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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vtjLZ4Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2vtjLZ4Cyclin-dependent kinase 22.7.11.221.000
1ke5LS1Cyclin-dependent kinase 22.7.11.220.728
2vthLZ2Cyclin-dependent kinase 22.7.11.220.674
1ke7LS3Cyclin-dependent kinase 22.7.11.220.653
1ke6LS2Cyclin-dependent kinase 22.7.11.220.627
4ek610KCyclin-dependent kinase 22.7.11.220.616
1ykr628Cyclin-dependent kinase 22.7.11.220.613
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.607
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.597
3r1yX76Cyclin-dependent kinase 22.7.11.220.597
4fkt48KCyclin-dependent kinase 22.7.11.220.596
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.594
2xmyCDKCyclin-dependent kinase 22.7.11.220.583
1oitHDTCyclin-dependent kinase 22.7.11.220.582
2btrU73Cyclin-dependent kinase 22.7.11.220.581
1w0xOLOCyclin-dependent kinase 22.7.11.220.580
4fkq42KCyclin-dependent kinase 22.7.11.220.580
3rak03ZCyclin-dependent kinase 22.7.11.220.578
1ke9LS5Cyclin-dependent kinase 22.7.11.220.573
3r8lZ30Cyclin-dependent kinase 22.7.11.220.572
3s1h56ZCyclin-dependent kinase 22.7.11.220.572
1pxmCK5Cyclin-dependent kinase 22.7.11.220.570
3qtxX43Cyclin-dependent kinase 22.7.11.220.568
3qzgX67Cyclin-dependent kinase 22.7.11.220.568
3sw418KCyclin-dependent kinase 22.7.11.220.568
3rk708ZCyclin-dependent kinase 22.7.11.220.566
2w06FRVCyclin-dependent kinase 22.7.11.220.564
4fki09KCyclin-dependent kinase 22.7.11.220.564
2a0cCK9Cyclin-dependent kinase 22.7.11.220.563
2uzoC62Cyclin-dependent kinase 22.7.11.220.563
4ek816KCyclin-dependent kinase 22.7.11.220.563
3ezvEZVCyclin-dependent kinase 22.7.11.220.561
1pxlCK4Cyclin-dependent kinase 22.7.11.220.558
3rpv26ZCyclin-dependent kinase 22.7.11.220.557
4fks46KCyclin-dependent kinase 22.7.11.220.556
1y91CT9Cyclin-dependent kinase 22.7.11.220.555
4fkpLS5Cyclin-dependent kinase 22.7.11.220.555
4fkr45KCyclin-dependent kinase 22.7.11.220.555
2c6iDT1Cyclin-dependent kinase 22.7.11.220.554
3fz1B98Cyclin-dependent kinase 22.7.11.220.554
2c6o4SPCyclin-dependent kinase 22.7.11.220.553
1gii1PUCyclin-dependent kinase 22.7.11.220.551
2r3lSCWCyclin-dependent kinase 22.7.11.220.551
4fkv61KCyclin-dependent kinase 22.7.11.220.551
1pxpCK8Cyclin-dependent kinase 22.7.11.220.550
1di8DTQCyclin-dependent kinase 22.7.11.220.549
4fko20KCyclin-dependent kinase 22.7.11.220.549
1gih1PUCyclin-dependent kinase 22.7.11.220.548
3qxoX65Cyclin-dependent kinase 22.7.11.220.548
3r1sX73Cyclin-dependent kinase 22.7.11.220.548
3rkb12ZCyclin-dependent kinase 22.7.11.220.548
2r3p3SCCyclin-dependent kinase 22.7.11.220.547
4fkg4CKCyclin-dependent kinase 22.7.11.220.547
3sw719KCyclin-dependent kinase 22.7.11.220.546
1g5sI17Cyclin-dependent kinase 22.7.11.220.545
4acm7YGCyclin-dependent kinase 22.7.11.220.545
3s2pPMUCyclin-dependent kinase 22.7.11.220.544
2vv9IM9Cyclin-dependent kinase 22.7.11.220.543
3qxpX64Cyclin-dependent kinase 22.7.11.220.543
3wblPDYCyclin-dependent kinase 22.7.11.220.543
2w17I19Cyclin-dependent kinase 22.7.11.220.542
3lfnA27Cyclin-dependent kinase 22.7.11.220.542
3r7uX96Cyclin-dependent kinase 22.7.11.220.541
2b53D23Cyclin-dependent kinase 22.7.11.220.539
2uznC96Cyclin-dependent kinase 22.7.11.220.538
1urwI1PCyclin-dependent kinase 22.7.11.220.537
3ral04ZCyclin-dependent kinase 22.7.11.220.536
3rni21ZCyclin-dependent kinase 22.7.11.220.536
1pxoCK7Cyclin-dependent kinase 22.7.11.220.535
2vu3LZECyclin-dependent kinase 22.7.11.220.535
3iggEFQCyclin-dependent kinase 22.7.11.220.534
3qzhX69Cyclin-dependent kinase 22.7.11.220.534
3rpy27ZCyclin-dependent kinase 22.7.11.220.534
2r3iSCFCyclin-dependent kinase 22.7.11.220.533
3rm719ZCyclin-dependent kinase 22.7.11.220.533
2btsU32Cyclin-dependent kinase 22.7.11.220.532
3rmf20ZCyclin-dependent kinase 22.7.11.220.531
1oirHDYCyclin-dependent kinase 22.7.11.220.529
2r3jSCJCyclin-dependent kinase 22.7.11.220.529
2r3mSCXCyclin-dependent kinase 22.7.11.220.528
3r73X87Cyclin-dependent kinase 22.7.11.220.528
3sqq99ZCyclin-dependent kinase 22.7.11.220.527
3rk909ZCyclin-dependent kinase 22.7.11.220.526
1w8cN69Cyclin-dependent kinase 22.7.11.220.525
3lfqA28Cyclin-dependent kinase 22.7.11.220.525
1p2a5BNCyclin-dependent kinase 22.7.11.220.524
3r9hZ67Cyclin-dependent kinase 22.7.11.220.524
3rk507ZCyclin-dependent kinase 22.7.11.220.524
1vyzN5BCyclin-dependent kinase 22.7.11.220.523
2w1hL0FCyclin-dependent kinase 22.7.11.220.522
4fkj11KCyclin-dependent kinase 22.7.11.220.522
1h1s4SPCyclin-dependent kinase 22.7.11.220.521
1ke8LS4Cyclin-dependent kinase 22.7.11.220.520
3roy22ZCyclin-dependent kinase 22.7.11.220.520
2r3kSCQCyclin-dependent kinase 22.7.11.220.519
2vtsLZCCyclin-dependent kinase 22.7.11.220.519
3qtuX44Cyclin-dependent kinase 22.7.11.220.519
3rpo24ZCyclin-dependent kinase 22.7.11.220.519
1pyePM1Cyclin-dependent kinase 22.7.11.220.518
2b52D42Cyclin-dependent kinase 22.7.11.220.518
3qqfX07Cyclin-dependent kinase 22.7.11.220.517
3unk0BYCyclin-dependent kinase 22.7.11.220.517
1fvv107Cyclin-dependent kinase 22.7.11.220.516
2a4lRRCCyclin-dependent kinase 22.7.11.220.516
2r64740Cyclin-dependent kinase 22.7.11.220.514
2bheBRYCyclin-dependent kinase 22.7.11.220.513
3le62BZCyclin-dependent kinase 22.7.11.220.513
4fkw62KCyclin-dependent kinase 22.7.11.220.513
3qqlX03Cyclin-dependent kinase 22.7.11.220.512
3r83Z14Cyclin-dependent kinase 22.7.11.220.512
2vttLZDCyclin-dependent kinase 22.7.11.220.511
3nynSGVG protein-coupled receptor kinase 62.7.11.160.511
3qu0X40Cyclin-dependent kinase 22.7.11.220.511
3r7yZ04Cyclin-dependent kinase 22.7.11.220.511
1oguST8Cyclin-dependent kinase 22.7.11.220.510
3ti1B49Cyclin-dependent kinase 22.7.11.220.510
1pxkCK3Cyclin-dependent kinase 22.7.11.220.508
3ddqRRCCyclin-dependent kinase 22.7.11.220.508
3qqhX0ACyclin-dependent kinase 22.7.11.220.507
3r28XA0Cyclin-dependent kinase 22.7.11.220.507
3rjc06ZCyclin-dependent kinase 22.7.11.220.507
3r7vZ02Cyclin-dependent kinase 22.7.11.220.506
1h0w207Cyclin-dependent kinase 22.7.11.220.505
1oiyN41Cyclin-dependent kinase 22.7.11.220.505
2fvdLIACyclin-dependent kinase 22.7.11.220.505
3lfsA07Cyclin-dependent kinase 22.7.11.220.505
3qtzX42Cyclin-dependent kinase 22.7.11.220.505
3unj0BXCyclin-dependent kinase 22.7.11.220.505
3py0SU9Cyclin-dependent kinase 22.7.11.220.504
4bcmT7ZCyclin-dependent kinase 22.7.11.220.503
4fklCK2Cyclin-dependent kinase 22.7.11.220.503
1aq1STUCyclin-dependent kinase 22.7.11.220.502
1y8yCT7Cyclin-dependent kinase 22.7.11.220.502
2j9mPY8Cyclin-dependent kinase 22.7.11.220.501
4ez30S0Cyclin-dependent kinase 22.7.11.220.500
3r7eX88Cyclin-dependent kinase 22.7.11.220.499
3r8vZ62Cyclin-dependent kinase 22.7.11.220.499
3pxyJWSCyclin-dependent kinase 22.7.11.220.498
3r7iX9ICyclin-dependent kinase 22.7.11.220.498
3ddpRC8Cyclin-dependent kinase 22.7.11.220.497
3qwjX6ACyclin-dependent kinase 22.7.11.220.497
4lyn1YGCyclin-dependent kinase 22.7.11.220.497
3r1qX75Cyclin-dependent kinase 22.7.11.220.496
3s0o50ZCyclin-dependent kinase 22.7.11.220.496
3tnwF18Cyclin-dependent kinase 22.7.11.220.496
2iw84SPCyclin-dependent kinase 22.7.11.220.495
3qqkX02Cyclin-dependent kinase 22.7.11.220.495
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.494
2vtrLZBCyclin-dependent kinase 22.7.11.220.494
3r9oZ71Cyclin-dependent kinase 22.7.11.220.494
1ckpPVBCyclin-dependent kinase 22.7.11.220.493
2c6lDT4Cyclin-dependent kinase 22.7.11.220.493
3ig7EFPCyclin-dependent kinase 22.7.11.220.493
3ezrEZRCyclin-dependent kinase 22.7.11.220.492
3r6xX84Cyclin-dependent kinase 22.7.11.220.492
4nj32KDCyclin-dependent kinase 22.7.11.220.492
3r8zZ63Cyclin-dependent kinase 22.7.11.220.491
1b39ATPCyclin-dependent kinase 22.7.11.220.490
2c5yMTWCyclin-dependent kinase 22.7.11.220.490
3raiX85Cyclin-dependent kinase 22.7.11.220.490
2r3o2SCCyclin-dependent kinase 22.7.11.220.489
3qtrX36Cyclin-dependent kinase 22.7.11.220.489
3r9dX6BCyclin-dependent kinase 22.7.11.220.489
1h1r6CPCyclin-dependent kinase 22.7.11.220.488
2r3r6SCCyclin-dependent kinase 22.7.11.220.488
3uli1N3Cyclin-dependent kinase 22.7.11.220.488
1fvt106Cyclin-dependent kinase 22.7.11.220.487
1v1k3FPCyclin-dependent kinase 22.7.11.220.487
2bhhRYUCyclin-dependent kinase 22.7.11.220.487
3rm618ZCyclin-dependent kinase 22.7.11.220.487
4eor4SPCyclin-dependent kinase 22.7.11.220.486
4ii5ADPCyclin-dependent kinase 22.7.11.220.486
1hckATPCyclin-dependent kinase 22.7.11.220.485
2vtqLZACyclin-dependent kinase 22.7.11.220.485
1e1xNW1Cyclin-dependent kinase 22.7.11.220.484
3be9P04Casein kinase II subunit alpha2.7.11.10.484
1dm2HMDCyclin-dependent kinase 22.7.11.220.483
4kd11QKCyclin-dependent kinase 22.7.11.220.483
4fx360KCyclin-dependent kinase 22.7.11.220.482
3bhtMFRCyclin-dependent kinase 22.7.11.220.481
4bgh3I6Cyclin-dependent kinase 22.7.11.220.480
2c6kDT2Cyclin-dependent kinase 22.7.11.220.478
2uzdC85Cyclin-dependent kinase 22.7.11.220.478
3qtqX35Cyclin-dependent kinase 22.7.11.220.478
3sheI85MAP kinase-activated protein kinase 32.7.11.10.478
1finATPCyclin-dependent kinase 22.7.11.220.477
2c6tDT5Cyclin-dependent kinase 22.7.11.220.477
3gxlQIGTGF-beta receptor type-12.7.11.300.477
3qruX19Cyclin-dependent kinase 22.7.11.220.477
3rahO1ZCyclin-dependent kinase 22.7.11.220.477
4eok4SPCyclin-dependent kinase 22.7.11.220.477
1oi9N20Cyclin-dependent kinase 22.7.11.220.476
3r71X86Cyclin-dependent kinase 22.7.11.220.476
2uzbC75Cyclin-dependent kinase 22.7.11.220.475
2wpa889Cyclin-dependent kinase 22.7.11.220.475
3my5RFZCyclin-dependent kinase 22.7.11.220.475
4btjATPTau-tubulin kinase 12.7.11.10.475
1vjy460TGF-beta receptor type-12.7.11.300.474
3ql8X01Cyclin-dependent kinase 22.7.11.220.474
1b38ATPCyclin-dependent kinase 22.7.11.220.473
4qmpDKISerine/threonine-protein kinase 242.7.11.10.473
1e9hINRCyclin-dependent kinase 22.7.11.220.472
2iw94SPCyclin-dependent kinase 22.7.11.220.472
3dogNNNCyclin-dependent kinase 22.7.11.220.472
3pj8404Cyclin-dependent kinase 22.7.11.220.471
2c69CT8Cyclin-dependent kinase 22.7.11.220.470
2r3fSC8Cyclin-dependent kinase 22.7.11.220.470
2duv371Cyclin-dependent kinase 22.7.11.220.469
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.469
2x1nX1NCyclin-dependent kinase 22.7.11.220.468
3nux3NVCyclin-dependent kinase 62.7.11.220.468
3qzfX66Cyclin-dependent kinase 22.7.11.220.468
2b54D05Cyclin-dependent kinase 22.7.11.220.467
2pvnP63Casein kinase II subunit alpha2.7.11.10.467
4aua4AUCyclin-dependent kinase 62.7.11.220.467
2exmZIPCyclin-dependent kinase 22.7.11.220.466
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.466
3i60E86Mitogen-activated protein kinase 12.7.11.240.466
1oiuN76Cyclin-dependent kinase 22.7.11.220.465
2wihP48Cyclin-dependent kinase 22.7.11.220.465
3qziX72Cyclin-dependent kinase 22.7.11.220.465
3r9nZ68Cyclin-dependent kinase 22.7.11.220.465
5e8ySTUTGF-beta receptor type-22.7.11.300.465
2r3gSC9Cyclin-dependent kinase 22.7.11.220.464
3qx2X63Cyclin-dependent kinase 22.7.11.220.464
3r8pZ46Cyclin-dependent kinase 22.7.11.220.463
2eufLQQCyclin-dependent kinase 62.7.11.220.462
3gubGUBDeath-associated protein kinase 12.7.11.10.462
4eooATPCyclin-dependent kinase 22.7.11.220.462
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.461
1eh4IC1Casein kinase I homolog 12.7.11.10.460
1vyw292Cyclin-dependent kinase 22.7.11.220.460
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.460
2uzlC94Cyclin-dependent kinase 22.7.11.220.460
2wxvWXVCyclin-dependent kinase 22.7.11.220.460
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.460
2c5nCK8Cyclin-dependent kinase 22.7.11.220.458
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.458
3qrtX14Cyclin-dependent kinase 22.7.11.220.458
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.458
1pkdUCNCyclin-dependent kinase 22.7.11.220.457
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.457
1r78FMDCyclin-dependent kinase 22.7.11.220.456
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.456
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.456
4fv6E57Mitogen-activated protein kinase 12.7.11.240.456
4qmlANPSerine/threonine-protein kinase 242.7.11.10.456
2r3q5SCCyclin-dependent kinase 22.7.11.220.455
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.455
4ez50RSCyclin-dependent kinase 62.7.11.220.455
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.455
1gij2PUCyclin-dependent kinase 22.7.11.220.454
3r8uZ31Cyclin-dependent kinase 22.7.11.220.454
2uzeC95Cyclin-dependent kinase 22.7.11.220.453
2xnbY8LCyclin-dependent kinase 22.7.11.220.453
4bcoT6QCyclin-dependent kinase 22.7.11.220.453
1qmzATPCyclin-dependent kinase 22.7.11.220.452
2b55D31Cyclin-dependent kinase 22.7.11.220.452
4eomATPCyclin-dependent kinase 22.7.11.220.452
1unlRRCCyclin-dependent-like kinase 52.7.11.10.451
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.451
1m2pHNACasein kinase II subunit alpha2.7.11.10.450
2cchATPCyclin-dependent kinase 22.7.11.220.450
3tiz3TICyclin-dependent kinase 22.7.11.220.450
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.450
4bcpT3CCyclin-dependent kinase 22.7.11.220.450
4ivb1J5Tyrosine-protein kinase JAK1/0.450
1om1IQACasein kinase II subunit alpha2.7.11.10.449
2wouZZFTGF-beta receptor type-12.7.11.300.449
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.449
1oiqHDUCyclin-dependent kinase 22.7.11.220.448
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.448
3qwkX62Cyclin-dependent kinase 22.7.11.220.448
3rzb02ZCyclin-dependent kinase 22.7.11.220.448
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.447
4bcnT9NCyclin-dependent kinase 22.7.11.220.447
3ggfGVDSerine/threonine-protein kinase 26/0.446
4bgg844Activin receptor type-12.7.11.300.446
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.446
5aniES4Cyclin-dependent kinase 22.7.11.220.446
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.444
4dgmAGICasein kinase II subunit alpha2.7.11.10.444
2c4g514Cyclin-dependent kinase 22.7.11.220.443
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3s00Z60Cyclin-dependent kinase 22.7.11.220.443
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.443
4i3zADPCyclin-dependent kinase 22.7.11.220.443
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.442
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.442
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.442
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.442
2ds11CDCyclin-dependent kinase 22.7.11.220.441
4anmWULCasein kinase II subunit alpha2.7.11.10.441
4aqc88ATyrosine-protein kinase JAK2/0.441
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.440
2hog710Serine/threonine-protein kinase Chk12.7.11.10.440
2i40BLZCyclin-dependent kinase 22.7.11.220.440
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.440
3lltANPProtein serine/threonine kinase-1/0.440
3qtwX3ACyclin-dependent kinase 22.7.11.220.440
4dgo0JWCasein kinase II subunit alpha2.7.11.10.440
5dr6SKEAurora kinase A2.7.11.10.440