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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2uzoC62Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2uzoC62Cyclin-dependent kinase 22.7.11.221.000
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.653
2c6o4SPCyclin-dependent kinase 22.7.11.220.648
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.609
4fkt48KCyclin-dependent kinase 22.7.11.220.599
1ke7LS3Cyclin-dependent kinase 22.7.11.220.596
1ke5LS1Cyclin-dependent kinase 22.7.11.220.594
2xmyCDKCyclin-dependent kinase 22.7.11.220.589
3r8lZ30Cyclin-dependent kinase 22.7.11.220.580
2btrU73Cyclin-dependent kinase 22.7.11.220.578
4ek610KCyclin-dependent kinase 22.7.11.220.578
2btsU32Cyclin-dependent kinase 22.7.11.220.574
2a0cCK9Cyclin-dependent kinase 22.7.11.220.573
3r1yX76Cyclin-dependent kinase 22.7.11.220.573
1ke9LS5Cyclin-dependent kinase 22.7.11.220.572
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.563
3sw418KCyclin-dependent kinase 22.7.11.220.558
4fki09KCyclin-dependent kinase 22.7.11.220.558
2r3lSCWCyclin-dependent kinase 22.7.11.220.555
3rm719ZCyclin-dependent kinase 22.7.11.220.555
3lfnA27Cyclin-dependent kinase 22.7.11.220.554
3rpv26ZCyclin-dependent kinase 22.7.11.220.554
4fkpLS5Cyclin-dependent kinase 22.7.11.220.554
1g5sI17Cyclin-dependent kinase 22.7.11.220.552
3lfqA28Cyclin-dependent kinase 22.7.11.220.550
4ek816KCyclin-dependent kinase 22.7.11.220.550
3rni21ZCyclin-dependent kinase 22.7.11.220.549
1pxmCK5Cyclin-dependent kinase 22.7.11.220.548
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.548
4fkq42KCyclin-dependent kinase 22.7.11.220.548
3qzgX67Cyclin-dependent kinase 22.7.11.220.547
3s2pPMUCyclin-dependent kinase 22.7.11.220.546
4fkj11KCyclin-dependent kinase 22.7.11.220.546
3rk708ZCyclin-dependent kinase 22.7.11.220.545
3rpo24ZCyclin-dependent kinase 22.7.11.220.545
1oirHDYCyclin-dependent kinase 22.7.11.220.543
4fkg4CKCyclin-dependent kinase 22.7.11.220.543
3sw719KCyclin-dependent kinase 22.7.11.220.542
4acm7YGCyclin-dependent kinase 22.7.11.220.542
3qu0X40Cyclin-dependent kinase 22.7.11.220.541
3qqhX0ACyclin-dependent kinase 22.7.11.220.540
2uznC96Cyclin-dependent kinase 22.7.11.220.539
1oitHDTCyclin-dependent kinase 22.7.11.220.538
4bgh3I6Cyclin-dependent kinase 22.7.11.220.538
2w06FRVCyclin-dependent kinase 22.7.11.220.537
3qxoX65Cyclin-dependent kinase 22.7.11.220.537
1ckpPVBCyclin-dependent kinase 22.7.11.220.536
1ke6LS2Cyclin-dependent kinase 22.7.11.220.536
1ykr628Cyclin-dependent kinase 22.7.11.220.536
2b52D42Cyclin-dependent kinase 22.7.11.220.535
4ez30S0Cyclin-dependent kinase 22.7.11.220.535
1pxlCK4Cyclin-dependent kinase 22.7.11.220.534
2vthLZ2Cyclin-dependent kinase 22.7.11.220.534
3rk507ZCyclin-dependent kinase 22.7.11.220.534
2exmZIPCyclin-dependent kinase 22.7.11.220.533
1y91CT9Cyclin-dependent kinase 22.7.11.220.532
1w8cN69Cyclin-dependent kinase 22.7.11.220.531
4fks46KCyclin-dependent kinase 22.7.11.220.531
3r7yZ04Cyclin-dependent kinase 22.7.11.220.529
3qwjX6ACyclin-dependent kinase 22.7.11.220.528
1w0xOLOCyclin-dependent kinase 22.7.11.220.527
3qtxX43Cyclin-dependent kinase 22.7.11.220.526
3qzhX69Cyclin-dependent kinase 22.7.11.220.526
3r1sX73Cyclin-dependent kinase 22.7.11.220.526
1b38ATPCyclin-dependent kinase 22.7.11.220.524
1di8DTQCyclin-dependent kinase 22.7.11.220.524
2r3iSCFCyclin-dependent kinase 22.7.11.220.524
2w1hL0FCyclin-dependent kinase 22.7.11.220.524
1ke8LS4Cyclin-dependent kinase 22.7.11.220.523
1p2a5BNCyclin-dependent kinase 22.7.11.220.523
2vtrLZBCyclin-dependent kinase 22.7.11.220.523
3s1h56ZCyclin-dependent kinase 22.7.11.220.523
3r73X87Cyclin-dependent kinase 22.7.11.220.522
3rm618ZCyclin-dependent kinase 22.7.11.220.521
2a4lRRCCyclin-dependent kinase 22.7.11.220.520
2r3jSCJCyclin-dependent kinase 22.7.11.220.519
3iggEFQCyclin-dependent kinase 22.7.11.220.518
3r7vZ02Cyclin-dependent kinase 22.7.11.220.518
3r83Z14Cyclin-dependent kinase 22.7.11.220.518
4fko20KCyclin-dependent kinase 22.7.11.220.518
3r7uX96Cyclin-dependent kinase 22.7.11.220.517
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.516
3qtzX42Cyclin-dependent kinase 22.7.11.220.516
4fkr45KCyclin-dependent kinase 22.7.11.220.516
3rk909ZCyclin-dependent kinase 22.7.11.220.515
1hckATPCyclin-dependent kinase 22.7.11.220.514
1pxoCK7Cyclin-dependent kinase 22.7.11.220.514
3fz1B98Cyclin-dependent kinase 22.7.11.220.514
1gih1PUCyclin-dependent kinase 22.7.11.220.513
2c6kDT2Cyclin-dependent kinase 22.7.11.220.513
2r3p3SCCyclin-dependent kinase 22.7.11.220.513
3qqkX02Cyclin-dependent kinase 22.7.11.220.513
3sqq99ZCyclin-dependent kinase 22.7.11.220.512
3rak03ZCyclin-dependent kinase 22.7.11.220.510
4erwSTUCyclin-dependent kinase 22.7.11.220.510
3rjc06ZCyclin-dependent kinase 22.7.11.220.509
3ezvEZVCyclin-dependent kinase 22.7.11.220.508
1pxpCK8Cyclin-dependent kinase 22.7.11.220.506
2r3kSCQCyclin-dependent kinase 22.7.11.220.506
4fkv61KCyclin-dependent kinase 22.7.11.220.506
2c6mDT5Cyclin-dependent kinase 22.7.11.220.505
3qtuX44Cyclin-dependent kinase 22.7.11.220.505
3pxyJWSCyclin-dependent kinase 22.7.11.220.504
1v1k3FPCyclin-dependent kinase 22.7.11.220.503
2c6lDT4Cyclin-dependent kinase 22.7.11.220.503
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.503
2vtsLZCCyclin-dependent kinase 22.7.11.220.503
4lyn1YGCyclin-dependent kinase 22.7.11.220.503
2b53D23Cyclin-dependent kinase 22.7.11.220.502
3r9dX6BCyclin-dependent kinase 22.7.11.220.502
2c6iDT1Cyclin-dependent kinase 22.7.11.220.500
3ddpRC8Cyclin-dependent kinase 22.7.11.220.499
3r8vZ62Cyclin-dependent kinase 22.7.11.220.498
3qqfX07Cyclin-dependent kinase 22.7.11.220.497
3pj8404Cyclin-dependent kinase 22.7.11.220.496
3rmf20ZCyclin-dependent kinase 22.7.11.220.496
3rpy27ZCyclin-dependent kinase 22.7.11.220.496
3unk0BYCyclin-dependent kinase 22.7.11.220.496
1b39ATPCyclin-dependent kinase 22.7.11.220.495
1y8yCT7Cyclin-dependent kinase 22.7.11.220.493
2duv371Cyclin-dependent kinase 22.7.11.220.493
2r3mSCXCyclin-dependent kinase 22.7.11.220.493
3qxpX64Cyclin-dependent kinase 22.7.11.220.493
3raiX85Cyclin-dependent kinase 22.7.11.220.493
1pyePM1Cyclin-dependent kinase 22.7.11.220.492
3roy22ZCyclin-dependent kinase 22.7.11.220.492
1h0w207Cyclin-dependent kinase 22.7.11.220.491
1h1s4SPCyclin-dependent kinase 22.7.11.220.491
3rkb12ZCyclin-dependent kinase 22.7.11.220.491
3lfsA07Cyclin-dependent kinase 22.7.11.220.488
3wblPDYCyclin-dependent kinase 22.7.11.220.488
1gii1PUCyclin-dependent kinase 22.7.11.220.487
1r78FMDCyclin-dependent kinase 22.7.11.220.487
1e1xNW1Cyclin-dependent kinase 22.7.11.220.486
3r1qX75Cyclin-dependent kinase 22.7.11.220.486
3r28XA0Cyclin-dependent kinase 22.7.11.220.486
3r7iX9ICyclin-dependent kinase 22.7.11.220.484
1aq1STUCyclin-dependent kinase 22.7.11.220.483
3r7eX88Cyclin-dependent kinase 22.7.11.220.483
4fklCK2Cyclin-dependent kinase 22.7.11.220.483
1vyzN5BCyclin-dependent kinase 22.7.11.220.482
3qx2X63Cyclin-dependent kinase 22.7.11.220.482
3r6xX84Cyclin-dependent kinase 22.7.11.220.482
2j9mPY8Cyclin-dependent kinase 22.7.11.220.481
3r71X86Cyclin-dependent kinase 22.7.11.220.481
2r3r6SCCyclin-dependent kinase 22.7.11.220.479
3py0SU9Cyclin-dependent kinase 22.7.11.220.479
3r9hZ67Cyclin-dependent kinase 22.7.11.220.479
3ral04ZCyclin-dependent kinase 22.7.11.220.479
1fvt106Cyclin-dependent kinase 22.7.11.220.476
3qruX19Cyclin-dependent kinase 22.7.11.220.476
3qqlX03Cyclin-dependent kinase 22.7.11.220.475
2w17I19Cyclin-dependent kinase 22.7.11.220.474
3rahO1ZCyclin-dependent kinase 22.7.11.220.474
3sheI85MAP kinase-activated protein kinase 32.7.11.10.474
2iw84SPCyclin-dependent kinase 22.7.11.220.473
2vttLZDCyclin-dependent kinase 22.7.11.220.472
3r8pZ46Cyclin-dependent kinase 22.7.11.220.472
3ig7EFPCyclin-dependent kinase 22.7.11.220.471
3unj0BXCyclin-dependent kinase 22.7.11.220.470
2b55D31Cyclin-dependent kinase 22.7.11.220.468
3ql8X01Cyclin-dependent kinase 22.7.11.220.468
4fkw62KCyclin-dependent kinase 22.7.11.220.467
1h1r6CPCyclin-dependent kinase 22.7.11.220.466
2iw94SPCyclin-dependent kinase 22.7.11.220.465
2r3fSC8Cyclin-dependent kinase 22.7.11.220.465
2uzeC95Cyclin-dependent kinase 22.7.11.220.465
3nynSGVG protein-coupled receptor kinase 62.7.11.160.465
3ti1B49Cyclin-dependent kinase 22.7.11.220.464
4eok4SPCyclin-dependent kinase 22.7.11.220.463
1h0vUN4Cyclin-dependent kinase 22.7.11.220.462
1oiyN41Cyclin-dependent kinase 22.7.11.220.462
1vyw292Cyclin-dependent kinase 22.7.11.220.462
3qwkX62Cyclin-dependent kinase 22.7.11.220.462
3s0o50ZCyclin-dependent kinase 22.7.11.220.462
4eor4SPCyclin-dependent kinase 22.7.11.220.462
1pxkCK3Cyclin-dependent kinase 22.7.11.220.461
2fvdLIACyclin-dependent kinase 22.7.11.220.461
4nj32KDCyclin-dependent kinase 22.7.11.220.461
5aniES4Cyclin-dependent kinase 22.7.11.220.461
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.460
3ddqRRCCyclin-dependent kinase 22.7.11.220.460
3qziX72Cyclin-dependent kinase 22.7.11.220.460
2bhhRYUCyclin-dependent kinase 22.7.11.220.459
2r64740Cyclin-dependent kinase 22.7.11.220.459
3ezrEZRCyclin-dependent kinase 22.7.11.220.459
4kd11QKCyclin-dependent kinase 22.7.11.220.459
2r3gSC9Cyclin-dependent kinase 22.7.11.220.458
2r3o2SCCyclin-dependent kinase 22.7.11.220.458
2vv9IM9Cyclin-dependent kinase 22.7.11.220.458
3r9nZ68Cyclin-dependent kinase 22.7.11.220.458
2b54D05Cyclin-dependent kinase 22.7.11.220.457
3ggfGVDSerine/threonine-protein kinase 26/0.457
3qtrX36Cyclin-dependent kinase 22.7.11.220.457
3dogNNNCyclin-dependent kinase 22.7.11.220.456
4eon1ROCyclin-dependent kinase 22.7.11.220.456
4jboWPHAurora kinase A2.7.11.10.456
1dm2HMDCyclin-dependent kinase 22.7.11.220.455
1oi9N20Cyclin-dependent kinase 22.7.11.220.452
2c5yMTWCyclin-dependent kinase 22.7.11.220.451
2r3q5SCCyclin-dependent kinase 22.7.11.220.450
4fx360KCyclin-dependent kinase 22.7.11.220.450
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.449
2c6tDT5Cyclin-dependent kinase 22.7.11.220.448
3uli1N3Cyclin-dependent kinase 22.7.11.220.448
4bcmT7ZCyclin-dependent kinase 22.7.11.220.448
2vtqLZACyclin-dependent kinase 22.7.11.220.447
3qrtX14Cyclin-dependent kinase 22.7.11.220.447
4bgg844Activin receptor type-12.7.11.300.447
1oiuN76Cyclin-dependent kinase 22.7.11.220.446
1xjdSTUProtein kinase C theta type2.7.11.130.446
2ds11CDCyclin-dependent kinase 22.7.11.220.446
2wpa889Cyclin-dependent kinase 22.7.11.220.445
2xnbY8LCyclin-dependent kinase 22.7.11.220.445
3r8zZ63Cyclin-dependent kinase 22.7.11.220.444
1oguST8Cyclin-dependent kinase 22.7.11.220.443
2x1nX1NCyclin-dependent kinase 22.7.11.220.443
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3r8uZ31Cyclin-dependent kinase 22.7.11.220.442
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.442
4aua4AUCyclin-dependent kinase 62.7.11.220.442
3qx4X4BCyclin-dependent kinase 22.7.11.220.441
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.441
4i22IREEpidermal growth factor receptor2.7.10.10.441
2uzbC75Cyclin-dependent kinase 22.7.11.220.440
2wotZZGTGF-beta receptor type-12.7.11.300.440