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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.11.000
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.572
4k33ACPFibroblast growth factor receptor 32.7.10.10.569
3ttjJBIMitogen-activated protein kinase 102.7.11.240.539
5awmANPStress-activated protein kinase JNK2.7.11.240.537
3oriAGSSerine/threonine protein kinase/0.536
5drdATPAurora kinase A2.7.11.10.533
5dt3ATPAurora kinase A2.7.11.10.532
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.530
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.529
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.527
5e92ANPTGF-beta receptor type-22.7.11.300.523
2h96893Mitogen-activated protein kinase 82.7.11.240.520
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.520
4jboWPHAurora kinase A2.7.11.10.519
3clyACPFibroblast growth factor receptor 2/0.517
1pmv537Mitogen-activated protein kinase 102.7.11.240.516
1ol5ADPAurora kinase A2.7.11.10.515
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.515
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.515
3ormAGSSerine/threonine protein kinase/0.515
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.514
4ic7ANPMitogen-activated protein kinase 72.7.11.240.513
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.513
1ir3ANPInsulin receptor2.7.10.10.511
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.510
4lfiGNPCasein kinase II subunit alpha2.7.11.10.510
1ol7ADPAurora kinase A2.7.11.10.509
5dnrATPAurora kinase A2.7.11.10.508
2henADPEphrin type-B receptor 22.7.10.10.505
3l8p0CEAngiopoietin-1 receptor2.7.10.10.505
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.505
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.505
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.504
3c50ADPRhodopsin kinase/0.503
3gubGUBDeath-associated protein kinase 12.7.11.10.503
2p33J07Mitogen-activated protein kinase 102.7.11.240.502
3gxlQIGTGF-beta receptor type-12.7.11.300.502
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.501
3eljGS7Mitogen-activated protein kinase 82.7.11.240.501
5dn3ATPAurora kinase A2.7.11.10.501
1rw8580TGF-beta receptor type-12.7.11.300.500
3c4wATPRhodopsin kinase/0.500
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.499
4hvh19RTyrosine-protein kinase JAK32.7.10.20.499
3a7jADPSerine/threonine-protein kinase 242.7.11.10.497
3hmm855TGF-beta receptor type-12.7.11.300.497
3oroAGSSerine/threonine protein kinase/0.496
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.496
2py3ACPFibroblast growth factor receptor 2/0.495
2qoqANPEphrin type-A receptor 32.7.10.10.495
2zdt46CMitogen-activated protein kinase 102.7.11.240.495
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.495
1dawANPCasein kinase II subunit alpha2.7.11.10.494
4jr7GNPCasein kinase II subunit alpha2.7.11.10.494
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.493
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.493
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.493
5dt4ATPAurora kinase A2.7.11.10.493
4utdACPAurora kinase A2.7.11.10.492
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.491
2c6tDT5Cyclin-dependent kinase 22.7.11.220.491
2o0uC0MMitogen-activated protein kinase 102.7.11.240.489
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.489
4gmy0X5Tyrosine-protein kinase JAK2/0.489
4qnyANPMitogen activated protein kinase, putative/0.489
1py5PY1TGF-beta receptor type-12.7.11.300.488
2xneASHAurora kinase A2.7.11.10.488
5e8ySTUTGF-beta receptor type-22.7.11.300.488
2qo9ANPEphrin type-A receptor 32.7.10.10.487
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.487
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.487
5e8xSTUTGF-beta receptor type-12.7.11.300.487
1aq1STUCyclin-dependent kinase 22.7.11.220.486
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.486
4e4m0NHTyrosine-protein kinase JAK2/0.486
4qmlANPSerine/threonine-protein kinase 242.7.11.10.486
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.485
2hog710Serine/threonine-protein kinase Chk12.7.11.10.485
3kvxFMYMitogen-activated protein kinase 102.7.11.240.485
3qc9ADPRhodopsin kinase/0.485
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.484
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.484
2izrBRKCasein kinase I isoform gamma-32.7.11.10.484
2pmlANPUncharacterized protein/0.484
1ol6ATPAurora kinase A2.7.11.10.483
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.483
4i22IREEpidermal growth factor receptor2.7.10.10.483
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.483
3i60E86Mitogen-activated protein kinase 12.7.11.240.482
3r9hZ67Cyclin-dependent kinase 22.7.11.220.482
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.482
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.482
2wihP48Cyclin-dependent kinase 22.7.11.220.481
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.480
2pz5ACPFibroblast growth factor receptor 2/0.480
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.480
3w33W19Epidermal growth factor receptor2.7.10.10.480
4btjADPTau-tubulin kinase 12.7.11.10.480
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.480
4ux9ANPMitogen-activated protein kinase 82.7.11.240.480
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.479
1di8DTQCyclin-dependent kinase 22.7.11.220.478
2acxANPG protein-coupled receptor kinase 62.7.11.160.478
2b1pAIZMitogen-activated protein kinase 102.7.11.240.478
2pvnP63Casein kinase II subunit alpha2.7.11.10.478
2x1nX1NCyclin-dependent kinase 22.7.11.220.478
2xrwANPMitogen-activated protein kinase 82.7.11.240.478
4bgg844Activin receptor type-12.7.11.300.478
4g170VNCasein kinase I isoform gamma-32.7.11.10.478
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.478
2dwbANPAurora kinase A2.7.11.10.477
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.477
3a60STURibosomal protein S6 kinase beta-12.7.11.10.477
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.477
4j97ACPFibroblast growth factor receptor 2/0.477
4xlvACPInsulin receptor2.7.10.10.477
5e8wSTUTGF-beta receptor type-12.7.11.300.477
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.476
2o2u738Mitogen-activated protein kinase 102.7.11.240.476
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.476
3w18N13Aurora kinase A2.7.11.10.476
1h1r6CPCyclin-dependent kinase 22.7.11.220.475
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.475
2w4kADPDeath-associated protein kinase 12.7.11.10.475
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
1csnATPCasein kinase I homolog 12.7.11.10.474
1lp4ANPCasein kinase II subunit alpha2.7.11.10.474
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.474
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.474
4gu94GUFocal adhesion kinase 12.7.10.20.474
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.473
1dayGNPCasein kinase II subunit alpha2.7.11.10.473
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.473
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.473
4oauADP2-5A-dependent ribonuclease3.1.260.473
1u4dDBQActivated CDC42 kinase 1/0.472
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.472
2wotZZGTGF-beta receptor type-12.7.11.300.472
2xs0ANPMitogen-activated protein kinase 82.7.11.240.472
3eej53RUncharacterized protein/0.472
4gk3L87Ephrin type-A receptor 32.7.10.10.472
4yuqKS1Calmodulin-like domain protein kinase/0.472
3gu6ADPDeath-associated protein kinase 12.7.11.10.471
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.471
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.471
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.471
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.470
2iw94SPCyclin-dependent kinase 22.7.11.220.470
2pvhP19Casein kinase II subunit alpha2.7.11.10.470
3gu5ANPDeath-associated protein kinase 12.7.11.10.470
3gu83GUDeath-associated protein kinase 12.7.11.10.470
3zptM8YGag-Pol polyprotein3.4.23.160.470
4dgnLU2Casein kinase II subunit alpha2.7.11.10.470
4jbpYPHAurora kinase A2.7.11.10.470
1mq4ADPAurora kinase A2.7.11.10.469
1u54ACPActivated CDC42 kinase 1/0.469
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.469
2bheBRYCyclin-dependent kinase 22.7.11.220.469
2excJNKMitogen-activated protein kinase 102.7.11.240.469
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.469
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.469
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.469
4jqeANPCasein kinase II subunit alpha2.7.11.10.469
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.469
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.469
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.469
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.468
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.468
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.468
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.468
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.468
1vjy460TGF-beta receptor type-12.7.11.300.467
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.467
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.467
3hllI45Mitogen-activated protein kinase 14/0.467
3rkb12ZCyclin-dependent kinase 22.7.11.220.467
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.467
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.467
4zohFADPutative oxidoreductase FAD-binding subunit/0.467
1i44ACPInsulin receptor2.7.10.10.466
2itzIREEpidermal growth factor receptor2.7.10.10.466
2pzpACPFibroblast growth factor receptor 2/0.466
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.466
3cgfJNFMitogen-activated protein kinase 102.7.11.240.466
3dogNNNCyclin-dependent kinase 22.7.11.220.466
3k5uPFQAurora kinase A2.7.11.10.466
4riyADPEpidermal growth factor receptor2.7.10.10.466
4wkqIREEpidermal growth factor receptor2.7.10.10.466
1oiyN41Cyclin-dependent kinase 22.7.11.220.465
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.465
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.465
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.465
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.465
4anmWULCasein kinase II subunit alpha2.7.11.10.465
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.465
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.465
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.464
3gc9B45Mitogen-activated protein kinase 112.7.11.240.464
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.464
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.464
4gk2L66Ephrin type-A receptor 32.7.10.10.464
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.464
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.464
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.463
1qmfKEFPenicillin-binding protein 2x/0.463
2pvyACPFibroblast growth factor receptor 2/0.463
3vs3VSETyrosine-protein kinase HCK2.7.10.20.463
4aotGW8Serine/threonine-protein kinase 102.7.11.10.463
4dgmAGICasein kinase II subunit alpha2.7.11.10.463
4y93746Tyrosine-protein kinase/0.463
2uzbC75Cyclin-dependent kinase 22.7.11.220.462
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.462
3vryB43Tyrosine-protein kinase HCK2.7.10.20.462
4loqSB4Mitogen-activated protein kinase 14/0.462
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.461
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.461
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.461
2v7a627Tyrosine-protein kinase ABL12.7.10.20.461
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.461
3le62BZCyclin-dependent kinase 22.7.11.220.461
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.461
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.461
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.461
4oavACP2-5A-dependent ribonuclease3.1.260.461
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.460
2c6eHPMAurora kinase A2.7.11.10.460
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.460
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.460
4cegADPAurora kinase A2.7.11.10.460
2qo7ANPEphrin type-A receptor 32.7.10.10.459
2xikJ60Serine/threonine-protein kinase 252.7.11.10.459
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
4b99R4LMitogen-activated protein kinase 72.7.11.240.459
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.459
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.459
4tuvCPZCytochrome P450 1191.140.459
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.459
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.458
3ggfGVDSerine/threonine-protein kinase 26/0.458
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.458
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.458
4qmzB49Serine/threonine-protein kinase 242.7.11.10.458
2wqeADPAurora kinase A2.7.11.10.457
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.457
3flsFLSMitogen-activated protein kinase 14/0.457
3hwrNDP2-dehydropantoate 2-reductase/0.457
4cd0AWJALK tyrosine kinase receptor2.7.10.10.457
4fkw62KCyclin-dependent kinase 22.7.11.220.457
4fv7E94Mitogen-activated protein kinase 12.7.11.240.457
4lrjANPUncharacterized protein/0.457
4s32ANPMitogen-activated protein kinase 12.7.11.240.457
3orkAGSSerine/threonine protein kinase/0.456
3v9y24LPeroxisome proliferator-activated receptor gamma/0.456
1ke6LS2Cyclin-dependent kinase 22.7.11.220.455
2xuuADPDeath-associated protein kinase 12.7.11.10.455
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.455
4dgo0JWCasein kinase II subunit alpha2.7.11.10.455
5dr9SKEAurora kinase A2.7.11.10.455
1cm8ANPMitogen-activated protein kinase 12/0.454
1gih1PUCyclin-dependent kinase 22.7.11.220.454
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.454
3lfqA28Cyclin-dependent kinase 22.7.11.220.454
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.454
4eooATPCyclin-dependent kinase 22.7.11.220.454
4eos1ROCyclin-dependent kinase 22.7.11.220.454
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.454
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.454
4nka2K7Fibroblast growth factor receptor 1/0.454
4zseANPEpidermal growth factor receptor2.7.10.10.454
5auwQUEDeath-associated protein kinase 12.7.11.10.454
5dr2ATPAurora kinase A2.7.11.10.454
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.453
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.453
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.453
3vthAPCCarbamoyltransferase/0.453
4fob0USALK tyrosine kinase receptor2.7.10.10.453
4pl3ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.453
4qmpDKISerine/threonine-protein kinase 242.7.11.10.453
5cvhADPCasein kinase II subunit alpha2.7.11.10.453
1ke9LS5Cyclin-dependent kinase 22.7.11.220.452
2cchATPCyclin-dependent kinase 22.7.11.220.452
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.452
2vhzNAIAlanine dehydrogenase1.4.1.10.452
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.452
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.452
4bn1ADPAurora kinase A2.7.11.10.452
4du82P0Mevalonate diphosphate decarboxylase/0.452
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.452
1p4fDRGDeath-associated protein kinase 12.7.11.10.451
2gs7ANPEpidermal growth factor receptor2.7.10.10.451
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.451
3s79ASDAromatase1.14.14.140.451
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.451
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.451
4hge15VTyrosine-protein kinase JAK2/0.451
4jbqVX6Aurora kinase A2.7.11.10.451
1dkfBMSRetinoic acid receptor alpha/0.450
1hosPHPGag-Pol polyprotein/0.450
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.450
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.450
3mvl38PMitogen-activated protein kinase 14/0.450
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.450
3wowANPCasein kinase II subunit alpha2.7.11.10.450
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.450
4o0uADNAurora kinase A2.7.11.10.450
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.450
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.450
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.449
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.449
1qmzATPCyclin-dependent kinase 22.7.11.220.449
2ds11CDCyclin-dependent kinase 22.7.11.220.449
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.449
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.449
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.449
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.449
3poz03PEpidermal growth factor receptor2.7.10.10.449
3r9dX6BCyclin-dependent kinase 22.7.11.220.449
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.449
4hvg19QTyrosine-protein kinase JAK32.7.10.20.449
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1m2pHNACasein kinase II subunit alpha2.7.11.10.448
1yvj4STTyrosine-protein kinase JAK32.7.10.20.448
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.448
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.448
2xpuTDCTetracycline repressor protein class D/0.448
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.448
3nizADPCdc2-like CDK2/CDC28 like protein kinase/0.448
3wecAUICytochrome P450/0.448
4fkg4CKCyclin-dependent kinase 22.7.11.220.448
4l4cCAMCamphor 5-monooxygenase1.14.15.10.448
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1jpaANPEphrin type-B receptor 22.7.10.10.447
1oguST8Cyclin-dependent kinase 22.7.11.220.447
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2itnANPEpidermal growth factor receptor2.7.10.10.447
2nniMTKCytochrome P450 2C8/0.447
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2znq401Peroxisome proliferator-activated receptor delta/0.447
3el51UNGag-Pol polyprotein/0.447
3gobHXXDdmC/0.447
3r9uFADThioredoxin reductase/0.447
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.447
4eor4SPCyclin-dependent kinase 22.7.11.220.447
4lv7ADPInositol-pentakisphosphate 2-kinase2.7.1.1580.447
4mwhATPCasein kinase II subunit alpha2.7.11.10.447
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.447
4qgiROCGag-Pol polyprotein3.4.23.160.447
5hwsNAP2-dehydropantoate 2-reductase/0.447
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.446
2eufLQQCyclin-dependent kinase 62.7.11.220.446
2w06FRVCyclin-dependent kinase 22.7.11.220.446
2y4gTIRTamL/0.446
2y6o1N1Ephrin type-A receptor 42.7.10.10.446
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.446
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.446
4lopSB4Mitogen-activated protein kinase 14/0.446
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
4y8wSTRSteroid 21-hydroxylase/0.446
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.446
5auxKMPDeath-associated protein kinase 12.7.11.10.446
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.445
1ppjANYCytochrome b/0.445
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.445
3bvb017Gag-Pol polyprotein3.4.23.160.445
4c62XWWTyrosine-protein kinase JAK2/0.445
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.445
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.445
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.445
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.445
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.445
2np8CC3Aurora kinase A2.7.11.10.444
2uznC96Cyclin-dependent kinase 22.7.11.220.444
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.444
3dt1P40Mitogen-activated protein kinase 14/0.444
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.444
3nbwTR4Ketohexokinase/0.444
3te4ACODopamine N-acetyltransferase/0.444
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4c4jX21Dual specificity protein kinase TTK2.7.12.10.444
4eomATPCyclin-dependent kinase 22.7.11.220.444
4fv9E71Mitogen-activated protein kinase 12.7.11.240.444
4jrnANPRhoptry kinase family protein/0.444
1a5uATPPyruvate kinase PKM2.7.1.400.443
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.443
2btsU32Cyclin-dependent kinase 22.7.11.220.443
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.443
2p4yC03Peroxisome proliferator-activated receptor gamma/0.443
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.443
3bu5ATPInsulin receptor2.7.10.10.443
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.443
3mddFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.443
3rk507ZCyclin-dependent kinase 22.7.11.220.443
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4l4dCAMCamphor 5-monooxygenase1.14.15.10.443
4lv8ADPRhoptry protein 5 C/0.443
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1fwkADPHomoserine kinase2.7.1.390.442
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.442
2gjlFMNNitronate monooxygenase1.13.12.160.442
2gjnFMNNitronate monooxygenase1.13.12.160.442
2y9qANPMitogen-activated protein kinase 12.7.11.240.442
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.442
3bhtMFRCyclin-dependent kinase 22.7.11.220.442
3eek53SUncharacterized protein/0.442
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.442
3ortAGSSerine/threonine protein kinase/0.442
3umw596Serine/threonine-protein kinase pim-12.7.11.10.442
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.442
4erwSTUCyclin-dependent kinase 22.7.11.220.442
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.442
4g2fC07Ephrin type-A receptor 32.7.10.10.442
4gt3ATPMitogen-activated protein kinase 12.7.11.240.442
4n9iPCGCatabolite expression activator/0.442
1dirNADDihydropteridine reductase1.5.1.340.441
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1om1IQACasein kinase II subunit alpha2.7.11.10.441
1zys199Serine/threonine-protein kinase Chk12.7.11.10.441
2gejGDDPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.441
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.441
3pvwQRXBeta-adrenergic receptor kinase 12.7.11.150.441
3upf0BUPolyprotein/0.441
3vetADPnebramycin 5' synthase6.1.2.20.441
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.441
4g1wG1WMitogen-activated protein kinase 82.7.11.240.441
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.441
4kba1QMCasein kinase I isoform delta2.7.11.10.441
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
6cp4CAMCamphor 5-monooxygenase1.14.15.10.441
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.440
2yfxVGHALK tyrosine kinase receptor2.7.10.10.440
3at4CCKCasein kinase II subunit alpha2.7.11.10.440
3ddpRC8Cyclin-dependent kinase 22.7.11.220.440
3efwAK8Aurora kinase A2.7.11.10.440
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.440
3r71X86Cyclin-dependent kinase 22.7.11.220.440
3sa9A68Protease/0.440
3u9eCOALmo1369 protein/0.440
3uli1N3Cyclin-dependent kinase 22.7.11.220.440
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4fod0UVALK tyrosine kinase receptor2.7.10.10.440
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.440
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.440
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.440
4iirANPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.440
4jnqFDAThioredoxin reductase/0.440
4nr42LKCREB-binding protein/0.440
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.440
5a3cNADSIR2 family protein/0.440
5cvcPLPSerine racemase/0.440