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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vt4P32Beta-1 adrenergic receptor

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2vt4P32Beta-1 adrenergic receptor/1.000
2ycyP32Beta-1 adrenergic receptor/0.613
2ycxP32Beta-1 adrenergic receptor/0.598
3zpqXF5Beta-1 adrenergic receptor/0.583
2yczI32Beta-1 adrenergic receptor/0.579
4bvnP32Beta-1 adrenergic receptor/0.573
4amiG90Beta-1 adrenergic receptor/0.573
5d5aCAUBeta-2 adrenergic receptor/0.571
5d6lCAUBeta-2 adrenergic receptor/0.570
4amjCVDBeta-1 adrenergic receptor/0.567
5a8eXTKBeta-1 adrenergic receptor/0.563
5d5bCAUBeta-2 adrenergic receptor/0.555
2rh1CAUBeta-2 adrenergic receptor/0.550
5jqhCAUBeta-2 adrenergic receptor/0.546
2y035FWBeta-1 adrenergic receptor/0.540
5f8uP32Beta-1 adrenergic receptor/0.539
2ycwCAUBeta-1 adrenergic receptor/0.537
2y0468HBeta-1 adrenergic receptor/0.526
3d4sTIMBeta-2 adrenergic receptor/0.524
2y02WHJBeta-1 adrenergic receptor/0.523
4gbrCAUBeta-2 adrenergic receptor/0.520
4iarERM5-hydroxytryptamine receptor 1B/0.519
3ny8JRZBeta-2 adrenergic receptor/0.509
3sn6P0GBeta-2 adrenergic receptor/0.474
4iaq2GM5-hydroxytryptamine receptor 1B/0.466
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455