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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vci2GJHeat shock protein HSP 90-alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2vci2GJHeat shock protein HSP 90-alpha/1.000
2wi5ZZ5Heat shock protein HSP 90-alpha/0.774
4fcq2N6Heat shock protein HSP 90-alpha/0.727
2yecXQ0Heat shock protein HSP 90-alpha/0.659
2bsmBSMHeat shock protein HSP 90-alpha/0.640
2vcj2EQHeat shock protein HSP 90-alpha/0.639
4egh0OYHeat shock protein HSP 90-alpha/0.611
2yi66QMHeat shock protein HSP 90-alpha/0.609
2ye42FYHeat shock protein HSP 90-alpha/0.600
2wi1ZZ2Heat shock protein HSP 90-alpha/0.593
2ccu2D9Heat shock protein HSP 90-alpha/0.577
2cct2E1Heat shock protein HSP 90-alpha/0.576
2uwd2GGHeat shock protein HSP 90-alpha/0.575
4eftEFTHeat shock protein HSP 90-alpha/0.537
2yjwYJWHeat shock protein HSP 90-alpha/0.536
3hyz42CHeat shock protein HSP 90-alpha/0.526
2yi7BZ8Heat shock protein HSP 90-alpha/0.521
2ye92D4Heat shock protein HSP 90-alpha/0.519
4ipeANPTNF receptor-associated protein 1/0.518
2yegXQGHeat shock protein HSP 90-alpha/0.516
1yetGDMHeat shock protein HSP 90-alpha/0.514
3ft5MO8Heat shock protein HSP 90-alpha/0.511
1yc34BCHeat shock protein HSP 90-alpha/0.506
3vhaVHAHeat shock protein HSP 90-alpha/0.504
1osfKOSHeat shock protein HSP 90-alpha/0.503
4egkRDCHeat shock protein HSP 90-alpha/0.502
2werRDCATP-dependent molecular chaperone HSP82/0.500
4jqlVJ6Heat shock protein HSP 90-alpha/0.495
1uyePU9Heat shock protein HSP 90-alpha/0.494
2wi2ZZ3Heat shock protein HSP 90-alpha/0.491
4awp99AHeat shock protein HSP 90-alpha/0.487
3r4oFU3Heat shock protein HSP 90-alpha/0.486
2qg0A94Heat shock protein HSP 90-alpha/0.484
4xcjADPHeat shock cognate 90 kDa protein/0.484
2xhtC0YHeat shock protein HSP 90-alpha/0.483
1yc14BCHeat shock protein HSP 90-alpha/0.481
2xjjL81Heat shock protein HSP 90-alpha/0.480
4bqg50QHeat shock protein HSP 90-alpha/0.479
4xclAGSHeat shock cognate 90 kDa protein/0.478
2yeiXQIHeat shock protein HSP 90-alpha/0.471
3q5lKX2Heat shock protein 83-1/0.469
2bz5AB4Heat shock protein HSP 90-alpha/0.467
2xabVHDHeat shock protein HSP 90-alpha/0.465
3ekrPY9Heat shock protein HSP 90-alpha/0.460
2byi2DDHeat shock protein HSP 90-alpha/0.459
3d0bSNXHeat shock protein HSP 90-alpha/0.458
3omuIBDHeat shock protein 83/0.458
3qdd94MHeat shock protein HSP 90-alpha/0.457
4bqjXKLHeat shock protein HSP 90-alpha/0.457
4as94QSATP-dependent molecular chaperone HSP82/0.456
3ft8MOJHeat shock protein HSP 90-alpha/0.455
3opdHIEHeat shock protein 83/0.455
3k99PFTHeat shock protein HSP 90-alpha/0.449
1uy7PU4Heat shock protein HSP 90-alpha/0.447
1uymPU3Heat shock protein HSP 90-beta/0.447
3k981RCHeat shock protein HSP 90-alpha/0.447
4ivgANPTNF receptor-associated protein 1/0.445
3ekoPYUHeat shock protein HSP 90-alpha/0.444
2xcmADPCytosolic heat shock protein 90/0.443
2yee2ECHeat shock protein HSP 90-alpha/0.443
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2wi6ZZ6Heat shock protein HSP 90-alpha/0.441