Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2w0jZATSerine/threonine-protein kinase Chk22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2w0jZATSerine/threonine-protein kinase Chk22.7.11.11.000
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.651
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.639
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.631
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.629
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.627
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.625
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.624
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.609
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.583
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.556
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.539
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.535
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.521
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.515
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.512
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.506
4jbpYPHAurora kinase A2.7.11.10.501
4jboWPHAurora kinase A2.7.11.10.497
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.496
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.484
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.483
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.483
4fv9E71Mitogen-activated protein kinase 12.7.11.240.481
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.480
1jklANPDeath-associated protein kinase 12.7.11.10.479
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.477
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.475
3hx4ANPCalmodulin-domain protein kinase 1/0.470
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.469
5av2KMPDeath-associated protein kinase 12.7.11.10.469
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.468
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.465
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.462
2c6eHPMAurora kinase A2.7.11.10.462
4wsqKSAAP2-associated protein kinase 12.7.11.10.462
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.461
4o0uADNAurora kinase A2.7.11.10.461
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
2vrx447Aurora kinase B-A2.7.11.10.458
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.458
4id71G0Activated CDC42 kinase 1/0.458
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.457
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.454
3bqr4RBDeath-associated protein kinase 3/0.453
4jia1K3Tyrosine-protein kinase JAK2/0.453
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.452
1jkkANPDeath-associated protein kinase 12.7.11.10.451
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
3ztxZTXAurora kinase B-A2.7.11.10.450
4jbqVX6Aurora kinase A2.7.11.10.449
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.449
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.449
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.448
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.447
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.447
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.447
2yaaATPDeath-associated protein kinase 2/0.445
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.445
2w05FRTCyclin-dependent kinase 22.7.11.220.444
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.444
3bu5ATPInsulin receptor2.7.10.10.444
3k5uPFQAurora kinase A2.7.11.10.444
4ysjADPCalmodulin-like domain protein kinase/0.443
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.442
3w2sW2REpidermal growth factor receptor2.7.10.10.442
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.442
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.441
4b99R4LMitogen-activated protein kinase 72.7.11.240.441
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.440
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.440
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440