sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2vpr	TDC	Tetracycline repressor protein class H

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
2vpr	TDC	Tetracycline repressor protein class H	/	1.000
2xpw	OTC	Tetracycline repressor protein class D	/	0.537
2trt	TAC	Tetracycline repressor protein class D	/	0.531
5fkl	TDC	Tetracycline repressor protein class D	/	0.513
4b3a	TAC	Tetracycline repressor protein class D	/	0.506
5fkm	TDC	Tetracycline repressor protein class D	/	0.500
2vke	TAC	Tetracycline repressor protein class D	/	0.488
2o7o	DXT	Tetracycline repressor protein class D	/	0.484
2xpv	MIY	Tetracycline repressor protein class D	/	0.478
2tct	CTC	Tetracycline repressor protein class D	/	0.473
2xb5	I7T	Tetracycline repressor protein class D	/	0.472
4d7m	TDC	Tetracycline repressor protein class D	/	0.471
2vkv	TDC	Tetracycline repressor protein class D	/	0.455
2xpu	TDC	Tetracycline repressor protein class D	/	0.452
2xrl	DXT	Tetracycline repressor protein class D	/	0.445
2fj1	CTC	Tetracycline repressor protein class D	/	0.440
5fko	TDC	Tetracycline repressor protein class D	/	0.440