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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2r3iSCFCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2r3iSCFCyclin-dependent kinase 22.7.11.221.000
4fkt48KCyclin-dependent kinase 22.7.11.220.696
2c6iDT1Cyclin-dependent kinase 22.7.11.220.693
2r3r6SCCyclin-dependent kinase 22.7.11.220.657
2r3p3SCCyclin-dependent kinase 22.7.11.220.634
2r3fSC8Cyclin-dependent kinase 22.7.11.220.632
2btrU73Cyclin-dependent kinase 22.7.11.220.620
2r3q5SCCyclin-dependent kinase 22.7.11.220.616
2r3o2SCCyclin-dependent kinase 22.7.11.220.604
4fklCK2Cyclin-dependent kinase 22.7.11.220.594
3r1yX76Cyclin-dependent kinase 22.7.11.220.590
4ek816KCyclin-dependent kinase 22.7.11.220.581
2r3mSCXCyclin-dependent kinase 22.7.11.220.565
4ek610KCyclin-dependent kinase 22.7.11.220.565
2r3gSC9Cyclin-dependent kinase 22.7.11.220.562
2r3jSCJCyclin-dependent kinase 22.7.11.220.559
4fkq42KCyclin-dependent kinase 22.7.11.220.559
1y8yCT7Cyclin-dependent kinase 22.7.11.220.557
2c6kDT2Cyclin-dependent kinase 22.7.11.220.553
1h0vUN4Cyclin-dependent kinase 22.7.11.220.550
3s2pPMUCyclin-dependent kinase 22.7.11.220.550
1w8cN69Cyclin-dependent kinase 22.7.11.220.549
1h0w207Cyclin-dependent kinase 22.7.11.220.548
1b39ATPCyclin-dependent kinase 22.7.11.220.547
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.546
1oitHDTCyclin-dependent kinase 22.7.11.220.545
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.537
3r8vZ62Cyclin-dependent kinase 22.7.11.220.535
3fz1B98Cyclin-dependent kinase 22.7.11.220.534
4fkpLS5Cyclin-dependent kinase 22.7.11.220.532
1ykr628Cyclin-dependent kinase 22.7.11.220.529
2c6lDT4Cyclin-dependent kinase 22.7.11.220.529
2j9mPY8Cyclin-dependent kinase 22.7.11.220.527
4fki09KCyclin-dependent kinase 22.7.11.220.527
3pxyJWSCyclin-dependent kinase 22.7.11.220.526
1ke5LS1Cyclin-dependent kinase 22.7.11.220.525
2a0cCK9Cyclin-dependent kinase 22.7.11.220.525
3sw719KCyclin-dependent kinase 22.7.11.220.524
4fkr45KCyclin-dependent kinase 22.7.11.220.524
4fks46KCyclin-dependent kinase 22.7.11.220.523
2r3lSCWCyclin-dependent kinase 22.7.11.220.522
3lfqA28Cyclin-dependent kinase 22.7.11.220.522
2exmZIPCyclin-dependent kinase 22.7.11.220.520
1pxmCK5Cyclin-dependent kinase 22.7.11.220.518
1w0xOLOCyclin-dependent kinase 22.7.11.220.517
3ezvEZVCyclin-dependent kinase 22.7.11.220.517
2c6o4SPCyclin-dependent kinase 22.7.11.220.516
2uzoC62Cyclin-dependent kinase 22.7.11.220.516
3r83Z14Cyclin-dependent kinase 22.7.11.220.515
3raiX85Cyclin-dependent kinase 22.7.11.220.515
3rm719ZCyclin-dependent kinase 22.7.11.220.515
2uznC96Cyclin-dependent kinase 22.7.11.220.514
3r8lZ30Cyclin-dependent kinase 22.7.11.220.514
2vtsLZCCyclin-dependent kinase 22.7.11.220.513
3r7vZ02Cyclin-dependent kinase 22.7.11.220.513
3r7yZ04Cyclin-dependent kinase 22.7.11.220.510
4fko20KCyclin-dependent kinase 22.7.11.220.509
2vthLZ2Cyclin-dependent kinase 22.7.11.220.508
1pxoCK7Cyclin-dependent kinase 22.7.11.220.507
4fkg4CKCyclin-dependent kinase 22.7.11.220.506
1pxjCK2Cyclin-dependent kinase 22.7.11.220.505
2vv9IM9Cyclin-dependent kinase 22.7.11.220.505
3sw418KCyclin-dependent kinase 22.7.11.220.504
1vyzN5BCyclin-dependent kinase 22.7.11.220.503
2r64740Cyclin-dependent kinase 22.7.11.220.503
3r73X87Cyclin-dependent kinase 22.7.11.220.503
4kd11QKCyclin-dependent kinase 22.7.11.220.502
1gih1PUCyclin-dependent kinase 22.7.11.220.501
2a4lRRCCyclin-dependent kinase 22.7.11.220.501
3rni21ZCyclin-dependent kinase 22.7.11.220.501
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.500
3qqhX0ACyclin-dependent kinase 22.7.11.220.499
3rahO1ZCyclin-dependent kinase 22.7.11.220.499
4ez30S0Cyclin-dependent kinase 22.7.11.220.498
1pxpCK8Cyclin-dependent kinase 22.7.11.220.497
2w17I19Cyclin-dependent kinase 22.7.11.220.495
3r7uX96Cyclin-dependent kinase 22.7.11.220.494
2btsU32Cyclin-dependent kinase 22.7.11.220.492
3sqq99ZCyclin-dependent kinase 22.7.11.220.492
1ke6LS2Cyclin-dependent kinase 22.7.11.220.491
1p2a5BNCyclin-dependent kinase 22.7.11.220.491
4bgh3I6Cyclin-dependent kinase 22.7.11.220.491
3qxoX65Cyclin-dependent kinase 22.7.11.220.489
4nj32KDCyclin-dependent kinase 22.7.11.220.489
1ke7LS3Cyclin-dependent kinase 22.7.11.220.488
3qzgX67Cyclin-dependent kinase 22.7.11.220.488
2c69CT8Cyclin-dependent kinase 22.7.11.220.486
3qtuX44Cyclin-dependent kinase 22.7.11.220.486
1oirHDYCyclin-dependent kinase 22.7.11.220.485
2c6mDT5Cyclin-dependent kinase 22.7.11.220.485
1b38ATPCyclin-dependent kinase 22.7.11.220.484
3lfnA27Cyclin-dependent kinase 22.7.11.220.484
3qzfX66Cyclin-dependent kinase 22.7.11.220.484
2b54D05Cyclin-dependent kinase 22.7.11.220.483
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.483
3qtxX43Cyclin-dependent kinase 22.7.11.220.483
3rpv26ZCyclin-dependent kinase 22.7.11.220.482
3qqfX07Cyclin-dependent kinase 22.7.11.220.481
3r1sX73Cyclin-dependent kinase 22.7.11.220.481
3le62BZCyclin-dependent kinase 22.7.11.220.479
3rak03ZCyclin-dependent kinase 22.7.11.220.479
3iggEFQCyclin-dependent kinase 22.7.11.220.478
3qtzX42Cyclin-dependent kinase 22.7.11.220.478
4acm7YGCyclin-dependent kinase 22.7.11.220.478
3r8uZ31Cyclin-dependent kinase 22.7.11.220.477
3s1h56ZCyclin-dependent kinase 22.7.11.220.477
1g5sI17Cyclin-dependent kinase 22.7.11.220.476
2b53D23Cyclin-dependent kinase 22.7.11.220.475
2xmyCDKCyclin-dependent kinase 22.7.11.220.474
3lfsA07Cyclin-dependent kinase 22.7.11.220.474
3r9nZ68Cyclin-dependent kinase 22.7.11.220.474
1urwI1PCyclin-dependent kinase 22.7.11.220.473
3qzhX69Cyclin-dependent kinase 22.7.11.220.473
3qqlX03Cyclin-dependent kinase 22.7.11.220.472
3pj8404Cyclin-dependent kinase 22.7.11.220.470
3roy22ZCyclin-dependent kinase 22.7.11.220.470
1e1xNW1Cyclin-dependent kinase 22.7.11.220.469
3r71X86Cyclin-dependent kinase 22.7.11.220.469
3rjc06ZCyclin-dependent kinase 22.7.11.220.469
3rmf20ZCyclin-dependent kinase 22.7.11.220.469
2fvdLIACyclin-dependent kinase 22.7.11.220.466
1pxkCK3Cyclin-dependent kinase 22.7.11.220.464
2b52D42Cyclin-dependent kinase 22.7.11.220.463
3unk0BYCyclin-dependent kinase 22.7.11.220.463
1ke9LS5Cyclin-dependent kinase 22.7.11.220.462
4fx360KCyclin-dependent kinase 22.7.11.220.462
1oguST8Cyclin-dependent kinase 22.7.11.220.461
3rk507ZCyclin-dependent kinase 22.7.11.220.461
3qtsX46Cyclin-dependent kinase 22.7.11.220.460
3qwjX6ACyclin-dependent kinase 22.7.11.220.460
1gii1PUCyclin-dependent kinase 22.7.11.220.459
1h1s4SPCyclin-dependent kinase 22.7.11.220.459
1oiqHDUCyclin-dependent kinase 22.7.11.220.459
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.459
3rm618ZCyclin-dependent kinase 22.7.11.220.459
1vyw292Cyclin-dependent kinase 22.7.11.220.458
2bhhRYUCyclin-dependent kinase 22.7.11.220.458
1pxlCK4Cyclin-dependent kinase 22.7.11.220.457
2vttLZDCyclin-dependent kinase 22.7.11.220.457
3r9oZ71Cyclin-dependent kinase 22.7.11.220.457
1pyePM1Cyclin-dependent kinase 22.7.11.220.456
2w06FRVCyclin-dependent kinase 22.7.11.220.456
3qx2X63Cyclin-dependent kinase 22.7.11.220.456
3r9hZ67Cyclin-dependent kinase 22.7.11.220.456
4eomATPCyclin-dependent kinase 22.7.11.220.456
4fkw62KCyclin-dependent kinase 22.7.11.220.456
1gz8MBPCyclin-dependent kinase 22.7.11.220.455
2r3kSCQCyclin-dependent kinase 22.7.11.220.455
3s00Z60Cyclin-dependent kinase 22.7.11.220.455
3nynSGVG protein-coupled receptor kinase 62.7.11.160.454
3qu0X40Cyclin-dependent kinase 22.7.11.220.454
2xnbY8LCyclin-dependent kinase 22.7.11.220.453
3rk708ZCyclin-dependent kinase 22.7.11.220.453
4fkv61KCyclin-dependent kinase 22.7.11.220.453
3r9dX6BCyclin-dependent kinase 22.7.11.220.452
3rpy27ZCyclin-dependent kinase 22.7.11.220.451
3ti1B49Cyclin-dependent kinase 22.7.11.220.451
3r28XA0Cyclin-dependent kinase 22.7.11.220.450
5aniES4Cyclin-dependent kinase 22.7.11.220.450
1di8DTQCyclin-dependent kinase 22.7.11.220.449
1dm2HMDCyclin-dependent kinase 22.7.11.220.449
3i60E86Mitogen-activated protein kinase 12.7.11.240.449
3unj0BXCyclin-dependent kinase 22.7.11.220.449
1fvt106Cyclin-dependent kinase 22.7.11.220.447
3r7eX88Cyclin-dependent kinase 22.7.11.220.447
2c6tDT5Cyclin-dependent kinase 22.7.11.220.446
2x1nX1NCyclin-dependent kinase 22.7.11.220.446
4k8aK8AFocal adhesion kinase 12.7.10.20.446
1oiyN41Cyclin-dependent kinase 22.7.11.220.445
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.445
2wxvWXVCyclin-dependent kinase 22.7.11.220.445
1fvv107Cyclin-dependent kinase 22.7.11.220.444
2w1hL0FCyclin-dependent kinase 22.7.11.220.444
1ckpPVBCyclin-dependent kinase 22.7.11.220.443
3r7iX9ICyclin-dependent kinase 22.7.11.220.443
3rk909ZCyclin-dependent kinase 22.7.11.220.442
1aq1STUCyclin-dependent kinase 22.7.11.220.441
2iw84SPCyclin-dependent kinase 22.7.11.220.441
2wihP48Cyclin-dependent kinase 22.7.11.220.440
4erwSTUCyclin-dependent kinase 22.7.11.220.440