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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2rgeGNPGTPase HRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2rgeGNPGTPase HRas/1.000
2rgcGNPGTPase HRas/0.758
3oivGNPGTPase HRas/0.732
4dlxGNPGTPase HRas/0.676
3rs5GNPGTPase HRas/0.662
4dlzGNPGTPase HRas/0.661
3ddcGNPGTPase HRas/0.659
3rs0GNPGTPase HRas/0.642
3k8yGNPGTPase HRas/0.640
4dlvGNPGTPase HRas/0.640
3lbnGNPGTPase HRas/0.639
3kkoGNPRas-related protein M-Ras/0.627
2rgbGNPGTPase HRas/0.624
3v4fGNPGTPase HRas/0.615
4dlwGNPGTPase HRas/0.607
3oesGNPGTPase RhebL1/0.600
3i3sGNPGTPase HRas/0.588
3kucGDPRas-related protein Rap-1A/0.585
4hdqGNPRas-related protein Rap-1b/0.581
2c5lGTPGTPase HRas/0.579
3pitGNPRas-related protein M-Ras/0.579
1zc4GNPRas-related protein Ral-A/0.575
4dsnGCPGTPase KRas/0.570
3lbhGNPGTPase HRas/0.569
4dltGNPGTPase HRas/0.564
3x1zGNPRas-related protein Rap-1b/0.562
4nyiGNPGTPase HRas/0.562
4xvqGNPGTPase HRas/0.562
3rslGNPGTPase HRas/0.561
3oiwGNPGTPase HRas/0.560
1e96GTPRas-related C3 botulinum toxin substrate 1/0.559
3l8yGNPGTPase HRas/0.557
1xtsGTPGTP-binding protein Rheb/0.556
3rs7GNPGTPase HRas/0.555
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.554
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.551
1a2bGSPTransforming protein RhoA/0.548
4g0nGNPGTPase HRas/0.548
4nyjGNPGTPase HRas/0.544
1xtrGNPGTP-binding protein Rheb/0.543
1zc3GNPRas-related protein Ral-A/0.540
3a6pGTPGTP-binding nuclear protein Ran/0.538
2fe4GDPRas-related protein Rab-6B/0.537
3oiuGNPGTPase HRas/0.537
4mitGTPRho-related protein racC/0.528
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.527
3cphGDPRas-related protein SEC4/0.527
3e5hGNPRas-related protein Rab-28/0.527
4lhwGNPRas-related protein Rab-8A/0.526
5b2zGNPGTPase HRas/0.526
3rs4GNPGTPase HRas/0.525
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.523
2msdGNPMHC class I alpha chain/0.523
4hdoGNPRas-related protein Rap-1b/0.521
1m7bGTPRho-related GTP-binding protein RhoE/0.517
2ce2GDPGTPase HRas/0.517
4tq9GDPGTPase KRas/0.517
1t91GTPRas-related protein Rab-7a/0.516
3w3zGTPGTP-binding nuclear protein Ran/0.516
1yzqGNPRas-related protein Rab-6A/0.515
4rkfGNPRas-related protein Rab-3/0.515
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.512
4dlsGNPGTPase HRas/0.512
3tgpGNPGTPase HRas/0.511
4xvrGNPGTPase HRas/0.509
3lbiGNPGTPase HRas/0.508
4l9sGDPGTPase HRas/0.508
4l9wGNPGTPase HRas/0.506
3bbpGTPRas-related protein Rab-6A/0.505
1lfdGNPGTPase HRas/0.504
2rggGNPGTPase HRas/0.504
3nbzGTPGTP-binding nuclear protein Ran/0.502
1ibrGNPGTP-binding nuclear protein Ran/0.500
1oixGDPRas-related protein Rab-11A/0.500
1g17GNPRas-related protein SEC4/0.499
3tsoGNPRas-related protein Rab-25/0.499
4lpkGDPGTPase KRas/0.499
1zbdGTPRas-related protein Rab-3A/0.497
2gcpGSPRho-related GTP-binding protein RhoC/0.497
3rabGNPRas-related protein Rab-3A/0.496
1yhnGTPRas-related protein Rab-7a/0.495
5difGNPGTP-binding nuclear protein Ran/0.495
4wa7GDPGTPase KRas/0.494
4l8gGDPGTPase KRas/0.493
1gwnGTPRho-related GTP-binding protein RhoE/0.489
5jljGNPGTP-binding nuclear protein Ran/0.488
1cxzGSPTransforming protein RhoA/0.486
4js0GNPCell division control protein 42 homolog/0.486
1z2aGDPRas-related protein Rab-23/0.485
2bkuGTPGTP-binding nuclear protein Ran/0.485
2zetGTPRas-related protein Rab-27B/0.483
3ea5GDPGTP-binding nuclear protein Ran/0.483
4ol0GTPGTP-binding nuclear protein Ran/0.483
3a58GNPGTP-binding protein RHO1/0.482
4qxaGTPRas-related protein Rab-9A/0.482
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.481
4epwGDPGTPase KRas/0.481
3kz1GSPTransforming protein RhoA/0.480
4o2lGTPGTP-binding protein Rheb/0.480
3k9lGNPGTPase HRas/0.477
4dxaGSPRas-related protein Rap-1b/0.477
4lucGDPGTPase KRas/0.477
4obeGDPGTPase KRas/0.477
3kudGDPGTPase HRas/0.473
4o25GTPGTP-binding protein Rheb/0.473
2ffqGSPRas-related protein Rab-6B/0.470
3kkqGDPRas-related protein M-Ras/0.470
3mjhGTPRas-related protein Rab-5A/0.470
4kvgGTPRas-related protein Rap-1A/0.468
2mscGDPMHC class I alpha chain/0.465
3eg5GNPCell division control protein 42 homolog/0.465
5dhaGNPGTP-binding nuclear protein Ran/0.465
4q02GDPGTPase KRas/0.461
4lv6GDPGTPase KRas/0.460
3bc1GNPRas-related protein Rab-27A/0.459
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.458
3wyfGTPGTP-binding nuclear protein/0.456
4dsoGSPGTPase KRas/0.455
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.454
1vg8GNPRas-related protein Rab-7a/0.453
4ql3GDPGTPase KRas/0.453
1yu9GNPRas-related protein Rab-4A/0.452
1x1rGDPRas-related protein M-Ras/0.451
2cl6CAGGTPase HRas/0.449
4cidANPEH domain-containing protein 2/0.449
5hpyGDPTransforming protein RhoA/0.449
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.443
4obuPLPPyridoxal-dependent decarboxylase domain protein/0.441
1n6lGTPRas-related protein Rab-5A/0.440
4o2rGDPGTP-binding protein Rheb/0.440