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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2r3lSCWCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2r3lSCWCyclin-dependent kinase 22.7.11.221.000
4acm7YGCyclin-dependent kinase 22.7.11.220.682
2uznC96Cyclin-dependent kinase 22.7.11.220.660
4fkj11KCyclin-dependent kinase 22.7.11.220.652
2r3kSCQCyclin-dependent kinase 22.7.11.220.651
4fks46KCyclin-dependent kinase 22.7.11.220.649
4fkt48KCyclin-dependent kinase 22.7.11.220.638
3s1h56ZCyclin-dependent kinase 22.7.11.220.636
3rak03ZCyclin-dependent kinase 22.7.11.220.634
2r3jSCJCyclin-dependent kinase 22.7.11.220.632
2vthLZ2Cyclin-dependent kinase 22.7.11.220.622
3sw418KCyclin-dependent kinase 22.7.11.220.622
1gih1PUCyclin-dependent kinase 22.7.11.220.620
3rjc06ZCyclin-dependent kinase 22.7.11.220.618
3ezvEZVCyclin-dependent kinase 22.7.11.220.616
2w06FRVCyclin-dependent kinase 22.7.11.220.614
3rpv26ZCyclin-dependent kinase 22.7.11.220.611
2btrU73Cyclin-dependent kinase 22.7.11.220.610
3rni21ZCyclin-dependent kinase 22.7.11.220.609
1fvt106Cyclin-dependent kinase 22.7.11.220.607
2r3p3SCCyclin-dependent kinase 22.7.11.220.604
1pxmCK5Cyclin-dependent kinase 22.7.11.220.603
2c6iDT1Cyclin-dependent kinase 22.7.11.220.603
3fz1B98Cyclin-dependent kinase 22.7.11.220.603
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.602
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.601
4bgh3I6Cyclin-dependent kinase 22.7.11.220.601
3lfnA27Cyclin-dependent kinase 22.7.11.220.600
1y91CT9Cyclin-dependent kinase 22.7.11.220.597
4fki09KCyclin-dependent kinase 22.7.11.220.597
2c6o4SPCyclin-dependent kinase 22.7.11.220.596
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.596
3ral04ZCyclin-dependent kinase 22.7.11.220.596
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.595
4fkq42KCyclin-dependent kinase 22.7.11.220.594
3lfqA28Cyclin-dependent kinase 22.7.11.220.593
2uzoC62Cyclin-dependent kinase 22.7.11.220.592
1v1k3FPCyclin-dependent kinase 22.7.11.220.591
2r3mSCXCyclin-dependent kinase 22.7.11.220.591
1oitHDTCyclin-dependent kinase 22.7.11.220.590
1w0xOLOCyclin-dependent kinase 22.7.11.220.589
1ke5LS1Cyclin-dependent kinase 22.7.11.220.588
1ke7LS3Cyclin-dependent kinase 22.7.11.220.588
2xmyCDKCyclin-dependent kinase 22.7.11.220.588
3qtxX43Cyclin-dependent kinase 22.7.11.220.587
2b52D42Cyclin-dependent kinase 22.7.11.220.585
4fkv61KCyclin-dependent kinase 22.7.11.220.585
2w1hL0FCyclin-dependent kinase 22.7.11.220.583
3s2pPMUCyclin-dependent kinase 22.7.11.220.583
1ke6LS2Cyclin-dependent kinase 22.7.11.220.582
4fkpLS5Cyclin-dependent kinase 22.7.11.220.581
1gii1PUCyclin-dependent kinase 22.7.11.220.580
3r9dX6BCyclin-dependent kinase 22.7.11.220.580
4ek816KCyclin-dependent kinase 22.7.11.220.580
4fkg4CKCyclin-dependent kinase 22.7.11.220.580
3r7uX96Cyclin-dependent kinase 22.7.11.220.579
2r3iSCFCyclin-dependent kinase 22.7.11.220.577
3qzgX67Cyclin-dependent kinase 22.7.11.220.577
3r8lZ30Cyclin-dependent kinase 22.7.11.220.576
4ek610KCyclin-dependent kinase 22.7.11.220.575
1vyzN5BCyclin-dependent kinase 22.7.11.220.574
1p2a5BNCyclin-dependent kinase 22.7.11.220.573
3qxoX65Cyclin-dependent kinase 22.7.11.220.573
1pxoCK7Cyclin-dependent kinase 22.7.11.220.572
2w17I19Cyclin-dependent kinase 22.7.11.220.572
4fkr45KCyclin-dependent kinase 22.7.11.220.571
1pxkCK3Cyclin-dependent kinase 22.7.11.220.570
3iggEFQCyclin-dependent kinase 22.7.11.220.570
3rk507ZCyclin-dependent kinase 22.7.11.220.569
3rk909ZCyclin-dependent kinase 22.7.11.220.569
3pj8404Cyclin-dependent kinase 22.7.11.220.568
3qtzX42Cyclin-dependent kinase 22.7.11.220.567
1urwI1PCyclin-dependent kinase 22.7.11.220.563
2a0cCK9Cyclin-dependent kinase 22.7.11.220.562
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.562
4fkw62KCyclin-dependent kinase 22.7.11.220.562
1ke9LS5Cyclin-dependent kinase 22.7.11.220.561
3rmf20ZCyclin-dependent kinase 22.7.11.220.561
3sw719KCyclin-dependent kinase 22.7.11.220.561
3rk708ZCyclin-dependent kinase 22.7.11.220.560
2duv371Cyclin-dependent kinase 22.7.11.220.559
2r64740Cyclin-dependent kinase 22.7.11.220.558
1oguST8Cyclin-dependent kinase 22.7.11.220.557
1pyePM1Cyclin-dependent kinase 22.7.11.220.557
3qzhX69Cyclin-dependent kinase 22.7.11.220.557
1ykr628Cyclin-dependent kinase 22.7.11.220.556
3rm719ZCyclin-dependent kinase 22.7.11.220.556
4ez30S0Cyclin-dependent kinase 22.7.11.220.556
1g5sI17Cyclin-dependent kinase 22.7.11.220.555
2btsU32Cyclin-dependent kinase 22.7.11.220.555
3qtuX44Cyclin-dependent kinase 22.7.11.220.553
1ke8LS4Cyclin-dependent kinase 22.7.11.220.552
1pxlCK4Cyclin-dependent kinase 22.7.11.220.552
3qqhX0ACyclin-dependent kinase 22.7.11.220.551
3r7iX9ICyclin-dependent kinase 22.7.11.220.551
4fko20KCyclin-dependent kinase 22.7.11.220.551
1pxpCK8Cyclin-dependent kinase 22.7.11.220.550
3wblPDYCyclin-dependent kinase 22.7.11.220.550
2b53D23Cyclin-dependent kinase 22.7.11.220.549
3ti1B49Cyclin-dependent kinase 22.7.11.220.548
3qu0X40Cyclin-dependent kinase 22.7.11.220.547
3rpy27ZCyclin-dependent kinase 22.7.11.220.547
2a4lRRCCyclin-dependent kinase 22.7.11.220.546
3pxyJWSCyclin-dependent kinase 22.7.11.220.546
3rm618ZCyclin-dependent kinase 22.7.11.220.546
3r1yX76Cyclin-dependent kinase 22.7.11.220.545
2vv9IM9Cyclin-dependent kinase 22.7.11.220.544
3ig7EFPCyclin-dependent kinase 22.7.11.220.544
4nj32KDCyclin-dependent kinase 22.7.11.220.543
3uli1N3Cyclin-dependent kinase 22.7.11.220.542
2vttLZDCyclin-dependent kinase 22.7.11.220.541
3qtrX36Cyclin-dependent kinase 22.7.11.220.541
1h1s4SPCyclin-dependent kinase 22.7.11.220.540
3sqq99ZCyclin-dependent kinase 22.7.11.220.540
1b39ATPCyclin-dependent kinase 22.7.11.220.537
2vtsLZCCyclin-dependent kinase 22.7.11.220.537
1dm2HMDCyclin-dependent kinase 22.7.11.220.534
1oirHDYCyclin-dependent kinase 22.7.11.220.534
3r9oZ71Cyclin-dependent kinase 22.7.11.220.533
1di8DTQCyclin-dependent kinase 22.7.11.220.532
2b55D31Cyclin-dependent kinase 22.7.11.220.532
2c6lDT4Cyclin-dependent kinase 22.7.11.220.532
3r7vZ02Cyclin-dependent kinase 22.7.11.220.532
3r8zZ63Cyclin-dependent kinase 22.7.11.220.532
3roy22ZCyclin-dependent kinase 22.7.11.220.532
1y8yCT7Cyclin-dependent kinase 22.7.11.220.531
3qqlX03Cyclin-dependent kinase 22.7.11.220.531
3unk0BYCyclin-dependent kinase 22.7.11.220.530
2j9mPY8Cyclin-dependent kinase 22.7.11.220.529
3qqkX02Cyclin-dependent kinase 22.7.11.220.529
1aq1STUCyclin-dependent kinase 22.7.11.220.528
3r73X87Cyclin-dependent kinase 22.7.11.220.528
3r6xX84Cyclin-dependent kinase 22.7.11.220.527
3rkb12ZCyclin-dependent kinase 22.7.11.220.527
3lfsA07Cyclin-dependent kinase 22.7.11.220.526
2c6kDT2Cyclin-dependent kinase 22.7.11.220.525
1ckpPVBCyclin-dependent kinase 22.7.11.220.524
1oiqHDUCyclin-dependent kinase 22.7.11.220.524
2r3gSC9Cyclin-dependent kinase 22.7.11.220.524
3r7yZ04Cyclin-dependent kinase 22.7.11.220.523
1fvv107Cyclin-dependent kinase 22.7.11.220.522
4fklCK2Cyclin-dependent kinase 22.7.11.220.522
1w8cN69Cyclin-dependent kinase 22.7.11.220.521
2iw84SPCyclin-dependent kinase 22.7.11.220.521
1gij2PUCyclin-dependent kinase 22.7.11.220.520
3r9hZ67Cyclin-dependent kinase 22.7.11.220.519
1h1r6CPCyclin-dependent kinase 22.7.11.220.518
3r83Z14Cyclin-dependent kinase 22.7.11.220.518
3rpo24ZCyclin-dependent kinase 22.7.11.220.518
3tnwF18Cyclin-dependent kinase 22.7.11.220.518
1finATPCyclin-dependent kinase 22.7.11.220.517
1vyw292Cyclin-dependent kinase 22.7.11.220.517
3py0SU9Cyclin-dependent kinase 22.7.11.220.517
4lyn1YGCyclin-dependent kinase 22.7.11.220.517
3ezrEZRCyclin-dependent kinase 22.7.11.220.516
3r1sX73Cyclin-dependent kinase 22.7.11.220.516
3raiX85Cyclin-dependent kinase 22.7.11.220.516
4eok4SPCyclin-dependent kinase 22.7.11.220.516
1h0w207Cyclin-dependent kinase 22.7.11.220.515
2c6tDT5Cyclin-dependent kinase 22.7.11.220.515
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.515
2iw94SPCyclin-dependent kinase 22.7.11.220.514
3r1qX75Cyclin-dependent kinase 22.7.11.220.514
1b38ATPCyclin-dependent kinase 22.7.11.220.513
3qqfX07Cyclin-dependent kinase 22.7.11.220.511
3rzb02ZCyclin-dependent kinase 22.7.11.220.511
2r3fSC8Cyclin-dependent kinase 22.7.11.220.510
2x1nX1NCyclin-dependent kinase 22.7.11.220.510
2r3q5SCCyclin-dependent kinase 22.7.11.220.509
3ddpRC8Cyclin-dependent kinase 22.7.11.220.509
2b54D05Cyclin-dependent kinase 22.7.11.220.508
4fx360KCyclin-dependent kinase 22.7.11.220.508
3qtqX35Cyclin-dependent kinase 22.7.11.220.507
2i40BLZCyclin-dependent kinase 22.7.11.220.506
3bhtMFRCyclin-dependent kinase 22.7.11.220.506
3r8uZ31Cyclin-dependent kinase 22.7.11.220.506
3sheI85MAP kinase-activated protein kinase 32.7.11.10.506
2uzdC85Cyclin-dependent kinase 22.7.11.220.505
1oi9N20Cyclin-dependent kinase 22.7.11.220.504
2bhhRYUCyclin-dependent kinase 22.7.11.220.504
3qwjX6ACyclin-dependent kinase 22.7.11.220.504
1oiyN41Cyclin-dependent kinase 22.7.11.220.502
1r78FMDCyclin-dependent kinase 22.7.11.220.502
3r28XA0Cyclin-dependent kinase 22.7.11.220.502
3qzfX66Cyclin-dependent kinase 22.7.11.220.501
2vtqLZACyclin-dependent kinase 22.7.11.220.500
1unlRRCCyclin-dependent-like kinase 52.7.11.10.499
2xnbY8LCyclin-dependent kinase 22.7.11.220.499
3unj0BXCyclin-dependent kinase 22.7.11.220.499
3qruX19Cyclin-dependent kinase 22.7.11.220.498
3s0o50ZCyclin-dependent kinase 22.7.11.220.498
4qmpDKISerine/threonine-protein kinase 242.7.11.10.498
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.496
3qwkX62Cyclin-dependent kinase 22.7.11.220.496
2c6mDT5Cyclin-dependent kinase 22.7.11.220.495
3ddqRRCCyclin-dependent kinase 22.7.11.220.495
3r8pZ46Cyclin-dependent kinase 22.7.11.220.495
1h0vUN4Cyclin-dependent kinase 22.7.11.220.494
4eomATPCyclin-dependent kinase 22.7.11.220.494
1pkdUCNCyclin-dependent kinase 22.7.11.220.492
4kd11QKCyclin-dependent kinase 22.7.11.220.491
1vjy460TGF-beta receptor type-12.7.11.300.490
2eufLQQCyclin-dependent kinase 62.7.11.220.489
2r3r6SCCyclin-dependent kinase 22.7.11.220.489
2wihP48Cyclin-dependent kinase 22.7.11.220.489
3qrtX14Cyclin-dependent kinase 22.7.11.220.489
3ggfGVDSerine/threonine-protein kinase 26/0.488
4bcpT3CCyclin-dependent kinase 22.7.11.220.488
1eh4IC1Casein kinase I homolog 12.7.11.10.487
3s00Z60Cyclin-dependent kinase 22.7.11.220.486
4eor4SPCyclin-dependent kinase 22.7.11.220.485
2exmZIPCyclin-dependent kinase 22.7.11.220.484
2pvlP55Casein kinase II subunit alpha2.7.11.10.484
2uzeC95Cyclin-dependent kinase 22.7.11.220.484
4eon1ROCyclin-dependent kinase 22.7.11.220.484
3r71X86Cyclin-dependent kinase 22.7.11.220.483
4aua4AUCyclin-dependent kinase 62.7.11.220.482
2vu3LZECyclin-dependent kinase 22.7.11.220.481
4bcmT7ZCyclin-dependent kinase 22.7.11.220.480
2wxvWXVCyclin-dependent kinase 22.7.11.220.479
3r7eX88Cyclin-dependent kinase 22.7.11.220.479
3qx2X63Cyclin-dependent kinase 22.7.11.220.478
4ii5ADPCyclin-dependent kinase 22.7.11.220.478
5aniES4Cyclin-dependent kinase 22.7.11.220.478
1oiuN76Cyclin-dependent kinase 22.7.11.220.477
2pvnP63Casein kinase II subunit alpha2.7.11.10.476
2c5yMTWCyclin-dependent kinase 22.7.11.220.475
2r3o2SCCyclin-dependent kinase 22.7.11.220.475
2cchATPCyclin-dependent kinase 22.7.11.220.474
3my5RFZCyclin-dependent kinase 22.7.11.220.474
2uzlC94Cyclin-dependent kinase 22.7.11.220.472
3dogNNNCyclin-dependent kinase 22.7.11.220.472
1hckATPCyclin-dependent kinase 22.7.11.220.471
3rahO1ZCyclin-dependent kinase 22.7.11.220.471
4bcoT6QCyclin-dependent kinase 22.7.11.220.471
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.471
3qqgX06Cyclin-dependent kinase 22.7.11.220.470
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.470
4ivb1J5Tyrosine-protein kinase JAK1/0.470
4eooATPCyclin-dependent kinase 22.7.11.220.469
2c5nCK8Cyclin-dependent kinase 22.7.11.220.468
4bcnT9NCyclin-dependent kinase 22.7.11.220.468
3tiz3TICyclin-dependent kinase 22.7.11.220.467
2uzbC75Cyclin-dependent kinase 22.7.11.220.464
4dgo0JWCasein kinase II subunit alpha2.7.11.10.464
2ds11CDCyclin-dependent kinase 22.7.11.220.463
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.463
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.463
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.463
2wpa889Cyclin-dependent kinase 22.7.11.220.462
1h1q2A6Cyclin-dependent kinase 22.7.11.220.461
3qtwX3ACyclin-dependent kinase 22.7.11.220.461
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.461
1e1xNW1Cyclin-dependent kinase 22.7.11.220.460
1e9hINRCyclin-dependent kinase 22.7.11.220.460
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.460
3gubGUBDeath-associated protein kinase 12.7.11.10.460
3gxlQIGTGF-beta receptor type-12.7.11.300.460
3be9P04Casein kinase II subunit alpha2.7.11.10.459
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.459
1xjdSTUProtein kinase C theta type2.7.11.130.458
5dr6SKEAurora kinase A2.7.11.10.458
3qx4X4BCyclin-dependent kinase 22.7.11.220.457
3ql8X01Cyclin-dependent kinase 22.7.11.220.456
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.456
1om1IQACasein kinase II subunit alpha2.7.11.10.455
1m2rMNYCasein kinase II subunit alpha2.7.11.10.454
3qziX72Cyclin-dependent kinase 22.7.11.220.453
2xikJ60Serine/threonine-protein kinase 252.7.11.10.452
4eos1ROCyclin-dependent kinase 22.7.11.220.452
4gub0Y4Casein kinase II subunit alpha2.7.11.10.451
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.450
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.450
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.449
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.449
3lltANPProtein serine/threonine kinase-1/0.449
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.449
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.449
4btjATPTau-tubulin kinase 12.7.11.10.449
2chlDKICasein kinase I isoform gamma-32.7.11.10.448
2f2cAP9Cyclin-dependent kinase 62.7.11.220.448
4aacAAVMitogen-activated protein kinase 14/0.448
4e5w0NTTyrosine-protein kinase JAK1/0.448
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
1h1pCMGCyclin-dependent kinase 22.7.11.220.447
2c69CT8Cyclin-dependent kinase 22.7.11.220.447
3hmm855TGF-beta receptor type-12.7.11.300.447
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.447
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3r9nZ68Cyclin-dependent kinase 22.7.11.220.447
4dgnLU2Casein kinase II subunit alpha2.7.11.10.447
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.447
2c4g514Cyclin-dependent kinase 22.7.11.220.446
2wotZZGTGF-beta receptor type-12.7.11.300.446
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.445
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.445
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.444
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.444
3nynSGVG protein-coupled receptor kinase 62.7.11.160.444
1m2pHNACasein kinase II subunit alpha2.7.11.10.443
1qmzATPCyclin-dependent kinase 22.7.11.220.443
4i3zADPCyclin-dependent kinase 22.7.11.220.443
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.443
5dr9SKEAurora kinase A2.7.11.10.443
2fumMIXSerine/threonine-protein kinase PknB2.7.11.10.442
4anmWULCasein kinase II subunit alpha2.7.11.10.442
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.442
4j54G52Gag-Pol polyprotein3.4.23.160.442
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.442
4qgiROCGag-Pol polyprotein3.4.23.160.441
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.440