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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2uzdC85Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2uzdC85Cyclin-dependent kinase 22.7.11.221.000
2uzbC75Cyclin-dependent kinase 22.7.11.220.593
1fvv107Cyclin-dependent kinase 22.7.11.220.592
2vv9IM9Cyclin-dependent kinase 22.7.11.220.543
2w05FRTCyclin-dependent kinase 22.7.11.220.543
2w17I19Cyclin-dependent kinase 22.7.11.220.543
4eooATPCyclin-dependent kinase 22.7.11.220.543
4bcmT7ZCyclin-dependent kinase 22.7.11.220.540
3my5RFZCyclin-dependent kinase 22.7.11.220.532
1finATPCyclin-dependent kinase 22.7.11.220.525
3rak03ZCyclin-dependent kinase 22.7.11.220.519
4erwSTUCyclin-dependent kinase 22.7.11.220.518
2wihP48Cyclin-dependent kinase 22.7.11.220.516
4ez50RSCyclin-dependent kinase 62.7.11.220.514
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.512
1gih1PUCyclin-dependent kinase 22.7.11.220.510
3bhtMFRCyclin-dependent kinase 22.7.11.220.510
1g5sI17Cyclin-dependent kinase 22.7.11.220.509
1pkdUCNCyclin-dependent kinase 22.7.11.220.507
2cchATPCyclin-dependent kinase 22.7.11.220.507
1y91CT9Cyclin-dependent kinase 22.7.11.220.505
3nux3NVCyclin-dependent kinase 62.7.11.220.505
3qxpX64Cyclin-dependent kinase 22.7.11.220.505
4fkv61KCyclin-dependent kinase 22.7.11.220.504
4ii5ADPCyclin-dependent kinase 22.7.11.220.503
3s1h56ZCyclin-dependent kinase 22.7.11.220.499
3tnwF18Cyclin-dependent kinase 22.7.11.220.497
1p2a5BNCyclin-dependent kinase 22.7.11.220.496
2x1nX1NCyclin-dependent kinase 22.7.11.220.496
1pyePM1Cyclin-dependent kinase 22.7.11.220.495
1oguST8Cyclin-dependent kinase 22.7.11.220.494
2cjmATPCyclin-dependent kinase 22.7.11.220.494
3lltANPProtein serine/threonine kinase-1/0.493
3rni21ZCyclin-dependent kinase 22.7.11.220.493
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.491
4f081RSTyrosine-protein kinase JAK2/0.491
1qmzATPCyclin-dependent kinase 22.7.11.220.490
2vttLZDCyclin-dependent kinase 22.7.11.220.490
2c6tDT5Cyclin-dependent kinase 22.7.11.220.487
2eufLQQCyclin-dependent kinase 62.7.11.220.486
2iw94SPCyclin-dependent kinase 22.7.11.220.486
3rkb12ZCyclin-dependent kinase 22.7.11.220.486
4fkw62KCyclin-dependent kinase 22.7.11.220.486
1ykr628Cyclin-dependent kinase 22.7.11.220.485
2b52D42Cyclin-dependent kinase 22.7.11.220.485
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.485
5ap7SVEDual specificity protein kinase TTK2.7.12.10.485
1h1s4SPCyclin-dependent kinase 22.7.11.220.484
2uznC96Cyclin-dependent kinase 22.7.11.220.484
3uli1N3Cyclin-dependent kinase 22.7.11.220.484
1h1r6CPCyclin-dependent kinase 22.7.11.220.483
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.483
3ezvEZVCyclin-dependent kinase 22.7.11.220.482
3lfqA28Cyclin-dependent kinase 22.7.11.220.482
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.482
2r3lSCWCyclin-dependent kinase 22.7.11.220.480
3i60E86Mitogen-activated protein kinase 12.7.11.240.480
4b99R4LMitogen-activated protein kinase 72.7.11.240.480
4fx360KCyclin-dependent kinase 22.7.11.220.480
4i5cC5ITyrosine-protein kinase JAK1/0.480
2btsU32Cyclin-dependent kinase 22.7.11.220.478
4anmWULCasein kinase II subunit alpha2.7.11.10.478
4hvi19STyrosine-protein kinase JAK32.7.10.20.478
4j95ACPFibroblast growth factor receptor 2/0.477
1vyw292Cyclin-dependent kinase 22.7.11.220.476
2bhhRYUCyclin-dependent kinase 22.7.11.220.476
2c5nCK8Cyclin-dependent kinase 22.7.11.220.476
2iw84SPCyclin-dependent kinase 22.7.11.220.476
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.476
2cciATPCyclin-dependent kinase 22.7.11.220.475
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.475
4eomATPCyclin-dependent kinase 22.7.11.220.475
3lfnA27Cyclin-dependent kinase 22.7.11.220.474
3rk708ZCyclin-dependent kinase 22.7.11.220.474
3sqq99ZCyclin-dependent kinase 22.7.11.220.474
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.474
4fv6E57Mitogen-activated protein kinase 12.7.11.240.474
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.473
1aq1STUCyclin-dependent kinase 22.7.11.220.472
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.472
4btjATPTau-tubulin kinase 12.7.11.10.472
4e5w0NTTyrosine-protein kinase JAK1/0.472
1gii1PUCyclin-dependent kinase 22.7.11.220.471
1jstATPCyclin-dependent kinase 22.7.11.220.471
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.471
4jia1K3Tyrosine-protein kinase JAK2/0.471
1v1k3FPCyclin-dependent kinase 22.7.11.220.470
2uzlC94Cyclin-dependent kinase 22.7.11.220.470
2vu3LZECyclin-dependent kinase 22.7.11.220.470
4nj32KDCyclin-dependent kinase 22.7.11.220.470
2i40BLZCyclin-dependent kinase 22.7.11.220.469
3qtxX43Cyclin-dependent kinase 22.7.11.220.469
4dgmAGICasein kinase II subunit alpha2.7.11.10.469
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.469
1om1IQACasein kinase II subunit alpha2.7.11.10.468
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
3be9P04Casein kinase II subunit alpha2.7.11.10.468
3rmf20ZCyclin-dependent kinase 22.7.11.220.467
3wblPDYCyclin-dependent kinase 22.7.11.220.467
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.467
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.467
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.465
1oitHDTCyclin-dependent kinase 22.7.11.220.464
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.464
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.464
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.464
1dm2HMDCyclin-dependent kinase 22.7.11.220.463
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.463
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.463
3ddpRC8Cyclin-dependent kinase 22.7.11.220.463
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.463
1ke5LS1Cyclin-dependent kinase 22.7.11.220.462
1m2pHNACasein kinase II subunit alpha2.7.11.10.462
1w0xOLOCyclin-dependent kinase 22.7.11.220.462
2j9mPY8Cyclin-dependent kinase 22.7.11.220.462
4aqc88ATyrosine-protein kinase JAK2/0.462
4fk60UJTyrosine-protein kinase JAK1/0.462
1e9hINRCyclin-dependent kinase 22.7.11.220.461
1pxmCK5Cyclin-dependent kinase 22.7.11.220.461
2bkzSBCCyclin-dependent kinase 22.7.11.220.461
2vtsLZCCyclin-dependent kinase 22.7.11.220.461
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.461
4jqeANPCasein kinase II subunit alpha2.7.11.10.461
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.460
2pvlP55Casein kinase II subunit alpha2.7.11.10.460
2r3jSCJCyclin-dependent kinase 22.7.11.220.460
2vthLZ2Cyclin-dependent kinase 22.7.11.220.460
2xmyCDKCyclin-dependent kinase 22.7.11.220.460
3rk507ZCyclin-dependent kinase 22.7.11.220.460
2uzeC95Cyclin-dependent kinase 22.7.11.220.459
2zjwREFCasein kinase II subunit alpha2.7.11.10.459
3r9hZ67Cyclin-dependent kinase 22.7.11.220.459
1ke6LS2Cyclin-dependent kinase 22.7.11.220.458
2c6lDT4Cyclin-dependent kinase 22.7.11.220.458
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.458
2pvnP63Casein kinase II subunit alpha2.7.11.10.458
3lq5SLQCyclin-dependent kinase 92.7.11.220.458
3rk909ZCyclin-dependent kinase 22.7.11.220.458
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.458
5av2KMPDeath-associated protein kinase 12.7.11.10.458
2b55D31Cyclin-dependent kinase 22.7.11.220.457
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.457
3fz1B98Cyclin-dependent kinase 22.7.11.220.457
3nynSGVG protein-coupled receptor kinase 62.7.11.160.457
3qqkX02Cyclin-dependent kinase 22.7.11.220.457
4bgh3I6Cyclin-dependent kinase 22.7.11.220.457
3qwkX62Cyclin-dependent kinase 22.7.11.220.456
3r9oZ71Cyclin-dependent kinase 22.7.11.220.456
4eor4SPCyclin-dependent kinase 22.7.11.220.456
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.455
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.455
2pvhP19Casein kinase II subunit alpha2.7.11.10.455
2vtqLZACyclin-dependent kinase 22.7.11.220.455
3le62BZCyclin-dependent kinase 22.7.11.220.455
3ncz3NCRho-associated protein kinase 12.7.11.10.455
3rpv26ZCyclin-dependent kinase 22.7.11.220.455
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.455
4i3zADPCyclin-dependent kinase 22.7.11.220.455
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.454
4bchT7ZCyclin-dependent kinase 92.7.11.220.454
4eok4SPCyclin-dependent kinase 22.7.11.220.454
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.454
2bheBRYCyclin-dependent kinase 22.7.11.220.453
3at4CCKCasein kinase II subunit alpha2.7.11.10.453
3pxkPXKFocal adhesion kinase 12.7.10.20.453
3r1yX76Cyclin-dependent kinase 22.7.11.220.453
4ek610KCyclin-dependent kinase 22.7.11.220.453
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.453
1pxoCK7Cyclin-dependent kinase 22.7.11.220.452
4grb0XGCasein kinase II subunit alpha2.7.11.10.452
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.452
1oirHDYCyclin-dependent kinase 22.7.11.220.451
3qtrX36Cyclin-dependent kinase 22.7.11.220.451
3qtzX42Cyclin-dependent kinase 22.7.11.220.451
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.451
4e4n0NLTyrosine-protein kinase JAK1/0.450
1oi9N20Cyclin-dependent kinase 22.7.11.220.449
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.449
2wxvWXVCyclin-dependent kinase 22.7.11.220.449
3ddqRRCCyclin-dependent kinase 22.7.11.220.449
4btjADPTau-tubulin kinase 12.7.11.10.449
4dgnLU2Casein kinase II subunit alpha2.7.11.10.449
4ix6ADPUncharacterized protein/0.449
1ke9LS5Cyclin-dependent kinase 22.7.11.220.448
1oiuN76Cyclin-dependent kinase 22.7.11.220.448
2ijmADPFocal adhesion kinase 12.7.10.20.448
2j0lANPFocal adhesion kinase 12.7.10.20.448
3a7jADPSerine/threonine-protein kinase 242.7.11.10.448
3qxoX65Cyclin-dependent kinase 22.7.11.220.448
3r73X87Cyclin-dependent kinase 22.7.11.220.448
4fkt48KCyclin-dependent kinase 22.7.11.220.448
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.448
4l9i8PRRhodopsin kinase/0.448
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.447
3bqr4RBDeath-associated protein kinase 3/0.447
3hmm855TGF-beta receptor type-12.7.11.300.447
3r7uX96Cyclin-dependent kinase 22.7.11.220.447
3r83Z14Cyclin-dependent kinase 22.7.11.220.447
3sheI85MAP kinase-activated protein kinase 32.7.11.10.447
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.447
1di8DTQCyclin-dependent kinase 22.7.11.220.446
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.446
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.446
3c4xATPRhodopsin kinase/0.446
3qtqX35Cyclin-dependent kinase 22.7.11.220.446
4bcpT3CCyclin-dependent kinase 22.7.11.220.446
4ehzJAKTyrosine-protein kinase JAK1/0.446
3ezrEZRCyclin-dependent kinase 22.7.11.220.445
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.445
3q9xEMOCasein kinase II subunit alpha2.7.11.10.445
1pxpCK8Cyclin-dependent kinase 22.7.11.220.444
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.444
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.444
2xnbY8LCyclin-dependent kinase 22.7.11.220.444
3rm719ZCyclin-dependent kinase 22.7.11.220.444
3roy22ZCyclin-dependent kinase 22.7.11.220.444
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.444
2uzoC62Cyclin-dependent kinase 22.7.11.220.443
2wpa889Cyclin-dependent kinase 22.7.11.220.443
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.443
3qtuX44Cyclin-dependent kinase 22.7.11.220.443
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.443
4fkg4CKCyclin-dependent kinase 22.7.11.220.443
4ic7ANPMitogen-activated protein kinase 72.7.11.240.443
5dosATPAurora kinase A2.7.11.10.443
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.442
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.442
3r9dX6BCyclin-dependent kinase 22.7.11.220.442
3ral04ZCyclin-dependent kinase 22.7.11.220.442
3s2pPMUCyclin-dependent kinase 22.7.11.220.442
4hvh19RTyrosine-protein kinase JAK32.7.10.20.442
4qmpDKISerine/threonine-protein kinase 242.7.11.10.442
1oiyN41Cyclin-dependent kinase 22.7.11.220.441
1pxlCK4Cyclin-dependent kinase 22.7.11.220.441
1r78FMDCyclin-dependent kinase 22.7.11.220.441
4btkDTQTau-tubulin kinase 12.7.11.10.441
5e8ySTUTGF-beta receptor type-22.7.11.300.441
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.440
3gu7ADPDeath-associated protein kinase 12.7.11.10.440
4acm7YGCyclin-dependent kinase 22.7.11.220.440
4bcnT9NCyclin-dependent kinase 22.7.11.220.440
4g170VNCasein kinase I isoform gamma-32.7.11.10.440