / | 0.553 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.553 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.552 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.537 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 3cse | N22 | Uncharacterized protein | / | 0.527 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.520 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.519 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.517 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 3eel | 53T | Uncharacterized protein | / | 0.515 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.515 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.514 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.511 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.509 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.509 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.508 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.507 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.506 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.505 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.498 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.498 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.494 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.494 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.489 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.487 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.485 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.485 | |
| 1v79 | FR7 | Adenosine deaminase | 3.5.4.4 | 0.484 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.484 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.483 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.483 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.483 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.482 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.481 | |
| 1fml | RTL | Retinol dehydratase | / | 0.480 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.480 | |
| 2cjp | VPR | Epoxide hydrolase | / | 0.479 | |
| 3eem | 53V | Uncharacterized protein | / | 0.479 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.478 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.478 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.477 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.477 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 2bxm | IMN | Serum albumin | / | 0.476 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.476 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.476 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.474 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.473 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.473 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 2k62 | ITL | Fatty acid-binding protein, liver | / | 0.472 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.471 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.471 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.470 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.470 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.470 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.470 | |
| 1lud | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.469 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 2xvv | 9DN | Serum albumin | / | 0.468 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.468 | |
| 2pk3 | GDD | GDP-6-deoxy-D-mannose reductase | / | 0.467 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3qly | 55V | Uncharacterized protein | / | 0.467 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.465 | |
| 2bxq | IMN | Serum albumin | / | 0.465 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.465 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.465 | |
| 1nq2 | 4HY | Thyroid hormone receptor beta | / | 0.464 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.463 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.463 | |
| 2wgj | VGH | Hepatocyte growth factor receptor | 2.7.10.1 | 0.463 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.462 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.462 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.462 | |
| 3mtl | FEF | Cyclin-dependent kinase 16 | 2.7.11.22 | 0.462 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.462 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.462 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.461 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.461 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.461 | |
| 3b9l | AZZ | Serum albumin | / | 0.461 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.461 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.461 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 1osv | CHC | Bile acid receptor | / | 0.460 | |
| 1vce | SAH | Diphthine synthase | / | 0.460 | |
| 2bra | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.460 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.460 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.460 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.460 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.459 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.459 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.459 | |
| 3tij | URI | Nucleoside permease | / | 0.459 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.459 | |
| 4ie0 | PD2 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.459 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.458 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.458 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.458 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.458 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.458 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4je5 | PLP | Aromatic/aminoadipate aminotransferase 1 | 2.6.1.39 | 0.458 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.457 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.457 | |
| 4gg5 | 0J3 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.457 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.457 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.456 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.456 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.456 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4olf | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.456 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.455 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.455 | |
| 3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.455 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.455 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.455 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.454 | |
| 2vnk | FAD | NADPH:ferredoxin reductase | / | 0.454 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.454 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.454 | |
| 3wag | TYD | Glycosyltransferase | / | 0.454 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.454 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.454 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.453 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.453 | |
| 1zz2 | B11 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.453 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.453 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.453 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.453 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.453 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.453 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.453 | |
| 4mq2 | 2C4 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.453 | |
| 4zs2 | FLU | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.453 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1gvv | 0GM | Endothiapepsin | 3.4.23.22 | 0.452 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.452 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.452 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.452 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.452 | |
| 3d57 | 4HY | Thyroid hormone receptor beta | / | 0.452 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 3eej | 53R | Uncharacterized protein | / | 0.452 | |
| 3zsi | 52P | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.452 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4qkn | JMS | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.452 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.451 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.451 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.451 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.451 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.451 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.451 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.451 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1owo | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.450 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.450 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2c3u | 2TP | Pyruvate synthase | / | 0.450 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.450 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.450 | |
| 4v12 | POG | MaoC like domain protein | / | 0.450 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.449 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.449 | |
| 2pml | ANP | Uncharacterized protein | / | 0.449 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.449 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.449 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.449 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.449 | |
| 4pda | CTN | Nucleoside permease | / | 0.449 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.449 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.448 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
| 2el0 | SAH | Diphthine synthase | / | 0.448 | |
| 3cge | COA | Coenzyme A disulfide reductase | / | 0.448 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.448 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3kdu | NKS | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.448 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.448 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.448 | |
| 4b72 | 2FB | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.448 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.448 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.448 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.447 | |
| 2a8x | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.447 | |
| 2ohv | NHL | Glutamate racemase | / | 0.447 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.447 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.447 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.447 | |
| 3o3p | GDD | Glycosyl transferase, family 2 | / | 0.447 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3wtk | TH4 | Acetylcholine-binding protein | / | 0.447 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.447 | |
| 3zux | TCH | Transporter | / | 0.447 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.447 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.447 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.447 | |
| 4l4x | NDP | AmphI | / | 0.447 | |
| 4o95 | 245 | Cytokinin dehydrogenase 4 | / | 0.447 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.447 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.446 | |
| 1lgt | BP3 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.446 | |
| 1r0e | DFN | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.446 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.446 | |
| 2ejz | SAH | Diphthine synthase | / | 0.446 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.446 | |
| 2fto | TMP | Thymidylate synthase | / | 0.446 | |
| 2gtn | LIE | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.446 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.446 | |
| 4djw | 0KP | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.446 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.446 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.446 | |
| 4mr6 | 1K0 | Bromodomain-containing protein 2 | / | 0.446 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.445 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3ey9 | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.445 | |
| 3l5b | BDO | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3l5d | BDV | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.445 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.445 | |
| 3t1a | 5MA | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.445 | |
| 3wxy | COA | Uncharacterized protein | / | 0.445 | |
| 3zy6 | GFB | GDP-fucose protein O-fucosyltransferase 1 | 2.4.1.221 | 0.445 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.445 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.445 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2w6m | OA1 | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.444 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.444 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.444 | |
| 4q5j | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.444 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.444 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1owp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.443 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.443 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.443 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.443 | |
| 1xdi | FAD | NAD(P)H dehydrogenase (quinone) | / | 0.443 | |
| 2fhk | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.443 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.443 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2wkm | PFY | Hepatocyte growth factor receptor | 2.7.10.1 | 0.443 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.443 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.443 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 4djx | 0KQ | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.443 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.443 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.443 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.443 | |
| 1cbs | REA | Cellular retinoic acid-binding protein 2 | / | 0.442 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.442 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.442 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.442 | |
| 2d81 | RB3 | Poly(3-hydroxybutyrate) depolymerase | / | 0.442 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.442 | |
| 3i6i | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.442 | |
| 3jzf | JZK | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.442 | |
| 3r3c | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.442 | |
| 3zuy | TCH | Transporter | / | 0.442 | |
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 | 0.442 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4eqr | FAD | Coenzyme A disulfide reductase | / | 0.442 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.442 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.441 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.441 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.441 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.441 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.441 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.441 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.441 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.441 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.441 | |
| 4b78 | KGG | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.441 | |
| 4qjc | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.441 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.441 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.441 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.440 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.440 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.440 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2i1v | ADP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.440 | |
| 2izf | BTN | Streptavidin | / | 0.440 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.440 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2rg5 | 279 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.440 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3kjm | 245 | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.440 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.440 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.440 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.440 | |
| 4ie5 | MD6 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.440 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.440 | |
| 4j0s | 1H3 | Bromodomain-containing protein 4 | / | 0.440 | |
| 4py6 | R78 | Bromodomain protein, putative | / | 0.440 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 |