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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2tpsTPSThiamine-phosphate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2tpsTPSThiamine-phosphate synthase/1.000
1g4sTPSThiamine-phosphate synthase/0.584
1g4tFTPThiamine-phosphate synthase/0.584
1g69TZPThiamine-phosphate synthase/0.553
1g67TZPThiamine-phosphate synthase/0.536
1g6cTZPThiamine-phosphate synthase/0.508
3nl6TPSUncharacterized protein/0.469
1g6cIFPThiamine-phosphate synthase/0.468
3o153NMThiamine-phosphate synthase/0.444