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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2rggGNPGTPase HRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2rggGNPGTPase HRas/1.000
4xvqGNPGTPase HRas/0.679
3tgpGNPGTPase HRas/0.610
4hdqGNPRas-related protein Rap-1b/0.599
4xvrGNPGTPase HRas/0.594
1uadGNPRas-related protein Ral-A/0.583
4lpkGDPGTPase KRas/0.544
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.539
3k9lGNPGTPase HRas/0.539
4l8gGDPGTPase KRas/0.530
3kkqGDPRas-related protein M-Ras/0.525
4lucGDPGTPase KRas/0.524
4l9sGDPGTPase HRas/0.520
2fe4GDPRas-related protein Rab-6B/0.519
4lv6GDPGTPase KRas/0.517
3kkoGNPRas-related protein M-Ras/0.516
2ce2GDPGTPase HRas/0.513
1lfdGNPGTPase HRas/0.510
4tq9GDPGTPase KRas/0.510
4epwGDPGTPase KRas/0.509
1n6lGTPRas-related protein Rab-5A/0.506
4g0nGNPGTPase HRas/0.505
4o2rGDPGTP-binding protein Rheb/0.505
4q03GDPGTPase KRas/0.502
3ddcGNPGTPase HRas/0.498
4wa7GDPGTPase KRas/0.497
3pitGNPRas-related protein M-Ras/0.495
4q02GDPGTPase KRas/0.493
2rgeGNPGTPase HRas/0.489
4obeGDPGTPase KRas/0.484
4ldjGDPGTPase KRas/0.483
3lbhGNPGTPase HRas/0.482
4dsnGCPGTPase KRas/0.479
4epxGDPGTPase KRas/0.479
3cphGDPRas-related protein SEC4/0.478
4lrwGDPGTPase KRas/0.477
4ql3GDPGTPase KRas/0.477
1xtsGTPGTP-binding protein Rheb/0.474
4nyjGNPGTPase HRas/0.474
1x1rGDPRas-related protein M-Ras/0.473
3i3sGNPGTPase HRas/0.472
1oixGDPRas-related protein Rab-11A/0.466
1z2aGDPRas-related protein Rab-23/0.465
2c5lGTPGTPase HRas/0.465
2fg5GNPRas-related protein Rab-31/0.464
3k8yGNPGTPase HRas/0.464
1yu9GNPRas-related protein Rab-4A/0.463
3pcrGTPADP-ribosylation factor 6/0.462
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.461
3mjhGTPRas-related protein Rab-5A/0.461
3oivGNPGTPase HRas/0.461
2q3fGNPRas-related GTP-binding protein D/0.458
3vhxGTPADP-ribosylation factor 6/0.457
3lbiGNPGTPase HRas/0.455
3oesGNPGTPase RhebL1/0.455
2bmeGNPRas-related protein Rab-4A/0.452
4dltGNPGTPase HRas/0.452
2rgbGNPGTPase HRas/0.451
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.449
3oiwGNPGTPase HRas/0.449
2rgcGNPGTPase HRas/0.446
3l8yGNPGTPase HRas/0.446
4uj3GNPRas-related protein Rab-11A/0.446
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.445
4cidANPEH domain-containing protein 2/0.445
5b2zGNPGTPase HRas/0.443
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.441